Genetics of Alzheimer’s disease: an East Asian perspective

Challenge accepted: uncovering the role of rare genetic variants in Alzheimer’s disease

(2022) Marzieh Khani et al.   Molecular Neurodegeneration

Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability

(2021) Taimoor I. Sheikh et al.   Translational Psychiatry

Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk

(2021) Daichi Shigemizu et al.   Translational Psychiatry

Novel Alzheimer’s disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers

(2021) Jong-Ho Park et al.   Translational Psychiatry

Potential Novel Genes for Late-Onset Alzheimer’s Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study

(2021) Sarang Kang et al.   JOURNAL OF ALZHEIMERS DISEASE

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

(2021) Douglas P. Wightman et al.   NATURE GENETICS

A functional variant of SHARPIN confers increased risk of late-onset Alzheimer’s disease

(2021) Yuya Asanomi et al.   JOURNAL OF HUMAN GENETICS

APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia

(2021) Chia-Chen Liu et al.   Science Translational Medicine

The multiplex model of the genetics of Alzheimer’s disease

(2020) Rebecca Sims et al.   NATURE NEUROSCIENCE

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

(2020) Eric M. Reiman et al.   Nature Communications

Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

(2020) Qian Zhang et al.   Nature Communications

A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward

(2019) Michaël E. Belloy et al.   NEURON

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

(2019) Yuya Asanomi et al.   MOLECULAR MEDICINE

Association between Apolipoprotein E Gene Polymorphism and Alzheimer's Disease in an Iranian Population: A Meta-Analysis

(2019) Morteza Abyadeh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer’s Disease Risk in a Multiracial Sample

(2019) Kyu Choi et al.   Journal of Clinical Medicine

An Alzheimer’s-disease-protective APOE mutation

(2019) Kelly A. Zalocusky et al.   NATURE MEDICINE

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

Genetics of Alzheimer’s disease: where we are, and where we are going

(2019) Céline Bellenguez et al.   CURRENT OPINION IN NEUROBIOLOGY

Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis

(2018) Xiaopu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations

(2018) Yuchen Wang et al.   HEREDITAS

Lack of Genetic Association Between TREM2 and Late-Onset Alzheimer's Disease in a Japanese Population

(2018) Akinori Miyashita et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer’s disease

(2017) Luke W. Bonham et al.   NEUROCASE

The fine-scale genetic structure and evolution of the Japanese population

(2017) Fumihiko Takeuchi et al.   PLoS One

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

(2016) Elise Cuyvers et al.   LANCET NEUROLOGY

Progesterone exerts neuroprotective effects and improves long-term neurologic outcome after intracerebral hemorrhage in middle-aged mice

(2016) Chao Jiang et al.   NEUROBIOLOGY OF AGING

A genome-wide association study of late-onset Alzheimer’s disease in a Japanese population

(2015) Atsushi Hirano et al.   PSYCHIATRIC GENETICS

Association of Apolipoprotein E Genetic Variation in Alzheimer’s Disease in Indian Population

(2014) Rachna Agarwal et al.   American Journal of Alzheimers Disease and Other Dementias

ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer’s disease

(2014) Christopher W Medway et al.   Molecular Neurodegeneration

Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China

(2014) Bin Jiao et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E gene polymorphism and Alzheimer's disease in Chinese population: a meta-analysis

(2014) Mengying Liu et al.   Scientific Reports

Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases

(2013) Simon Kang Seng Ting et al.   NEUROBIOLOGY OF AGING

Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals

(2013) Yao-Wen Liu et al.   NEUROBIOLOGY OF AGING

Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals

(2013) Jin-Tai Yu et al.   NEUROBIOLOGY OF AGING

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

(2013) Akinori Miyashita et al.   PLoS One

Alzheimer’s Disease: Analyzing the Missing Heritability

(2013) Perry G. Ridge et al.   PLoS One

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease

(2011) Christiane Reitz   ARCHIVES OF NEUROLOGY

Genetic Structure of the Han Chinese Population Revealed by Genome-wide SNP Variation

(2009) Jieming Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS