Preventing Alzheimer's disease by means of natural selection

Aerobic Glycolysis in the Human Brain Is Associated with Development and Neotenous Gene Expression

(2014) Manu S. Goyal et al.   Cell Metabolism

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer’s as a metabolic disease

(2013) Lloyd A. Demetrius et al.   BIOGERONTOLOGY

The inverse association of cancer and Alzheimer's: a bioenergetic mechanism

(2013) L. A. Demetrius et al.   Journal of the Royal Society Interface

Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders

(2013) Rafael Tabarés-Seisdedos et al.   NATURE REVIEWS NEUROSCIENCE

Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome

(2013) Mak Adam Daulatzai   NEUROTOXICITY RESEARCH

Boltzmann, Darwin and Directionality theory

(2013) Lloyd A. Demetrius   PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS

Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease

(2013) T. L. S. Benzinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Interactive Effect of Apolipoprotein E Genotype and Age on Hippocampal Activation During Memory Processing in Healthy Adults

(2012) Lisa M. Nichols et al.   ARCHIVES OF GENERAL PSYCHIATRY

An inverse-Warburg effect and the origin of Alzheimer’s disease

(2012) Lloyd A. Demetrius et al.   BIOGERONTOLOGY

New Evidence of Neuroprotection by Lactate after Transient Focal Cerebral Ischaemia: Extended Benefit after Intracerebroventricular Injection and Efficacy of Intravenous Administration

(2012) Carole Berthet et al.   CEREBROVASCULAR DISEASES

OXPHOS mutations and neurodegeneration

(2012) Werner J H Koopman et al.   EMBO JOURNAL

The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer’s disease

(2012) Pedro M. Pimentel-Coelho et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly

(2012) Hwamee Oh et al.   HUMAN BRAIN MAPPING

Endothelial Cell-Derived Nitric Oxide Enhances Aerobic Glycolysis in Astrocytes via HIF-1 -Mediated Target Gene Activation

(2012) B. Brix et al.   JOURNAL OF NEUROSCIENCE

Sodium L-lactate differently affects brain-derived neurothrophic factor, inducible nitric oxide synthase, and heat shock protein 70 kDa production in human astrocytes and SH-SY5Y cultures

(2012) Marinella Coco et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation

(2012) Alessandra Bulbarelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Functional integration of parietal lobe activity in early Alzheimer disease

(2012) H. I. L. Jacobs et al.   NEUROLOGY

A Single Bout of Exercise Improves Motor Memory

(2012) Marc Roig et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Evolutionary entropy predicts the outcome of selection: Competition for resources that vary in abundance and diversity

(2012) Lloyd Demetrius et al.   THEORETICAL POPULATION BIOLOGY

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

(2011) Russell H. Swerdlow   ANTIOXIDANTS & REDOX SIGNALING

Insights into Mitochondrial Dysfunction: Aging, Amyloid-β, and Tau–A Deleterious Trio

(2011) Karen Schmitt et al.   ANTIOXIDANTS & REDOX SIGNALING

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Effect of Intranasal Insulin on Cognitive Function: A Systematic Review

(2011) Elad Shemesh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Somatic mutations in aging, cancer and neurodegeneration

(2011) Scott R. Kennedy et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death

(2011) Jaume Folch et al.   NEUROTOXICITY RESEARCH

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

(2011) Jordan T. Newington et al.   PLoS One

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

Physical Activity and Incident Cognitive Impairment in Elderly Persons

(2010) Thorleif Etgen   ARCHIVES OF INTERNAL MEDICINE

Physical Exercise, Aging, and Mild Cognitive Impairment

(2010) Yonas E. Geda et al.   ARCHIVES OF NEUROLOGY

Effects of Aerobic Exercise on Mild Cognitive Impairment

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

Activated astrocytes: a therapeutic target in Alzheimer’s disease?

(2009) Stacey Fuller et al.   Expert Review of Neurotherapeutics

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease

(2009) R. L. Buckner et al.   JOURNAL OF NEUROSCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Role of the Neuropathology of Alzheimer Disease in Dementia in the Oldest-Old

(2008) Vahram Haroutunian et al.   ARCHIVES OF NEUROLOGY

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

(2008) Adam S. Fleisher et al.   ARCHIVES OF NEUROLOGY

Hypometabolism as a therapeutic target in Alzheimer's disease

(2008) Lauren C Costantini et al.   BMC NEUROSCIENCE

The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

(2008) Bradford C. Dickerson et al.   CEREBRAL CORTEX

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

(2008) Sanjay W. Pimplikar   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin

(2008) Christian Benedict et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Pathophysiology of Neuronal Energy Crisis in Alzheimer’s Disease

(2008) Jack C. de la Torre   Neurodegenerative Diseases

The cortical signature of prodromal AD: Regional thinning predicts mild AD dementia

(2008) A. Bakkour et al.   NEUROLOGY