Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Getting genetic ancestry right for science and society

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Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk

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Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

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Identification of type 2 diabetes loci in 433,540 East Asian individuals

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Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

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Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

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Genomics of disease risk in globally diverse populations

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Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

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Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

(2018) David Z. Pan et al.   Nature Communications

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

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DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes

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Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel

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Genetic regulatory signatures underlying islet gene expression and type 2 diabetes

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Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

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A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

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Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

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Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

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Bayesian refinement of association signals for 14 loci in 3 common diseases

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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

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Type 2 Diabetes Risk Alleles Demonstrate Extreme Directional Differentiation among Human Populations, Compared to Other Diseases

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

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