Review
Biochemistry & Molecular Biology
Levy Tenorio Sousa Domingos, Raquel dos Santos Martins, Leonardo Melo de Lima, Angela Michelato Ghizelini, Antonio Ferreira-Pereira, Fernando Cotinguiba
Summary: Aspergillus unguis is a fungal species found in soils and marine environments, with a variety of compounds and biological activities. Despite the extensive research on its compounds and activities, there is still great potential for further studies on A. unguis, such as metabolic induction for new compound production and determination of new biological activities.
Article
Chemistry, Organic
Karoon Sadorn, Siriporn Saepua, Nantiya Bunbamrung, Nattawut Boonyuen, Somjit Komwijit, Pranee Rachtawee, Pattama Pittayakhajonwut
Summary: In this study, four new diphenyl ethers and one new depsidone were isolated from the endophytic fungus Aspergillus unguis BCC54176, along with eighteen known compounds. These compounds exhibited various biological activities, including antibacterial and anti-phytopathogenic activities, with no cytotoxicity against cancerous and non-cancerous cells.
Article
Chemistry, Medicinal
Cao Van Anh, Joo-Hee Kwon, Jong Soon Kang, Hwa-Sun Lee, Chang-Su Heo, Hee Jae Shin
Summary: In this study, three new phenolic polyketides were isolated from Aspergillus unguis fungi and found to possess significant antibacterial activity and cytotoxicity.
Article
Chemistry, Medicinal
Cao Van Anh, Jong Soon Kang, Byeoung-Kyu Choi, Hwa-Sun Lee, Chang-Su Heo, Hee Jae Shin
Summary: Ten secondary metabolites, including a new compound and a compound isolated from a natural source for the first time, were isolated from two fungal strains. Compounds 9 and 10 showed moderate cytotoxic activity against a panel of cancer cell lines, while compound 1 displayed weak radical scavenging activity without cytotoxicity.
Review
Chemistry, Medicinal
Salar Hafez Ghoran, Fatemeh Taktaz, Seyed Abdulmajid Ayatollahi, Anake Kijjoa
Summary: This review provides a comprehensive overview of anthraquinones and their derivatives reported from marine-derived fungi, covering a range from 2000 to 2021. A total of 296 anthraquinones and their derivatives are summarized and categorized, showcasing their diverse biological activities and proposed biogenetic pathways.
Review
Biochemistry & Molecular Biology
Lixiang Sun, Huannan Wang, Maocai Yan, Chunmei Sai, Zhen Zhang
Summary: Marine fungi Aspergillus sp. is an important source of natural active lead compounds with biological and chemical diversity, and sesquiterpenoids are an extremely important class of bioactive secondary metabolites. This paper reviews the sources, chemical structures, bioactivity, biosynthesis, and druggability evaluation of sesquiterpenoids discovered from marine fungi Aspergillus sp. since 2008.
Article
Microbiology
Xiao Yang, Hongjia Yu, Jinwei Ren, Lei Cai, Lijian Xu, Ling Liu
Summary: Phytopathogens pose a significant threat to crops and human health, but marine-derived fungi offer potential anti-phytopathogenic drugs. A new compound, aspersydosulfoxide A, and several known compounds were isolated from a marine-derived fungus. These compounds showed antimicrobial and antinematodal activities, indicating their potential use in crop protection.
Article
Biochemistry & Molecular Biology
Mallique Qader, K. H. Ahammad Uz Zaman, Zhenquan Hu, Cong Wang, Xiaohua Wu, Shugeng Cao
Summary: A new compound, aspochalasin H1, with unique structural features, was isolated from Aspergillus sp. FT1307. The isolated compounds showed diverse biological activities against pathogenic bacteria and cancer cell lines.
Article
Microbiology
Dongli Lv, Jinmei Xia, Xiaoqing Guan, Qiliang Lai, Beibei Zhang, Jianhui Lin, Zongze Shao, Sulan Luo, Dongting Zhangsun, Jiang-Jiang Qin, Weiyi Wang
Summary: Two new bioactive compounds were isolated from a deep-sea-derived fungus and their structures were determined. Compounds 1, 5-7 exhibited significant inhibition against Staphylococcus aureus, while compound 8 showed potent reduction in cell viability of gastric cancer cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
Cunlei Cai, Yingying Chen, Le Zhou, Naying Gong, Hua Zhang, Changli Sun, Junying Ma, Jianhua Ju
Summary: Three diphenyl ethers (1-3) and a cyclopentenone (4), along with seven known compounds (5-11), were isolated from the fermentation broth of the marine sediment-derived fungus Spiromastix sp. SCSIO F190. Compound 3 and 4 exist as atropisomers and racemates, respectively. These compounds showed activities against various pathogenic bacteria, with compounds 1-4 exhibiting strong activity against Gram-positive bacteria, including methicillin-resistant strains.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Integrative & Complementary Medicine
Zhi-Kai Guo, Wen-Yong Zhu, Li-Xing Zhao, Yan-Chi Chen, Sui-Jun Li, Ping Cheng, Hui-Ming Ge, Ren-Xiang Tan, Rui-Hua Jiao
Summary: Six new bromide depsidones and seven known depsidones were isolated from a fungus derived from ants. These compounds exhibited various bioactivities against phytopathogenic bacteria, with the new bromide compound 4 showing the strongest activity against Xanthomonas oryzae pv. oryzae.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Analytical
Beatriz Sepulveda, Alberto Cornejo, Daniela Barcenas-Perez, Jose Cheel, Carlos Areche
Summary: Lichens are symbiotic organisms that produce secondary compounds. Using hyphenated techniques, 25 compounds were detected from Antarctic lichen, including two new compounds and 10 phenolic compounds that were found for the first time in the Cladonia genus.
Article
Chemistry, Physical
Rahul Chandra Mishra, Rishu Kalra, Rahul Dilawari, Mayurika Goel, Colin J. Barrow
Summary: This study bio-fabricated gold nanoparticles (GNP023) using the methanolic extract of Aspergillus terreus. The GNP023 exhibited antimicrobial activity and significant antioxidant properties, making them a potential candidate against food-borne pathogens.
Article
Chemistry, Medicinal
Sung Chul Park, Jung-Ho Lee, Ji-Yeon Hwang, Oh-Seok Kwon, Lijuan Liao, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin
Summary: The compound Ochraceopetalin and its components were isolated from a marine-derived fungus. Ochraceopetalin exhibited significant cytotoxicity against K562 and A549 cells.
Review
Biochemistry & Molecular Biology
Sabrin R. M. Ibrahim, Alaa Sirwi, Basma G. Eid, Shaimaa G. A. Mohamed, Gamal A. Mohamed
Summary: This review provides an overview of fungal depsides from 1975 to 2020, including their sources, biosynthesis, physical and spectral data, and bioactivities. A total of 110 metabolites and more than 122 references have been confirmed in this first review of these multi-faceted metabolites from fungi.
Article
Engineering, Electrical & Electronic
Yang Wu, Bai Chen, Kai Liu, Shan Huang, Yan Li, Jiabin Jia, Jiafeng Yao
Summary: A hierarchical block sparse Bayesian learning (BSBL) method is proposed for lung respiratory monitoring with electrical impedance tomography (EIT), which shows excellent modeling capability and noise robustness. The proposed method outperforms existing methods in terms of reconstruction accuracy and computational time, further improving the feasibility of EIT in respiratory clinical applications.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Plant Sciences
Yingying Song, Yanhui Tan, Jianglian She, Chunmei Chen, Jiamin Wang, Yiwei Hu, Xiaoyan Pang, Junfeng Wang, Yonghong Liu
Summary: In this study, seven new tanzawaic acid derivatives and one new benzene derivative were isolated from a marine algicolous fungus. The structures and configurations of these compounds were determined by various analysis methods. Three compounds showed inhibitory activity on LPS-induced NF-κB, and one compound could suppress RANKL-induced osteoclast differentiation in BMMCs. This is the first report of osteoclastogenesis inhibitory activity for tanzawaic acid derivatives.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Nanoscience & Nanotechnology
Chao Lu, Youzhen Li, Wenchao Zhu, Yan Yang, Kai Liu, Qingtao Li, Meng Gao
Summary: A self-monitoring theranostic probe TPATCF-S has been developed, which can release H2S quickly under water stimuli and monitor the release by a color change. The TPATCF-S absorbed on alginate dressings can be used for wound exudate-responsive release of H2S to efficiently promote skin wound healing.
