A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

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Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

(2019) Christian F. Guerrero-Juarez et al.   Nature Communications

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis

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ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

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Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

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A peek into cancer-associated fibroblasts: origins, functions and translational impact

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Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

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Integrating single-cell transcriptomic data across different conditions, technologies, and species

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Mechanisms and impact of altered tumour mechanics

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RSAT 2018: regulatory sequence analysis tools 20th anniversary

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Development of a stress response therapy targeting aggressive prostate cancer

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Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

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Turning foes to friends: targeting cancer-associated fibroblasts

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Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

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Genetic tools for identifying and manipulating fibroblasts in the mouse

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Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

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Tumor-associated fibroblasts predominantly come from local and not circulating precursors

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Pericyte–fibroblast transition promotes tumor growth and metastasis

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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

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ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver

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A novel autoregulatory loop between the Gcn2-Atf4 pathway and L-Proline metabolism controls stem cell identity

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ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

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Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer

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Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

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Melanoma Epidemic: An Analysis of Six Decades of Data From the Connecticut Tumor Registry

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

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Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

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Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

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Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

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ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

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(2012) Mark B. Gerstein et al.   NATURE

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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

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Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1

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Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression

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Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts

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Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

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