Quinazoline: An update on current status against convulsions

Epilepsy is one of the most frequent chronic neurological disorder extremely threatening the life and good health. More than 70 million individuals suffering from epilepsy worldwide and it required longterm therapy. Many epileptic patients not fully satisfied with currently available treatment likewise, frequent drugs have shown a lack of efficacy, side effects, and drug interaction. Therefore, the search for antiepileptics with greater selectivity and lesser toxicity continues to be the focus and task in medicinal chemistry. Quinazoline represents a distinct class of biologically active nitrogen heterocyclic nucleus with great anticonvulsants potential. In the past few years, persistent medicinal chemistry effort s have developed diverse structurally functionalized potential quinazoline derivatives for anticonvulsant potential. This work report covers most current effort s t aken in the design, development, and anticonvulsant efficacy of quinazoline analogs from 2015 to 2020. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

Epilepsy is a common neurological disorder that requires long-term treatment. Current medications often have limited efficacy, side effects, and drug interactions, making the search for safer and more effective antiepileptic drugs a priority in medicinal chemistry.