Genistein, a tool for geroscience

Physical activity and exercise: Strategies to manage frailty

(2020) Javier Angulo et al.   Redox Biology

Genistein Improves Bone Healing via Triggering Estrogen Receptor Alpha-Mediated Expressions of Osteogenesis-Associated Genes and Consequent Maturation of Osteoblasts

(2020) Gong-Jhe Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isoflavone‐enriched soybean leaves attenuate ovariectomy‐induced osteoporosis in rats by anti‐inflammatory activity

(2020) Cheng‐Liang Xie et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Bioactivity of dietary polyphenols: The role of metabolites

(2019) Simon Vlad Luca et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The free radical theory of frailty: Mechanisms and opportunities for interventions to promote successful aging

(2019) Jose Viña   FREE RADICAL BIOLOGY AND MEDICINE

Management of frailty: opportunities, challenges, and future directions

(2019) Elsa Dent et al.   LANCET

Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances

(2019) Hardeep Singh Tuli et al.   Frontiers in Pharmacology

ANGPTL2 deletion inhibits osteoclast generation by modulating NF-κB/MAPKs/Cyclin pathways

(2018) Wei-Ming Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-6 trans -signalling mediates trabecular, but not cortical, bone loss after ovariectomy

(2018) Leah Lazzaro et al.   BONE

A Free Radical Theory of Frailty

(2018) Jose Viña et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypertension

(2018) Suzanne Oparil et al.   Nature Reviews Disease Primers

Apoptosis and Oxidative Stress in Neurodegenerative Diseases

(2018) Elena Radi et al.   JOURNAL OF ALZHEIMERS DISEASE

Social Dysfunction in Older Age and Relationships with Cognition, Depression, and Apathy: The GreatAGE Study

(2018) Madia Lozupone et al.   JOURNAL OF ALZHEIMERS DISEASE

Recent progress on biocompatible nanocarrier-based genistein delivery systems in cancer therapy

(2018) Nisha Tyagi et al.   JOURNAL OF DRUG TARGETING

Genistein, a Soy Phytoestrogen, Upregulates the Expression of Human Endothelial Nitric Oxide Synthase and Lowers Blood Pressure in Spontaneously Hypertensive Rats

(2018) Hongwei Si et al.   JOURNAL OF NUTRITION

The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility

(2018) Ravichandra Vemuri et al.   Seminars in Immunopathology

Geroprotectors: A Unified Concept and Screening Approaches

(2017) Alexey Moskalev et al.   Aging and Disease

Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer’s Disease

(2016) Vicent Bonet-Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-obesity effects of gochujang products prepared using rice koji and soybean meju in rats

(2016) H. W. Shin et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Molecular and Therapeutic Targets of Genistein in Alzheimer’s Disease

(2016) Kasi Pandima Devi et al.   MOLECULAR NEUROBIOLOGY

The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span

(2016) Felipe Sierra   Cold Spring Harbor Perspectives in Medicine

A Combination of Intravenous Genistein Plus Mg2+Enhances Antihypertensive Effects in SHR by Endothelial Protection and BKCaChannel Inhibition

(2015) Lina Sun et al.   AMERICAN JOURNAL OF HYPERTENSION

Inhibition of TRPM7 Attenuates Rat Aortic Smooth Muscle Cell Proliferation Induced by Angiotensin II

(2015) Meimei Yang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Oxidative Stress Is Related to Frailty, Not to Age or Sex, in a Geriatric Population: Lipid and Protein Oxidation as Biomarkers of Frailty

(2014) Marta Inglés et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease

(2014) Georgia S. Gaki et al.   NEUROMOLECULAR MEDICINE

Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

(2014) N Hasima et al.   Cell Death & Disease

The Effect of Genistein on the Content and Activity of α- and β-Secretase and Protein Kinase C in Aβ-Injured Hippocampal Neurons

(2013) Weiliang Liao et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Transport Mechanisms for Soy Isoflavones and Microbial Metabolites Dihydrogenistein and Dihydrodaidzein Across Monolayers and Membranes

(2013) Shoko KOBAYASHI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Genistein induces oestrogen receptor-α gene expression in osteoblasts through the activation of mitogen-activated protein kinases/NF-κB/activator protein-1 and promotes cell mineralisation

(2013) Mei-Hsiu Liao et al.   BRITISH JOURNAL OF NUTRITION

Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

(2013) Chih-Hao Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Combination of low dose of genistein and daidzein has synergistic preventive effects on isogenic human prostate cancer cells when compared with individual soy isoflavone

(2013) Xin Dong et al.   FOOD CHEMISTRY

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling

(2012) Lei-Guo Ming et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Vascular Effects of Phytoestrogens and Alternative Menopausal Hormone Therapy in Cardiovascular Disease

(2012) V. B. Gencel et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

(2012) J. Eva Selfridge et al.   NEUROBIOLOGY OF DISEASE

Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

(2012) William M. Johnson et al.   Nutrients

Potent genistein derivatives as inhibitors of estrogen receptor alpha-positive breast cancer

(2011) Radharani Marik et al.   CANCER BIOLOGY & THERAPY

Impact and Therapeutic Potential of PPARs in Alzheimers Disease

(2011) Michael T. Heneka et al.   Current Neuropharmacology

Genistein inhibits mitochondrial-targeted oxidative damage induced by beta-amyloid peptide 25–35 in PC12 cells

(2011) Yuan-Di Xi et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Flavonoid binding to human serum albumin

(2010) Alessandro Bolli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Erythrina variegata extract exerts osteoprotective effects by suppression of the process of bone resorption

(2010) Yan Zhang et al.   BRITISH JOURNAL OF NUTRITION

Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice

(2010) Zhuo Fu et al.   ENDOCRINOLOGY

Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by β-amyloid peptides 25–35 in PC12 cells

(2010) Weiwei Ma et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

(2009) Soraya L. Valles et al.   BRAIN RESEARCH

Glutathione—a review on its role and significance in Parkinson’s disease

(2009) Heather L. Martin et al.   FASEB JOURNAL

Inhibitory effect of genistein on agonist-induced modulation of vascular contractility

(2009) Hyun Dong Je et al.   MOLECULES AND CELLS

Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats

(2009) Curt E. Harper et al.   PROSTATE

Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin Modification

(2008) S. Majid et al.   CANCER RESEARCH

Formation of Dopamine Adducts Derived from Brain Polyunsaturated Fatty Acids

(2008) Xuebo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary isoflavones in the prevention of cardiovascular disease – A molecular perspective

(2007) Gerald Rimbach et al.   FOOD AND CHEMICAL TOXICOLOGY