Ttc21b deficiency attenuates autosomal dominant polycystic kidney disease in a kidney tubular- and maturation-dependent manner.

The morbid genome of ciliopathies: an update

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Genetic reduction of cilium length by targeting intraflagellar transport 88 protein impedes kidney and liver cyst formation in mouse models of autosomal polycystic kidney disease

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OGT knockdown counteracts high phosphate-induced vascular calcification in chronic kidney disease through autophagy activation by downregulating YAP

(2020) Tian-Hua Xu et al.   LIFE SCIENCES

O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis

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Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway

(2020) Vasileios Gerakopoulos et al.   Life Science Alliance

Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation

(2019) Su Fu (MD) et al.   OSTEOARTHRITIS AND CARTILAGE

Tolvaptan: A Review in Autosomal Dominant Polycystic Kidney Disease

(2019) Hannah A. Blair   DRUGS

Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia

(2019) Sun-Hee Hwang et al.   CURRENT BIOLOGY

Tulp3 Is a Ciliary Trafficking Gene that Regulates Polycystic Kidney Disease

(2019) Emilie Legué et al.   CURRENT BIOLOGY

O-GlcNAcylation of RAF1 increases its stabilization and induces the renal fibrosis

(2019) Du Feng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease

(2019) Wouter N. Leonhard et al.   EBioMedicine

Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model

(2019) Rebecca V. Walker et al.   Nature Communications

Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease

(2019) Jacob A. Torres et al.   Cell Metabolism

Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

(2018) Amandine Viau et al.   EMBO JOURNAL

O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats

(2018) Rodrigo Pacheco Silva-Aguiar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lkb1 deficiency confers glutamine dependency in polycystic kidney disease

(2018) Ebony M. Flowers et al.   Nature Communications

Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells

(2018) Luciane M. Silva et al.   Scientific Reports

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

(2018) Xiaowen Liu et al.   eLife

Many Genes—One Disease? Genetics of Nephronophthisis (NPHP) and NPHP-Associated Disorders

(2018) Shalabh Srivastava et al.   Frontiers in Pediatrics

Prevalence Estimates of Polycystic Kidney and Liver Disease by Population Sequencing

(2018) Matthew B. Lanktree et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia

(2018) Sarina Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

O-GlcNAc as an Integrator of Signaling Pathways

(2018) Qunxiang Ong et al.   Frontiers in Endocrinology

Augmented O-GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast-induced acute kidney injury in rats

(2017) Jiachang Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors

(2017) Tomoaki Hirano et al.   MOLECULAR BIOLOGY OF THE CELL

Role for the IFT-A Complex in Selective Transport to the Primary Cilium

(2016) Wenxiang Fu et al.   Cell Reports

AlteringO-Linked β-N-Acetylglucosamine Cycling Disrupts Mitochondrial Function

(2014) Ee Phie Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered trafficking and stability of polycystins underlie polycystic kidney disease

(2014) Yiqiang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

The Cleaved Cytoplasmic Tail of Polycystin-1 Regulates Src-Dependent STAT3 Activation

(2014) J. J. Talbot et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Homozygous Missense Mutation in the Ciliary Gene TTC21B Causes Familial FSGS

(2014) E. H. Cong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models

(2014) P. V. Tran et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells

(2014) Viralkumar S. Upadhyay et al.   Frontiers in Physiology

Reduced Ciliary Polycystin-2 in Induced Pluripotent Stem Cells from Polycystic Kidney Disease Patients with PKD1 Mutations

(2013) B. S. Freedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

(2013) Ming Ma et al.   NATURE GENETICS

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

(2013) Isaline Rowe et al.   NATURE MEDICINE

Direct confocal acquisition of fluorescence from X-gal staining on thick tissue sections

(2013) Konstantin L. Levitsky et al.   Scientific Reports

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response

(2012) A. K. T. Wann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking

(2012) Karel F. Liem et al.   JOURNAL OF CELL BIOLOGY

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

(2012) Katharina Hopp et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation

(2012) J. A. Jonassen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

(2012) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways

(2011) Ayumi Takakura et al.   HUMAN MOLECULAR GENETICS

TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum

(2011) Erica E Davis et al.   NATURE GENETICS

Ciliogenesis in normal human kidney development and post-natal life

(2011) Mirna Saraga-Babić et al.   PEDIATRIC NEPHROLOGY

Polycystin-1 regulates STAT activity by a dual mechanism

(2011) J. J. Talbot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

(2011) J. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

(2010) Tatiana Y. Besschetnova et al.   CURRENT BIOLOGY

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain

(2009) R.W. Stottmann et al.   DEVELOPMENTAL BIOLOGY

Evidence of O-linked N-acetylglucosamine in diabetic nephropathy

(2009) Péter Degrell et al.   LIFE SCIENCES

THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

(2008) Pamela V Tran et al.   NATURE GENETICS