Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

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Oncometabolites suppress DNA repair by disrupting local chromatin signalling

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Succination inactivates gasdermin D and blocks pyroptosis

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Neddylation of PTEN regulates its nuclear import and promotes tumor development

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Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase

(2019) Mariana A. Ajalla Aleixo et al.   FEBS Journal

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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Fumarate hydratase in cancer: A multifaceted tumour suppressor

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The Metabolic Basis of Kidney Cancer

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PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage

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PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1

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Drug resistance in papillary RCC: from putative mechanisms to clinical practicalities

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Phase II, 2‐stage, 2‐arm, PIK3CA mutation stratified trial of MK‐2206 in recurrent endometrial cancer

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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

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The functions and regulation of the PTEN tumour suppressor: new modes and prospects

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Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

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Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

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Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress

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Experimental imaging in orthotopic renal cell carcinoma xenograft models: comparative evaluation of high-resolution 3D ultrasonography, in-vivo micro-CT and 9.4T MRI

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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

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Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

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Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

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PTEN function: the long and the short of it

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The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

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Genome engineering using the CRISPR-Cas9 system

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Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

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Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

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The functions and regulation of the PTEN tumour suppressor

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Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240

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The emerging role of fumarate as an oncometabolite

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An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

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UOK 262 cell line, fumarate hydratase deficient (FH−/FH−) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

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Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1  Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

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