Molecular and Therapeutic Targets of Genistein in Alzheimer’s Disease

Genistein as antioxidant and antibrowning agents in in vivo and in vitro: A review

(2016) Md. Anisur Rahman Mazumder et al.   BIOMEDICINE & PHARMACOTHERAPY

Potential Therapeutic Effects of Oleuropein Aglycone in Alzheimer's Disease

(2016) Miquel Martorell et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer’s Disease

(2016) Vicent Bonet-Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Phytoestrogen consumption and risk for cognitive decline and dementia: With consideration of thyroid status and other possible mediators

(2016) M. Soni et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

(2016) Hua Zhang et al.   Current Opinion in Food Science

Estrogen receptor β in Alzheimer’s disease: From mechanisms to therapeutics

(2015) Liqin Zhao et al.   AGEING RESEARCH REVIEWS

Bioactivity of genistein: A review of in vitro and in vivo studies

(2015) Ajaz Ahmad Ganai et al.   BIOMEDICINE & PHARMACOTHERAPY

Genistein: A Boon for Mitigating Ischemic Stroke

(2015) Seyed Nabavi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Use of Cholinesterase Inhibitors Across All Stages of Alzheimer’s Disease

(2015) William James Deardorff et al.   DRUGS & AGING

Genistein Alleviatesβ-Amyloid-Induced Inflammatory Damage Through Regulating Toll-Like Receptor 4/Nuclear FactorκB

(2015) Weiwei Ma et al.   JOURNAL OF MEDICINAL FOOD

Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation

(2015) Yumi Kohara et al.   PHYSIOLOGY & BEHAVIOR

Interactions between soy isoflavones and other bioactive compounds: a review of their potentially beneficial health effects

(2015) Meng-Lei Xu et al.   PHYTOCHEMISTRY REVIEWS

The tyrosine kinase inhibitor genistein induces the detachment of rotavirus particles from the cell surface

(2015) Tomás López et al.   VIRUS RESEARCH

Genistein and Cancer: Current Status, Challenges, and Future Directions

(2015) Carmela Spagnuolo et al.   Advances in Nutrition

Genistein decreases cellular redox potential, partially suppresses cell growth in HL-60 leukemia cells and sensitizes cells to γ-radiation-induced cell death

(2014) IN GYU KIM et al.   Molecular Medicine Reports

Soy Isoflavone Antagonizes the Oxidative Cerebrovascular Injury Induced by β-Amyloid Peptides 1–42 in Rats

(2014) Yuan-Di Xi et al.   NEUROCHEMICAL RESEARCH

Patient-derived models of acquired resistance can identify effective drug combinations for cancer

(2014) Adam S. Crystal et al.   SCIENCE

Toll-Like Receptors 2, -3 and -4 Prime Microglia but not Astrocytes Across Central Nervous System Regions for ATP-Dependent Interleukin-1β Release

(2014) Laura Facci et al.   Scientific Reports

The Effect of Genistein on the Content and Activity of α- and β-Secretase and Protein Kinase C in Aβ-Injured Hippocampal Neurons

(2013) Weiliang Liao et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Soy Isoflavone Alleviates Aβ1-42-Induced Impairment of Learning and Memory Ability Through the Regulation of RAGE/LRP-1 in Neuronal and Vascular Tissue

(2013) Yuan-Di Xi et al.   CURRENT NEUROVASCULAR RESEARCH

17β-Estradiol and genistein acute treatments improve some cerebral cortex homeostasis aspects deteriorated by aging in female rats

(2013) Javier Morán et al.   EXPERIMENTAL GERONTOLOGY

Beta Amyloid Peptide (25-35) Leading to Inflammation Through Toll-Like Receptors and the Anti-inflammatory Effect of Genistein in BV-2 Cells

(2013) Huan-Ling Yu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Targeting Estrogen Receptors for the Treatment of Alzheimer’s Disease

(2013) Jung Hoon Lee et al.   MOLECULAR NEUROBIOLOGY

Genistein alleviates the mitochondria-targeted DNA damage induced by β-amyloid peptides 25–35 in C6 glioma cells

