CDK16 promotes the progression and metastasis of triple-negative breast cancer by phosphorylating PRC1

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups

(2019) Oscar M. Rueda et al.   NATURE

Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex

(2019) Sara Hernández-Ortega et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

(2019) Victor Quereda et al.   CANCER CELL

Imaging of Tie2 with a Fluorescently Labeled Small Molecule Affinity Ligand

(2019) Peter David Koch et al.   ACS Chemical Biology

Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma

(2018) Fanglong Wu et al.   Cell Death & Disease

Reducing protein regulator of cytokinesis 1 as a prospective therapy for hepatocellular carcinoma

(2018) Xinran Liu et al.   Cell Death & Disease

Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell

(2018) Yibing Si et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway

(2017) Ping Zhan et al.   Molecular Cancer

The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2 Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors

(2017) Allison S. Harney et al.   MOLECULAR CANCER THERAPEUTICS

Mechanisms of therapeutic CDK4/6 inhibition in breast cancer

(2017) Susan Combs Scott et al.   SEMINARS IN ONCOLOGY

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer

(2016) M. L. Telli et al.   CLINICAL CANCER RESEARCH

The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway

(2016) Jianxiang Chen et al.   GUT

Cyclin-Dependent Kinase 14 Promotes Cell Proliferation, Migration and Invasion in Ovarian Cancer by Inhibiting Wnt Signaling Pathway

(2016) Jun Ou-Yang et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Targeting the RB-E2F pathway in breast cancer

(2016) J Johnson et al.   ONCOGENE

RNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growth

(2016) Feng Yan et al.   ONCOLOGY REPORTS

Cyclin Y regulates the proliferation, migration, and invasion of ovarian cancer cells via Wnt signaling pathway

(2016) Haiyuan Liu et al.   TUMOR BIOLOGY

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells

(2016) Liyong Zeng et al.   PLoS Genetics

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

(2015) Yubao Wang et al.   CELL

Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion

(2014) Kouhei Shimizu et al.   FEBS LETTERS

Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: American Society of Clinical Oncology Clinical Practice Guideline

(2014) Naren Ramakrishna et al.   JOURNAL OF CLINICAL ONCOLOGY

Adjuvant Endocrine Therapy for Women With Hormone Receptor–Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Focused Update

(2014) Harold J. Burstein et al.   JOURNAL OF CLINICAL ONCOLOGY

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

Orphan kinases turn eccentric

(2012) Petra Mikolcevic et al.   CELL CYCLE

Dissecting the Heterogeneity of Triple-Negative Breast Cancer

(2012) Otto Metzger-Filho et al.   JOURNAL OF CLINICAL ONCOLOGY

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011

(2011) A. Goldhirsch et al.   ANNALS OF ONCOLOGY

The ABL Switch Control Inhibitor DCC-2036 Is Active against the Chronic Myeloid Leukemia Mutant BCR-ABLT315I and Exhibits a Narrow Resistance Profile

(2011) C. A. Eide et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cell Cycle Protein Cyclin Y Is Associated With Human Non–Small-Cell Lung Cancer Proliferation and Tumorigenesis

(2011) Wentao Yue et al.   Clinical Lung Cancer

Cyclin-Dependent Kinase 16/PCTAIRE Kinase 1 Is Activated by Cyclin Y and Is Essential for Spermatogenesis

(2011) P. Mikolcevic et al.   MOLECULAR AND CELLULAR BIOLOGY

Lentivirus-Mediated Knockdown of Cyclin Y (CCNY) Inhibits Glioma Cell Proliferation

(2010) YongGang Xu et al.   ONCOLOGY RESEARCH

Cell Cycle Control of Wnt Receptor Activation

(2009) Gary Davidson et al.   DEVELOPMENTAL CELL

Cyclin-dependent kinases: a family portrait

(2009) Marcos Malumbres et al.   NATURE CELL BIOLOGY