Journal
MATERIALS
Volume 15, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ma15113877
Keywords
endophytic fungi; Aspergillus sp; gold nanoparticles; antibacterial; antifungal
Categories
Funding
- Energy and Resources Institute, India
- Deakin University, Australia
- Deakin University HDR scholarship [217450416]
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This study bio-fabricated gold nanoparticles (GNP023) using the methanolic extract of Aspergillus terreus. The GNP023 exhibited antimicrobial activity and significant antioxidant properties, making them a potential candidate against food-borne pathogens.
Gold nanoparticles (GNP) were bio-fabricated utilizing the methanolic extract of the endophytic isolate Aspergillus terreus. The biosynthesised gold nanoparticles (GNP023) were characterised using UV-visible spectroscopy (UV-Vis); transmission electron microscopy (TEM), Fourier-transform nfrared spectroscopy (FTIR) and X-ray diffraction (XRD) studies. The bio-fabricated GNP023 displayed a sharp SPR peak at 536 nm, were spherically shaped, and had an average size between 10-16 nm. The EDX profile confirmed the presence of gold (Au), and XRD analysis confirmed the crystalline nature of GNP023. The antimicrobial activity of GNP023 was investigated against several food-borne and phytopathogens, using in vitro antibacterial and antifungal assays. The maximum zone of inhibition was observed for S. aureus and V. cholera at 400 mu g /mL, whereas inhibition in radial mycelial growth was observed against Fusarium oxysporum and Rhizoctonia solani at 52.5% and 65.46%, respectively, when challenged with GNP023 (200 mu g/mL). Moreover, the gold nanoparticles displayed significant antioxidant activity against the ABTS radical, with an IC50 of 38.61 mu g/mL, and were non-toxic when tested against human kidney embryonic 293 (HEK293) cells. Thus, the current work supports the application of myco-synthesised gold nanoparticles as a versatile antimicrobial candidate against food-borne pathogens.
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