(2013) Wei-wei Ma et al.   NEUROCHEMICAL RESEARCH

Genistein antagonizes inflammatory damage induced by β-amyloid peptide in microglia through TLR4 and NF-κB

(2013) Xin Zhou et al.   NUTRITION

Amyloid Beta1-40-Induced Astrogliosis and the Effect of Genistein Treatment in Rat: A Three-Dimensional Confocal Morphometric and Proteomic Study

(2013) Maryam Bagheri et al.   PLoS One

Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME

(2012) Zhen Yang et al.   Anti-Cancer Agents in Medicinal Chemistry

Flavonoids Protect Cerebrovascular Endothelial Cells through Nrf2 and PI3K from β-Amyloid Peptide-Induced Oxidative Damage

(2012) Yuan-Di Xi et al.   CURRENT NEUROVASCULAR RESEARCH

Chemical Reaction of Soybean Flavonoids with DNA: A Computational Study Using the Implicit Solvent Model

(2012) Hassan H. Abdallah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain Endogenous Estrogen Levels Determine Responses to Estrogen Replacement Therapy via Regulation of BACE1 and NEP in Female Alzheimer’s Transgenic Mice

(2012) Rena Li et al.   MOLECULAR NEUROBIOLOGY

Terpenoids as Potential Anti-Alzheimer’s Disease Therapeutics

(2012) Ki-Yeol Yoo et al.   MOLECULES

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Genistein inhibits aggregation of exogenous amyloid-beta1–40 and alleviates astrogliosis in the hippocampus of rats

(2011) Maryam Bagheri et al.   BRAIN RESEARCH

Impact and Therapeutic Potential of PPARs in Alzheimers Disease

(2011) Michael T. Heneka et al.   Current Neuropharmacology

Effects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell line

(2011) Meixia Pan et al.   Journal of Nutrition Health & Aging

Genistein and Folic Acid Prevent Oxidative Injury Induced by β-Amyloid Peptide

(2010) Bingjie Ding et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by β-amyloid peptides 25–35 in PC12 cells

(2010) Weiwei Ma et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Soybean Supplementation Helps Reverse Age- and Scopolamine-Induced Memory Deficits in Mice

(2010) Nitin Bansal et al.   JOURNAL OF MEDICINAL FOOD

Neuroprotective Effects of Genistein in Mongolian Gerbils: Estrogen Receptor–β Involvement

(2010) Andrea Donzelli et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Genistein ameliorates learning and memory deficits in amyloid β(1–40) rat model of Alzheimer’s disease

(2010) Maryam Bagheri et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Chemistry and Biochemistry of Dietary Polyphenols

(2010) Rong Tsao   Nutrients

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Recent developments in Alzheimer's disease therapeutics

(2009) Michael S Rafii et al.   BMC Medicine

The Multiple Sclerosis Risk Sharing Scheme Monitoring Study – early results and lessons for the future

(2009) Mark Pickin et al.   BMC Neurology

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

(2009) Soraya L. Valles et al.   BRAIN RESEARCH

Neuroprotective effects of genistein and folic acid on apoptosis of rat cultured cortical neurons induced by β-amyloid 31-35

(2009) Huan-Ling Yu et al.   BRITISH JOURNAL OF NUTRITION

Effects of memantine on cognition in patients with moderate to severe Alzheimer's disease: post-hoc analyses of ADAS-cog and SIB total and single-item scores from six randomized, double-blind, placebo-controlled studies

(2009) Patrizia Mecocci et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Isoflavones Prevent Endoplasmic Reticulum Stress-Mediated Neuronal Degeneration by Inhibiting Tau Hyperphosphorylation in SH-SY5Y Cells

(2009) Youn-Jin Park et al.   JOURNAL OF MEDICINAL FOOD

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

(2009) Lenka Munoz et al.   NEUROPHARMACOLOGY

Multi-targeted therapy of cancer by genistein

(2008) Sanjeev Banerjee et al.   CANCER LETTERS