ACS APPLIED BIO MATERIALS
(2023)
Review
Chemistry, Medicinal
Jiaqi Liang, Jianglian She, Jun Fu, Jiamin Wang, Yuxiu Ye, Bin Yang, Yonghong Liu, Xuefeng Zhou, Huaming Tao
Summary: Microorganisms from sponges have a significant impact on their nutrition and structure. Many novel secondary metabolites with specific activities have been identified from these microorganisms. With the rise of drug-resistant bacteria, it is important to discover new antimicrobial agents. This review highlights 270 secondary metabolites with potential antimicrobial activity, including 124 new compounds and 146 known compounds, that can be used for the development of antimicrobial drugs.
Article
Chemistry, Medicinal
Xiaolin Li, Tianrong Xun, Huayan Xu, Xiaoyan Pang, Bin Yang, Junfeng Wang, Xuefeng Zhou, Xiuping Lin, Suiyi Tan, Yonghong Liu, Shengrong Liao
Summary: Fourteen novel 3,6-diunsaturated 2,5-diketopiperazine derivatives, along with two known ones, were designed and synthesized based on marine natural products. These derivatives showed moderate to good anticancer capacities against A549 and Hela cancer cells. Compound 11 exhibited strong inhibitory activities and could induce apoptosis and block cell cycle progression in both cell lines.
Article
Engineering, Multidisciplinary
Kexin Zuo, Yingru Zhang, Kai Liu, Jian Li, Yangwei Wang
Summary: In this paper, a flexible finger rehabilitation robot driven by shape memory alloy wire was proposed and equipped with a range extender of shape memory alloy wire wiring. The structural design was optimized by exploring the movement mechanism of the finger joint to imitate the normal motion function of the human finger. The prototype of the finger rehabilitation robot was made and tested, showing a maximum joint angle of about 85% of healthy individuals when driven by a 20V voltage, successfully assisting patients in grasping daily objects and meeting the basic requirements of finger rehabilitation.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Huimin Li, Jieyi Long, Xueni Wang, Jianglian She, Yonghong Liu, Yunqiu Li, Bin Yang
Summary: Chemical investigations of Penicillium sp. SCSIO 41038 led to the discovery of a new cyclopiazonic acid-type alkaloid, speradine I (1), and a new phloroglucinol derivative, speradine J (8), along with 13 known compounds. The structures of these compounds were determined through extensive spectroscopic analysis and comparison with literature data. In vitro evaluations showed that all the compounds had antitumor (22Rv1 and PC-3) and enzyme inhibitory activity against acetylcholinesterase (AChE).
NATURAL PRODUCT RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Kai Liu, Yuxing Wei, Hai-Sheng Li
Summary: This paper proposes three types of linear gray transformation schemes for quantum images based on the generalized model of novel enhanced quantum image representation (GNEQR), and constructs the quantum circuits that realize these three transformation methods according to the schemes. The proposed circuits take advantage of efficient quantum arithmetic operations and parallel Controlled-NOT modules to factor classical transformations into basic unitary operators. The feasibility of the schemes is verified on IBM platform using a small size quantum image, and the analysis shows the superiority of the quantum algorithm in both spatial complexity and time complexity compared to the classical algorithm. Furthermore, the effectiveness of the proposed scheme is demonstrated by a clarity evaluation method.
