Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia

Amplifying Free Radical Generation of AIE Photosensitizer with Small Singlet–Triplet Splitting for Hypoxia-Overcoming Photodynamic Therapy

(2022) Ya-Fang Xiao et al.   ACS Applied Materials & Interfaces

Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia

(2022) Shi Kuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

(2021) Razan Alzeibak et al.   Journal for ImmunoTherapy of Cancer

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Fine‐feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity †

(2021) Houston D. Cole et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes

(2021) Austin C. Hachey et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Relevance of the electron transfer pathway in photodynamic activity of Ru(ii) polypyridyl complexes containing 4,7-diphenyl-1,10-phenanthroline ligands under normoxic and hypoxic conditions

(2021) Olga Mazuryk et al.   DALTON TRANSACTIONS

Anticancer Agent with Inexplicable Potency in Extreme Hypoxia: Characterizing a Light-Triggered Ruthenium Ubertoxin

(2021) Houston D. Cole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward Optimal Ru(II) Photocages: Balancing Photochemistry, Stability, and Biocompatibility Through Fine Tuning of Steric, Electronic, and Physiochemical Features

(2020) Dmytro Havrylyuk et al.   INORGANIC CHEMISTRY

Dual-Action Ru(II) Complexes with Bulky π-Expansive Ligands: Phototoxicity without DNA Intercalation

(2020) Nicholas P. Toupin et al.   INORGANIC CHEMISTRY

Photodynamic Therapy and Immunity: An Update

(2020) Riddhi Falk‐Mahapatra et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Recent progress in ligand photorelease reaction mechanisms: Theoretical insights focusing on Ru(II) 3MC states

(2020) Adrien Soupart et al.   COORDINATION CHEMISTRY REVIEWS

NIR‐absorbing Ru(II) Complexes Containing α‐Oligothiophenes for Applications in Photodynamic Therapy

(2020) Sherri Mcfarland et al.   CHEMBIOCHEM

Photophysical Investigation of Iron(II) Complexes Bearing Bidentate Annulated Isomeric Pyridine-NHC Ligands

(2020) Kevin Magra et al.   Journal of Physical Chemistry C

TLD1433-Mediated Photodynamic Therapy with an Optical Surface Applicator in the Treatment of Lung Cancer Cells In Vitro

(2020) Sarah Chamberlain et al.   Pharmaceuticals

Photodynamic therapy, priming and optical imaging: Potential co-conspirators in treatment design and optimization — a Thomas Dougherty Award for Excellence in PDT paper

(2020) Pushpamali De Silva et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

MicroRNAs, Hypoxia and the Stem-Like State as Contributors to Cancer Aggressiveness

(2019) Lucy Wanjiku Macharia et al.   Frontiers in Genetics

The capability and potential of new forms of personalized colon cancer treatment: Immunotherapy and Photodynamic Therapy

(2019) Marta Kaleta-Richter et al.   Photodiagnosis and Photodynamic Therapy

Predictive Strength of Photophysical Measurements for in Vitro Photobiological Activity in a Series of Ru(II) Polypyridyl Complexes Derived from π-Extended Ligands

(2019) Christian Reichardt et al.   INORGANIC CHEMISTRY

Impact of the fac/mer Isomerism on the Excited-State Dynamics of Pyridyl-carbene Fe(II) Complexes

(2019) Kevin Magra et al.   INORGANIC CHEMISTRY

Geodesic interpolation for reaction pathways

(2019) Xiaolei Zhu et al.   JOURNAL OF CHEMICAL PHYSICS

Low dose photodynamic therapy harmonizes with radiation therapy to induce beneficial effects on pancreatic heterocellular spheroids

(2019) Anne-Laure Bulin et al.   Oncotarget

Diastereoselective Synthesis and Two-Step Photocleavage of Ruthenium Polypyridyl Complexes Bearing a Bis(thioether) Ligand

(2019) Michael S. Meijer et al.   INORGANIC CHEMISTRY

Photophysical Properties and Photobiological Activities of Ruthenium(II) Complexes Bearing π-Expansive Cyclometalating Ligands with Thienyl Groups

(2019) Julia McCain et al.   INORGANIC CHEMISTRY

NIR-Light-Driven Generation of Reactive Oxygen Species Using Ru(II)-Decorated Lipid-Encapsulated Upconverting Nanoparticles

(2019) Michael S. Meijer et al.   LANGMUIR

Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model

(2019) Vincent H. S. van Rixel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T‐Cell Repertoire

(2019) Shubhankar Nath et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions

(2019) John Roque et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Ru(II) Polypyridyl Complexes Derived from Tetradentate Ancillary Ligands for Effective Photocaging

