Synthesis, molecular modelling study of the methaqualone analogues as anti-convulsant agent with improved cognition activity and minimized neurotoxicity

Novel thiomorpholine tethered isatin hydrazones as potential inhibitors of resistant Mycobacterium tuberculosis

(2021) Sivanandhan Karunanidhi et al.   BIOORGANIC CHEMISTRY

Novel, selective acrylamide linked quinazolines for the treatment of double mutant EGFR-L858R/T790M Non-Small-Cell lung cancer (NSCLC)

(2021) Rahul Pawara et al.   BIOORGANIC CHEMISTRY

Quinazoline: An update on current status against convulsions

(2021) Rameshwar S. Cheke et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis, characterization, molecular docking and computational studies of 3-phenyl-2-thioxoimidazolidin-4-one derivatives

(2021) U. Vanitha et al.   JOURNAL OF MOLECULAR STRUCTURE

In silico search of triple mutant T790M/C797S allosteric inhibitors to conquer acquired resistance problem in non-small cell lung cancer (NSCLC): a combined approach of structure-based virtual screening and molecular dynamics simulation

(2020) Harun M. Patel et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

BREED based de novo hybridization approach: generating novel T790M/C797S-EGFR tyrosine kinase inhibitors to overcome the problem of mutation and resistance in non small cell lung cancer (NSCLC)

(2020) Harun M. Patel et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Recent advancement in the discovery and development of anti-epileptic biomolecules: An insight into structure activity relationship and Docking

(2020) Mukund Jha et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Revisiting the role of neurotransmitters in epilepsy: An updated review

(2020) Enes Akyuz et al.   LIFE SCIENCES

In search of selective 11β-HSD type 1 inhibitors without nephrotoxicity: An approach to resolve the metabolic syndrome by virtual based screening

(2018) Harun Patel et al.   Arabian Journal of Chemistry

Resolving the Mystery of Ring Opening in the Synthesis of benzo[d][1,3]oxazin-4-one and quinazolin-4(3H)-one

(2018) Harun Patel et al.   LETTERS IN ORGANIC CHEMISTRY

Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor

(2017) Mohamed Zayed et al.   MOLECULES

Theoretical studies on benzimidazole and imidazo[1,2-a]pyridine derivatives as Polo-like kinase 1 (Plk1) inhibitors: Pharmacophore modeling, atom-based 3D-QSAR and molecular docking approach

(2017) Rajasekhar Chekkara et al.   Journal of Saudi Chemical Society

Topiramate in Migraine Prevention: A 2016 Perspective

(2016) Stephen D. Silberstein   HEADACHE

Anti-convulsant potential of quinazolinones

(2016) Harun M. Patel et al.   RSC Advances

Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet

(2016) Michael A. Rogawski et al.   Cold Spring Harbor Perspectives in Medicine

Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinone

(2015) Huda S.A. Al-Salem et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Profiling the interaction mechanism of indole-based derivatives targeting the HIV-1 gp120 receptor

(2015) Jinghui Wang et al.   RSC Advances

Quantitative structure–activity relationship (QSAR) studies as strategic approach in drug discovery

(2014) Harun M. Patel et al.   MEDICINAL CHEMISTRY RESEARCH

Jaguar: A high-performance quantum chemistry software program with strengths in life and materials sciences

(2013) Art D. Bochevarov et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Pharmacophore and 3D-QSAR Characterization of 6-Arylquinazolin-4-amines as Cdc2-like Kinase 4 (Clk4) and Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A (Dyrk1A) Inhibitors

(2013) Yongmei Pan et al.   Journal of Chemical Information and Modeling

Design, synthesis, and biological evaluation studies of novel quinazolinone derivatives as anticonvulsant agents

(2013) Mohamed F. Zayed et al.   MEDICINAL CHEMISTRY RESEARCH

Some Novel Anticonvulsant Agents Derived from Phthalazinedione

(2012) M. Zayed et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives

(2012) Govindaraj Saravanan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of novel 7-aminoquinazoline derivatives: Antitumor and anticonvulsant activities

(2012) Adel S. El-Azab et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quinazolino–benzothiazoles: Fused pharmacophores as anticonvulsant agents

(2012) Vinod G. Ugale et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted-4(3H)-quinazoline derivatives

(2011) Adel S. El-Azab et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and potential 6 Hz psychomotor seizure test activity of some novel 2-(substituted)-3-{[substituted]amino}quinazolin-4(3H)-one

(2011) Praveen Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore filtering and 3D-QSAR in the discovery of new JAK2 inhibitors

(2011) Kh. Dhanachandra Singh et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Synthesis, method optimization, anticancer activity of 2,3,7-trisubstituted Quinazoline derivatives and targeting EGFR-tyrosine kinase by rational approach

(2011) Malleshappa N. Noolvi et al.   Arabian Journal of Chemistry

Antiepileptic drug therapy the story so far

(2010) Martin J. Brodie   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea

(2009) Sushil K. Kashaw et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cognitive Effects of Antiepileptic Drugs

(2008) Sung-Pa Park et al.   Journal of Clinical Neurology

Pharmacophore mapping of a series of pyrrolopyrimidines, indolopyrimidines and their congeners as multidrug-resistance-associated protein (MRP1) modulators

(2008) Nilesh R. Tawari et al.   JOURNAL OF MOLECULAR MODELING

CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones

(2007) Varsha Jatav et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY