Review
Pharmacology & Pharmacy
Rui-Fang Dong, Miao-Lin Zhu, Ming-Ming Liu, Yi-Ting Xu, Liu-Liu Yuan, Jing Bian, Yuan-Zheng Xia, Ling-Yi Kong
Summary: The article discusses the mechanisms of EGFR-TKIs resistance induced by secondary EGFR mutations, such as T790M and C797S. It highlights the development of targeted drugs to overcome resistance mediated by EGFR mutations.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Oncology
Ameneh Jafari, Amirhesam Babajani, Meghdad Abdollahpour-Alitappeh, Nayebali Ahmadi, Mostafa Rezaei-Tavirani
Summary: Exosomes, originating from various types of cells, are crucial in cell-to-cell communication and cancer progression. Their unique biogenesis, low immunogenicity, and ability to target tumor cells make them attractive for cancer therapy. Understanding the molecular mechanisms of exosomes' involvement in tumorigenesis is crucial for developing next-generation cancer therapeutics.
Review
Biochemistry & Molecular Biology
Siyuan Luan, Yushang Yang, Yuxin Zhou, Xiaoxi Zeng, Xin Xiao, Bo Liu, Yong Yuan
Summary: Long noncoding RNAs (lncRNAs) play crucial regulatory roles in human cancers, particularly in relation to esophageal carcinoma (EC). They can regulate the expression of oncogenes or tumor suppressors through various mechanisms, exerting unique EC-promoting or EC-suppressive functions. In clinical applications, the features of lncRNAs are utilized for developing novel diagnostic and therapeutic strategies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Oncology
Muhammad Tufail
Summary: This study investigates the significance of DNA repair pathways in breast cancer and explores their potential as targets for cancer treatment. Various pathways such as nucleotide excision repair, base excision repair, mismatch repair, homologous recombination repair, non-homologous end joining, fanconi anemia pathway, translesion synthesis, direct repair, and DNA damage tolerance are examined. The study also explores the role of these pathways in breast cancer resistance.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Biochemistry & Molecular Biology
Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Michael Hsiao, Ming-Shyan Huang, Chih-Jen Yang
Summary: In this review, the authors summarize the mechanisms of FAK-mediated signaling networks during tumor development and the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Qianyu Wang, Xiaofei Shen, Gang Chen, Junfeng Du
Summary: Immunotherapy, particularly immune checkpoint inhibitors (ICIs), offers hope for patients with failed multiline therapy in cancer treatment. However, the benefit is limited to a small subset of patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) metastatic colorectal cancer (mCRC). Resistance to ICIs is observed in 45-60% of dMMR/MSI-H mCRC patients, indicating potential unknown pathways mediating immune escape. Mismatch repair-proficient (pMMR) or microsatellite-stable (MSS) mCRC patients do not benefit from ICIs. This review discusses the mechanisms of action and current status of ICIs in CRC, as well as the mechanisms of primary and acquired resistance and potential therapeutic strategies to overcome resistance in the clinic.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Ping Zhang, Guoyun Wang
Summary: Endometriosis is a disease where endometrial-like tissue grows outside the uterus. Progestins are the most commonly used treatment, but some patients show resistance to these drugs. The mechanisms of this progesterone resistance include abnormal PGR signaling, chronic inflammation, aberrant gene expression, epigenetic alterations, and environmental toxins. Understanding these mechanisms may help develop new therapeutic regimens to reverse progesterone resistance in endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Juan Jin, Yuhao Xie, Jin-Shi Zhang, Jing-Quan Wang, Shi-Jie Dai, Wen-fang He, Shou-Ye Li, Charles R. Ashby Jr, Zhe-Sheng Chen, Qiang He
Summary: Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer, and targeted therapy with Sunitinib has become the main treatment option due to the lack of efficacy in radiation therapy and chemotherapy. However, many patients develop resistance to Sunitinib within months of therapy. In this review, we discuss the molecular mechanisms of Sunitinib resistance, strategies to overcome it, and potential predictive biomarkers.