(2018) Ao Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

Photoactivation of imatinib–antibody conjugate using low-energy visible light from Ru(ii)-polypyridyl cages

(2018) Thomas N. Rohrabaugh et al.   CHEMICAL COMMUNICATIONS

Ru(ii) polypyridyl complexes as photocages for bioactive compounds containing nitriles and aromatic heterocycles

(2018) Ao Li et al.   CHEMICAL COMMUNICATIONS

New RuII Scaffold for Photoinduced Ligand Release with Red Light in the Photodynamic Therapy (PDT) Window

(2018) Lauren M. Loftus et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cyclometalated Ruthenium(II) Complexes Derived from α-Oligothiophenes as Highly Selective Cytotoxic or Photocytotoxic Agents

(2018) Goutam Ghosh et al.   INORGANIC CHEMISTRY

Role of cell stress signaling networks in cancer cell death and antitumor immune response following proteotoxic injury inflicted by photodynamic therapy

(2018) Mladen Korbelik   LASERS IN SURGERY AND MEDICINE

Bacterial Cytological Profiling Reveals the Mechanism of Action of Anticancer Metal Complexes

(2018) Yang Sun et al.   MOLECULAR PHARMACEUTICS

Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy

(2018) Peter H. Ahn et al.   Photodiagnosis and Photodynamic Therapy

Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process

(2018) Zhuang Lv et al.   Chemical Science

New Ru(ii) photocages operative with near-IR light: new platform for drug delivery in the PDT window

(2018) Malik H. Al-Afyouni et al.   Chemical Science

Red-Light-Controlled Release of Drug-Ru Complex Conjugates from Metallopolymer Micelles for Phototherapy in Hypoxic Tumor Environments

(2018) Wen Sun et al.   ADVANCED FUNCTIONAL MATERIALS

Synthesis and Computational Study of a Pyridylcarbene Fe(II) Complex: Unexpected Effects of fac/mer Isomerism in Metal-to-Ligand Triplet Potential Energy Surfaces

(2018) Antonio Francés-Monerris et al.   INORGANIC CHEMISTRY

Synthesis, Characterization, and Photobiological Studies of Ru(II) Dyads Derived from α -Oligothiophene Derivatives of 1,10-Phenanthroline

(2018) Susan Monro et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433

(2018) Susan Monro et al.   CHEMICAL REVIEWS

Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers

(2018) Karan Arora et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma

(2018) Stephanie R. Rice et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Photochemical Properties and Structure-Activity Relationships of RuIIComplexes with Pyridylbenzazole Ligands as Promising Anticancer Agents

(2017) Dmytro Havrylyuk et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Photochemical and Photobiological Activity of Ru(II) Homoleptic and Heteroleptic Complexes Containing Methylated Bipyridyl-type Ligands

(2017) Lars Kohler et al.   INORGANIC CHEMISTRY

Influence of the Steric Bulk and Solvent on the Photoreactivity of Ruthenium Polypyridyl Complexes Coordinated to l-Proline

(2017) Jordi-Amat Cuello-Garibo et al.   INORGANIC CHEMISTRY

DFT Investigation of Ligand Photodissociation in [RuII(tpy)(bpy)(py)]2+ and [RuII(tpy)(Me2bpy)(py)]2+ Complexes

(2017) Khalin Nisbett et al.   INORGANIC CHEMISTRY

Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy

(2017) Ishna N. Mistry et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Excited State Dynamics of a Photobiologically Active Ru(II) Dyad Are Altered in Biologically Relevant Environments

(2017) Christian Reichardt et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Trajectory Surface-Hopping Dynamics Including Intersystem Crossing in [Ru(bpy)3]2+

(2017) Andrew J. Atkins et al.   Journal of Physical Chemistry Letters

Software update: the ORCA program system, version 4.0

(2017) Frank Neese   Wiley Interdisciplinary Reviews-Computational Molecular Science

Interstitial Photodynamic Therapy—A Focused Review

(2017) Gal Shafirstein et al.   Cancers

Photodynamic Therapy and Antitumor Immunity

(2017) Sandra O. Gollnick   Journal of the National Comprehensive Cancer Network

A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control

(2016) Weipei Feng et al.   CHEMICAL COMMUNICATIONS

Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition

(2016) Matthew Huisman et al.   CHEMICAL COMMUNICATIONS

New RuIIComplex for Dual Activity: Photoinduced Ligand Release and1O2Production

(2016) Lauren M. Loftus et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pivotal Role of a Pentacoordinate 3MC State on the Photocleavage Efficiency of a Thioether Ligand in Ruthenium(II) Complexes: A Theoretical Mechanistic Study

(2016) Adrien J. Göttle et al.   INORGANIC CHEMISTRY

Effects of Methyl Substitution in Ruthenium Tris(2-pyridylmethyl)amine Photocaging Groups for Nitriles

(2016) Karan Arora et al.   INORGANIC CHEMISTRY

Theoretical Exploration of Type I/Type II Dual Photoreactivity of Promising Ru(II) Dyads for PDT Approach

(2016) Marta Erminia Alberto et al.   INORGANIC CHEMISTRY

Strained ruthenium metal–organic dyads as photocisplatin agents with dual action

(2016) Tariq Sainuddin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives

(2016) Yamin Yang et al.   Oxidative Medicine and Cellular Longevity

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer

(2016) Matthew Dickerson et al.   Journal of Materials Chemistry B

Ru(II) dyads derived from α -oligothiophenes: A new class of potent and versatile photosensitizers for PDT

(2015) Ge Shi et al.   COORDINATION CHEMISTRY REVIEWS

Organometallic Ru(II) Photosensitizers Derived from π-Expansive Cyclometalating Ligands: Surprising Theranostic PDT Effects

(2015) Tariq Sainuddin et al.   INORGANIC CHEMISTRY

The heavy atom effect on Zn(ii) phthalocyanine derivatives: a theoretical exploration of the photophysical properties

(2015) Marta E. Alberto et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A Light-Activated Metal Complex Targets both DNA and RNA in a Fluorescent in Vitro Transcription and Translation Assay

(2014) David K. Heidary et al.   CHEMBIOCHEM

Binding of a Ruthenium Complex to a Thioether Ligand Embedded in a Negatively Charged Lipid Bilayer: A Two-Step Mechanism

(2014) Azadeh Bahreman et al.   CHEMISTRY-A EUROPEAN JOURNAL

In Vitro Multiwavelength PDT with 3IL States: Teaching Old Molecules New Tricks

(2014) Huimin Yin et al.   INORGANIC CHEMISTRY

Photoactive Ru(II) Complexes With Dioxinophenanthroline Ligands Are Potent Cytotoxic Agents

(2014) Achmad N. Hidayatullah et al.   INORGANIC CHEMISTRY

Ru(II) Dyads Derived from 2-(1-Pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline: Versatile Photosensitizers for Photodynamic Applications

(2014) Mat Stephenson et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Unusually Efficient Pyridine Photodissociation from Ru(II) Complexes with Sterically Bulky Bidentate Ancillary Ligands

(2014) Jessica D. Knoll et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Efficacy and safety of continuous low-irradiance photodynamic therapy in the treatment of chest wall progression of breast cancer

(2014) Sara A. Morrison et al.   JOURNAL OF SURGICAL RESEARCH

Spontaneous Formation in the Dark, and Visible Light-Induced Cleavage, of a Ru–S Bond in Water: A Thermodynamic and Kinetic Study

(2013) Azadeh Bahreman et al.   INORGANIC CHEMISTRY

Selective Photoinduced Ligand Exchange in a New Tris–Heteroleptic Ru(II) Complex

(2013) Bryan A. Albani et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Exploitation of Long-Lived 3IL Excited States for Metal–Organic Photodynamic Therapy: Verification in a Metastatic Melanoma Model

(2013) Richard Lincoln et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Experimental Evidence of Ultrafast Quenching of the 3MLCT Luminescence in Ruthenium(II) Tris-bipyridyl Complexes via a 3dd State

(2013) Qinchao Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immune Response Against Angiosarcoma Following Lower Fluence Rate Clinical Photodynamic Therapy

(2012) Patricia S.P. Thong et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents

(2012) Brock S. Howerton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Killing Hypoxic Cell Populations in a 3D Tumor Model with EtNBS-PDT

(2011) Conor L. Evans et al.   PLoS One

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

(2010) Jonathan P. Celli et al.   CHEMICAL REVIEWS

Singlet oxygen: there is still something new under the sun, and it is better than ever

(2010) Peter R. Ogilby   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Enhanced Systemic Immune Reactivity to a Basal Cell Carcinoma Associated Antigen Following Photodynamic Therapy

(2009) E. Kabingu et al.   CLINICAL CANCER RESEARCH

Enhancement of anti-tumor immunity by photodynamic therapy

(2009) Sandra O. Gollnick et al.   IMMUNOLOGIC RESEARCH

Reevaluation of absolute luminescence quantum yields of standard solutions using a spectrometer with an integrating sphere and a back-thinned CCD detector

(2009) Kengo Suzuki et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS