Journal
FRONTIERS IN MICROBIOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2022.950857
Keywords
Aspergillus; cytotoxic; antibacterial; NMR; indole diketopiperazine
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Two new bioactive compounds were isolated from a deep-sea-derived fungus and their structures were determined. Compounds 1, 5-7 exhibited significant inhibition against Staphylococcus aureus, while compound 8 showed potent reduction in cell viability of gastric cancer cells.
Two new indole diketopiperazines (1-2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3-11). The structures of 1-2 were assigned based on NMR, MS, NMR calculation, DP4+ analysis, and ECD calculation. The bioactive assay showed that compounds 1, 5-7 significantly inhibited the growth of Staphylococcus aureus. Meanwhile, compound 8 potently reduced the cell viability of gastric cancer cell MKN1 with an IC50 value of 4.6 mu M.
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