QUANTUM MACHINE INTELLIGENCE
(2023)
Article
Agriculture, Multidisciplinary
Axiu Mao, Meilu Zhu, Endai Huang, Xi Yao, Kai Liu
Summary: Automated animal activity recognition (AAR) has made significant progress in livestock management efficiency, animal health, and welfare monitoring. However, the energy consumption and battery life of sensing devices limit the reduction of the sampling rate in practical applications. This study proposes a novel method that uses knowledge from high-sampling-rate data to improve the performance of AAR at low sampling rates.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2023)
Article
Agriculture, Multidisciplinary
Haiming Gan, Jingfeng Guo, Kai Liu, Xinru Deng, Hui Zhou, Dehuan Luo, Shiyun Chen, Tomas Norton, Yueju Xue
Summary: An action density estimation network (ADEN) was proposed for counting the events of piglet suckling and analyzing suckling behavior. The results showed that ADEN achieved high accuracy in predicting the number of suckling events in both short and long videos. This method is important for evaluating piglet nutrient ingestion, health, welfare, and affinity with the sow.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2023)
Review
Agriculture, Multidisciplinary
Axiu Mao, Endai Huang, Xiaoshuai Wang, Kai Liu
Summary: Animal behavior is an essential indicator of animal health and welfare, and automated animal activity recognition (AAR) based on wearable sensors and deep learning algorithms allows real-time monitoring of animal behavior. This paper provides a comprehensive summary of recent research in AAR, including commonly used sensors, studied species and activities, deep learning algorithms, and available datasets. The review also discusses challenges in developing deep learning models for AAR and proposes potential solutions and future research directions. The accurate and quantitative results obtained by automated AAR systems, combined with the assessment of veterinary specialists, have the potential to significantly improve animal health and welfare.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2023)
Article
Agriculture, Multidisciplinary
Endai Huang, Axiu Mao, Junhui Hou, Yongjian Wu, Weitao Xu, Maria Camila Ceballos, Thomas D. Parsons, Kai Liu
Summary: Computer vision enables monitoring of animal behavior, health, and welfare, and instance segmentation is a high-precision method for detecting individual animals of interest. This paper proposes a new method, CClusnet-Inseg, which adapts a Center Clustering Network for instance segmentation and achieves superior performance compared to other methods.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2023)
Article
Chemistry, Medicinal
Yingying Song, Jianglian She, Weihao Chen, Jiamin Wang, Yanhui Tan, Xiaoyan Pang, Xuefeng Zhou, Junfeng Wang, Yonghong Liu
Summary: Five new fusarin derivatives and two known natural products were isolated from a marine algicolous fungus. These compounds showed various activities including antioxidant, antibacterial, and anti-inflammatory effects, with compound 1 exhibiting good radical scavenging and anti-inflammatory activity.
Article
Chemistry, Medicinal
Ying Chen, Yanchun He, Xiaoyan Pang, Xuefeng Zhou, Yonghong Liu, Bin Yang
Summary: Four previously uncharacterized compounds and twelve known compounds were isolated from the coral-derived fungus Aspergillus austwickii SCSIO41227 from Beibu Gulf. The compounds were analyzed for their structures and enzyme inhibitory activities, and two compounds showed notable inhibitory effects on neuraminidase.
Review
Biochemistry & Molecular Biology
Xiaolin Li, Huayan Xu, Yuyue Li, Shengrong Liao, Yonghong Liu
Summary: The increasing number of unique secondary metabolites from marine microorganisms has attracted the interest of natural product chemists. Cultivating microorganisms in co-culture is a promising strategy for enhancing chemical diversity and discovering novel metabolites. This review focuses on marine-derived co-culture microorganisms, selection and fermentation methods, screening approaches, and the challenges and prospects of co-culture.