DRUG RESISTANCE UPDATES
(2023)
Article
Microbiology
Xin-Fei Chen, Han Zhang, Xin-Miao Jia, Jin Cao, Li Li, Xin-Lan Hu, Ning Li, Yu-Ling Xiao, Fei Xia, Li-Yan Ye, Qing-Feng Hu, Xiao-Li Wu, Li-Ping Ning, Po-Ren Hsueh, Xin Fan, Shu-Ying Yu, Jing-Jing Huang, Xiu-Li Xie, Wen-Hang Yang, Ying-Xing Li, Ge Zhang, Jing-Jia Zhang, Si-Meng Duan, Wei Kang, Tong Wang, Jin Li, Meng Xiao, Xin Hou, Ying-Chun Xu
Summary: Candida duobushaemulonii, a closely related species to Candida auris, can cause invasive and non-invasive infections in humans. It shows high resistance to amphotericin B and some resistance to 5-flucytosine.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Oncology
Piera Federico, Emilio Francesco Giunta, Andrea Tufo, Francesco Tovoli, Angelica Petrillo, Bruno Daniele
Summary: Anti-angiogenic drugs in HCC treatment face resistance issues, primary resistance could be due to unique characteristics of HCC, and secondary resistance can be targeted through the discovery of molecular mechanisms. The combination of antiangiogenic therapy plus ICIs shows potential in improving patient survival.
Review
Biochemistry & Molecular Biology
Mitra Behroozaghdam, Maryam Dehghani, Amirhossein Zabolian, Davood Kamali, Salar Javanshir, Farzaneh Hasani Sadi, Mehrdad Hashemi, Teimour Tabari, Mohsen Rashidi, Sepideh Mirzaei, Atefeh Zarepour, Ali Zarrabi, Danielle De Greef, Anupam Bishayee
Summary: Breast cancer is a common cancer in females and finding an effective therapeutic agent is crucial. Resveratrol, a polyphenol found in common foods, has been used to treat various diseases including breast cancer. Its anticancer mechanisms include inhibiting cell proliferation and reducing invasion and metastasis, and it may have synergistic effects when combined with other chemotherapy drugs. Nano drug delivery systems have been introduced to improve its bioavailability.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Microbiology
Yiyun Chen, Josephine C. Moran, Stuart Campbell-Lee, Malcolm J. Horsburgh
Summary: Research has found that sphingosine resistance may be related to the regulation of genes such as SaeSR, VraSR, and CtsR, and there is a possibility of increasing sphingosine resistance through gene mutations. This is of great significance for studying the colonization of staphylococci on skin rich in sphingosine and topical therapeutic applications.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Oncology
Yucheng Dong, Qi He, Xinyu Chen, Fan Yang, Li He, Yongchang Zheng
Summary: Extrachromosomal DNA (ecDNA) is circular DNA that plays a significant role in cancer development and heterogeneity. Advances in detection methods, such as microscopy and sequencing, have greatly improved our understanding of ecDNA's molecular characteristics, functions, mechanisms of formation, and clinical implications in cancer. This review focuses on the role of ecDNA in acquired drug resistance, its potential as a diagnostic and prognostic biomarker, and its significance as a therapeutic target in cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Filipiak-Duliban, Klaudia Brodaczewska, Arkadiusz Kajdasz, Claudine Kieda
Summary: 2D culture as a model for drug testing often fails to mimic in vivo drug responses, while 3D cultures show potential to better model these responses. In this study, we compared 3D and 2D cultures and found that tumor cells in 3D models exhibited higher resistance to anti-cancer drugs, suggesting the presence of new non-canonical mechanisms for drug resistance in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Kun Yao, Hua Liu, Shui Yu, Haohao Zhu, Jie Pan
Summary: This review discusses the resistance mechanisms and preventive strategies of ivosidenib and enasidenib drugs, as well as the opportunities and challenges of developing next-generation mIDH1/2 inhibitors and translating combination therapies into clinical applications.
Article
Oncology
Marcin Kleibert, Iga Plachta, Anna M. Czarnecka, Mateusz J. Spalek, Anna Szumera-Cieckiewicz, Piotr Rutkowski
Summary: Surgical resection is the standard treatment for malignant adnexal cancers of the skin, although the efficacy of radiotherapy and targeted therapies is still uncertain. This study aims to analyze treatment efficacy in patients treated at a reference center and discuss the role of multidisciplinary treatment.
Article
Medicine, General & Internal
Pawel Rogala, Anna M. Czarnecka, Bozena Cybulska-Stopa, Krzysztof Ostaszewski, Karolina Piejko, Marcin Zietek, Robert Dziura, Ewa Rutkowska, Lukasz Galus, Natasza Kempa-Kaminska, Jacek Calik, Agata Salek-Zan, Tomasz Zemelka, Wieslaw Bal, Agnieszka Kamycka, Tomasz Switaj, Grazyna Kaminska-Winciorek, Rafal Suwinski, Jacek Mackiewicz, Piotr Rutkowski
Summary: Limited data is available on the sequencing of targeted therapy and immunotherapy in patients with BRAF-mutant melanoma. This study demonstrates the effectiveness of BRAFi/MEKi therapy as a second-line treatment for advanced melanoma patients, with similar efficacy observed for all combinations of BRAFi/MEKi.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Pawel Rogala, Anna M. Czarnecka, Bozena Cybulska-Stopa, Krzysztof Ostaszewski, Karolina Piejko, Marcin Zietek, Robert Dziura, Ewa Rutkowska, Lukasz Galus, Natasza Kempa-Kaminska, Joanna Seredynska, Wieslaw Bal, Katarzyna Kozak, Anna Surus-Hyla, Tomasz Kubiatowski, Grazyna Kaminska-Winciorek, Rafal Suwinski, Jacek Mackiewicz, Piotr Rutkowski
Summary: This study aimed to evaluate the association between different genotypes of human papillomavirus (HPV) and the risk of cervical cancer in Sichuan province, China.
Article
Oncology
Anna Dawidowska, Paulina Jagodzinska-Mucha, Hanna Kosela-Paterczyk, Sylwia Jaczewska, Pawel Sobczuk, Monika Chelstowska, Maria Kowalska, Honorata Badziak-Sterczewska, Jan Poleszczuk, Piotr Rutkowski, Iwona Lugowska
Summary: This study evaluated the impact of immune-related thyroid adverse events on overall survival rates in patients with melanoma undergoing anti-PD-1 therapy. The results showed that clinically significant hypothyroidism was an independent prognostic factor associated with improved overall survival.
Article
Oncology
Pawel Sobczuk, Huber Batruk, Paulina Wojcik, Krzysztof Iwaniak, Katarzyna Kozak, Piotr Rutkowski
Summary: The current landscape of phase II studies in soft tissue sarcomas (STS) is analyzed in this study, and the impact of statistical design on the results is evaluated. The study finds high heterogeneity in the design of STS phase II trials, mainly in terms of primary endpoints and hypotheses used for sample size calculation. There is a need for standardization that takes into account factors associated with the rarity of the disease, outcomes detected in previous trials and real-life studies, and specific characteristics of new therapeutic agents.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Piotr Rutkowski, Anna M. Czarnecka
ANNALS OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Michal Bereza, Mateusz Dembinski, Agnieszka E. E. Zajac, Jakub Piatkowski, Monika Dudzisz-Sledz, Piotr Rutkowski, Anna M. Czarnecka
Summary: In recent years, there has been significant progress in understanding the role of epigenetic mechanisms in tumor pathology. Various modifications to DNA and histones can impact gene expression and contribute to the development of tumors. MicroRNAs also play a role in regulating gene expression at a post-transcriptional level. This review focuses on the specific case of chondrosarcoma, a rare bone tumor, and summarizes the current understanding of how epigenetic alterations contribute to its pathogenesis and potential therapeutic approaches that target these modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Marcin Zietek, Pawel Teterycz, Jedrzej Wierzbicki, Michal Jankowski, Manuela Las-Jankowska, Wojciech Zegarski, Janusz Piekarski, Dariusz Nejc, Kamil Drucis, Bozena Cybulska-Stopa, Wojciech Lobaziewicz, Katarzyna Galwas, Grazyna Kaminska-Winciorek, Marcin Zdzienicki, Tatsiana Sryukina, Anna Ziobro, Agnieszka Kluz, Anna M. Czarnecka, Piotr Rutkowski
Summary: This study aimed to evaluate treatment strategies in SLNB-positive melanoma patients in real-world practice. It was found that the percentage of patients undergoing CLND decreased while the use of adjuvant treatment increased. Adjuvant therapy prolonged RFS, but CLND did not. Overall, adjuvant systemic treatment should be offered to all eligible patients in a group of SLNB-positive patients, regardless of whether CLND has been performed or not.
Article
Oncology
Anna Szumera-Cieckiewicz, Klaudia Bobak, Mateusz J. Spalek, Kamil Sokol, Michal Wagrodzki, Daria Owczarek, Monika Kawecka, Beata Puton, Hanna Kosela-Paterczyk, Piotr Rutkowski, Anna M. Czarnecka
Summary: In the study of preplanned treatment in soft tissue sarcoma (STS) patients, HIF1a and ?H2AFX were identified as potential biomarkers for predicting pathological response (PR) after neoadjuvant treatment.
