Dodecaborate-Encapsulated Extracellular Vesicles with Modification of Cell-Penetrating Peptides for Enhancing Macropinocytotic Cellular Uptake and Biological Activity in Boron Neutron Capture Therapy

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

(2021) Shaojuan Song et al.   Frontiers in Oncology

Biofunctional Peptide-Modified Extracellular Vesicles Enable Effective Intracellular Delivery via the Induction of Macropinocytosis

(2021) Ikuhiko Nakase   Processes

Environmental pH stress influences cellular secretion and uptake of extracellular vesicles

(2021) Ikuhiko Nakase et al.   FEBS Open Bio

Exosomes and Cell Communication: From Tumour-Derived Exosomes and Their Role in Tumour Progression to the Use of Exosomal Cargo for Cancer Treatment

(2021) Andrea Nicolini et al.   Cancers

Macropinocytosis-Inducible Extracellular Vesicles Modified with Antimicrobial Protein CAP18-Derived Cell-Penetrating Peptides for Efficient Intracellular Delivery

(2021) Kosuke Noguchi et al.   MOLECULAR PHARMACEUTICS

Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors

(2020) Pablo Lara et al.   JOURNAL OF NANOBIOTECHNOLOGY

Antibody-Based Receptor Targeting Using an Fc-Binding Peptide-Dodecaborate Conjugate and Macropinocytosis Induction for Boron Neutron Capture Therapy

(2020) Ikuhiko Nakase et al.   ACS Omega

Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era

(2019) Minoru Suzuki   International Journal of Clinical Oncology

Exosomes: Diagnostic Biomarkers and Therapeutic Delivery Vehicles for Cancer

(2019) Liangdi Jiang et al.   MOLECULAR PHARMACEUTICS

Latest advances in extracellular vesicles: from bench to bedside

(2019) Tomofumi Yamamoto et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells

(2019) Tomoya Takenaka et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Label-free detection of hypoxia-induced extracellular vesicle secretion from MCF-7 cells

(2018) Tugba Kilic et al.   Scientific Reports

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

(2017) Akira Yokoi et al.   Nature Communications

Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery

(2017) Ikuhiko Nakase et al.   Scientific Reports

Vectorization of biomacromolecules into cells using extracellular vesicles with enhanced internalization induced by macropinocytosis

(2016) Ikuhiko Nakase et al.   Scientific Reports

Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2

(2015) Printip Wongthai et al.   CANCER SCIENCE

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase Cα

(2014) Ikuhiko Nakase et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

(2014) Hyungsoon Im et al.   NATURE BIOTECHNOLOGY

Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen

(2014) Yusuke Yoshioka et al.   Nature Communications

Critical review, with an optimistic outlook, on Boron Neutron Capture Therapy (BNCT)

(2013) Raymond L. Moss   APPLIED RADIATION AND ISOTOPES

Exosomes as nano-theranostic delivery platforms for gene therapy

(2012) Aaron Tan et al.   ADVANCED DRUG DELIVERY REVIEWS

Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo

(2012) Ikuhiko Nakase et al.   JOURNAL OF CONTROLLED RELEASE

Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer

(2012) Rolf F Barth et al.   Radiation Oncology

Synthesis of optically active dodecaborate-containing l-amino acids for BNCT

(2011) Shintaro Kusaka et al.   APPLIED RADIATION AND ISOTOPES

Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis

(2009) Ikuhiko Nakase et al.   MOLECULAR THERAPY

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY