Novel RNase H Inhibitors Blocking RNA-directed Strand Displacement DNA Synthesis by HIV-1 Reverse Transcriptase

Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction

(2021) Mar Álvarez et al.   Viruses-Basel

Small-molecule Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H function: Challenges and Recent Developments.

(2021) Valentina Noemi Madia et al.   CURRENT MEDICINAL CHEMISTRY

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

(2021) Antonella Messore et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors

(2021) Dongwei Kang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Defective strand-displacement DNA synthesis due to accumulation of thymidine analogue resistance mutations in HIV-2 reverse transcriptase

(2020) Samara Martín-Alonso et al.   ACS Infectious Diseases

DNA Strand Displacement Reaction: A Powerful Tool for Discriminating Single Nucleotide Variants

(2020) Weiyang Tang et al.   Topics in Current Chemistry

Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance

(2020) Francesc Xavier RUIZ et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Reverse Transcriptase: From Transcriptomics to Genome Editing

(2020) Samara Martín-Alonso et al.   TRENDS IN BIOTECHNOLOGY

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C

(2020) Ping Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Testing of library preparation methods for transcriptome sequencing of real life glioblastoma and brain tissue specimens: A comparative study with special focus on long non-coding RNAs

(2019) Marek Vecera et al.   PLoS One

Principles and Applications of Nucleic Acid Strand Displacement Reactions

(2019) Friedrich C. Simmel et al.   CHEMICAL REVIEWS

An emergent understanding of strand displacement in RNA biology

(2019) Fan Hong et al.   JOURNAL OF STRUCTURAL BIOLOGY

Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus

(2019) Enzo Tramontano et al.   ANTIVIRAL RESEARCH

Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase

(2019) Ping Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges

(2018) Xueshun Wang et al.   CURRENT MEDICINAL CHEMISTRY

5-Hydroxypyrido[2,3- b ]pyrazin-6(5 H )-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase

(2018) Lin Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Template-primer binding affinity and RNase H cleavage specificity contribute to the strand transfer efficiency of HIV-1 reverse transcriptase

(2018) Joanna Luczkowiak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid

(2018) Lan Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, Synthesis and Biological Evaluation of Novel Galloyl Derivatives as HIV-1 RNase H Inhibitors

(2018) Ping Gao et al.   Chemical Biology & Drug Design

Effective design principles for leakless strand displacement systems

(2018) Boya Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H

(2017) Jayakanth Kankanala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comparative Analysis of Single-Cell RNA Sequencing Methods

(2017) Christoph Ziegenhain et al.   MOLECULAR CELL

Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase

(2017) Omri Malik et al.   NUCLEIC ACIDS RESEARCH

Viral reverse transcriptases

(2017) Luis Menéndez-Arias et al.   VIRUS RESEARCH

HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently

(2016) An Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

(2016) Angela Corona et al.   PLoS One

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis

(2015) Gilberto Betancor et al.   NUCLEIC ACIDS RESEARCH

Inhibitors of Nucleotidyltransferase Superfamily Enzymes Suppress Herpes Simplex Virus Replication

(2014) John E. Tavis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Library preparation methods for next-generation sequencing: Tone down the bias

(2014) Erwin L. van Dijk et al.   EXPERIMENTAL CELL RESEARCH

Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs

(2014) Daniel M. Himmel et al.   JOURNAL OF MOLECULAR BIOLOGY

β-Thujaplicinol inhibits hepatitis B virus replication by blocking the viral ribonuclease H activity

(2013) Yuan Hu et al.   ANTIVIRAL RESEARCH

Major Groove Binding Track Residues of the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Enhance cDNA Synthesis at High Temperatures

(2013) Tania Matamoros et al.   BIOCHEMISTRY

Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis

(2013) Mar Álvarez et al.   NUCLEIC ACIDS RESEARCH

The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus

(2011) Yue-Lei Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A376S in the Connection Subdomain of HIV-1 Reverse Transcriptase Confers Increased Risk of Virological Failure to Nevirapine Therapy

(2011) Roger Paredes et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 Reverse Transcriptase Dissociates during Strand Transfer

(2011) John M. Muchiri et al.   JOURNAL OF MOLECULAR BIOLOGY

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

Mechanisms Involved in the Selection of HIV-1 Reverse Transcriptase Thumb Subdomain Polymorphisms Associated with Nucleoside Analogue Therapy Failure

(2010) G. Betancor et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Thymidine Analogue Resistance Suppression by V75I of HIV-1 Reverse Transcriptase

(2009) Tania Matamoros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Thermostability and Fidelity of DNA Synthesis of Wild-Type and Mutant HIV-1 Group O Reverse Transcriptases

(2009) Mar Álvarez et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

(2009) Greg L. Beilhartz et al.   JOURNAL OF MOLECULAR BIOLOGY

Single-Molecule Study of DNA Polymerization Activity of HIV-1 Reverse Transcriptase on DNA Templates

(2009) Sangjin Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Murine leukemia virus reverse transcriptase: Structural comparison with HIV-1 reverse transcriptase

(2008) Marie L. Coté et al.   VIRUS RESEARCH

Strand transfer events during HIV-1 reverse transcription

(2008) Vandana Purohit Basu et al.   VIRUS RESEARCH