Article
Biotechnology & Applied Microbiology
Silvia Vieira, Paulina Strymecka, Luiza Stanaszek, Joana Silva-Correia, Katarzyna Drela, Michal Fiedorowicz, Izabela Malysz-Cymborska, Miroslaw Janowski, Rui Luis Reis, Barbara Lukomska, Piotr Walczak, Joaquim Miguel Oliveira
Summary: This study aims to develop a stable injectable Mn-based methacrylated gellan gum (Mn/GG-MA) hydrogel for real-time monitored cell delivery into the central nervous system. By supplementing GG-MA solutions with paramagnetic Mn2+ ions, the hydrogel can be visualized under Magnetic Resonance Imaging (MRI). Cell-laden hydrogels prepared using the Mn/GG-MA formulations remained viable after 7 days of culture. In vivo tests on immunocompromised mice showed that the injection of Mn/GG-MA solutions resulted in a continuous and traceable hydrogel visible on MRI scans. Overall, the developed formulations are suitable for non-invasive cell delivery techniques and image-guided neurointerventions.
BIOENGINEERING-BASEL
(2023)
Review
Oncology
Natalia Banaszek, Dominika Kurpiewska, Katarzyna Kozak, Piotr Rutkowski, Pawel Sobczuk
Summary: Sarcomas are a challenging and significant clinical problem due to their poor prognosis. The Sonic hedgehog (Shh) signaling pathway has been found to play a key role in the pathogenesis of sarcomas, and inhibition of this pathway may be a potential therapeutic strategy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Weronika Zajac, Julia Drozdz, Weronika Kisielewska, Weronika Karwowska, Monika Dudzisz-Sledz, Agnieszka E. Zajac, Aneta Borkowska, Anna Szumera-Cieckiewicz, Bartlomiej Szostakowski, Piotr Rutkowski, Anna M. Czarnecka
Summary: Dedifferentiated chondrosarcoma is a rare and aggressive type of cancer with poor prognosis and survival rates. It can affect people of any age, but is usually diagnosed among individuals aged 50 or older. There is no standard treatment available and surgery-based approach is often not possible for patients diagnosed at advanced stages. This article provides updated information on genetics, diagnostic procedures, and treatment options for both localized and advanced dedifferentiated chondrosarcoma.
Review
Oncology
Monika Dudzisz-Sledz, Monika Kondracka, Monika Rudzinska, Agnieszka E. Zajac, Wiktoria Firlej, Dorota Sulejczak, Aneta Borkowska, Bartlomiej Szostakowski, Anna Szumera-Cieckiewicz, Jakub Piatkowski, Piotr Rutkowski, Anna M. Czarnecka
Summary: Mesenchymal chondrosarcoma (MCS) is a rare subtype of chondrosarcoma with a poor prognosis. The pathology and therapeutic options for MCS are still unknown due to its low incidence. Potential role of PDGF/PPI3K/AKT, PKC/RAF/MEK/ERK, and pRB pathways, and BCL2 overexpression have been reported in the pathogenesis of MCS. This review summarizes the current knowledge about MCS diagnosis and treatment options, including immunological and molecular biomarkers, prognostic and predictive factors. The novel trends in targeted therapies and ongoing clinical trials using protein kinase inhibitors and DR5 agonists are discussed as possible future focus in MCS treatment studies.
Article
Oncology
Joanna Placzke, Magdalena Rosinska, Pawel Sobczuk, Marcin Zietek, Natasza Kempa-Kaminska, Bozena Cybulska-Stopa, Grazyna Kaminska-Winciorek, Wieslaw Bal, Jacek Mackiewicz, Lukasz Galus, Manuela Las-Jankowska, Michal Jankowski, Robert Dziura, Kamil Drucis, Aneta Borkowska, Tomasz Switaj, Pawel Rogala, Katarzyna Kozak, Anna Klimczak, Paulina Jagodzinska-Mucha, Anna Szumera-Cieckiewicz, Hanna Kosela-Paterczyk, Piotr Rutkowski
Summary: This study aimed to analyze the outcomes of adjuvant treatment in Polish melanoma patients and compare them with international trial results. The results showed that the type of lymph node surgery before adjuvant therapy did not influence the treatment outcomes. Severe treatment-related complications worsened survival, suggesting the need for cautious consideration of toxicity before treatment. The study supports a de-escalating surgery approach in melanoma treatment.
Review
Oncology
Agnieszka E. Zajac, Anna M. Czarnecka, Piotr Rutkowski
Summary: Soft tissue and bone sarcomas are complex to treat, requiring the development of novel therapeutic options. Tumor-associated macrophages (TAMs) have been identified as potential targets for future treatments due to their involvement in the tumor microenvironment of sarcomas. This review summarizes the role of TAMs, their clinical relevance, and ongoing clinical trials in sarcoma treatment.
