Targeting the RB-E2F pathway in breast cancer

 -Arrestin-1 Mediates Nicotine-Induced Metastasis through E2F1 Target Genes That Modulate Epithelial-Mesenchymal Transition

(2015) S. Pillai et al.   CANCER RESEARCH

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

(2015) Richard S Finn et al.   LANCET ONCOLOGY

Redeployment of Myc and E2f1–3 drives Rb-deficient cell cycles

(2015) Huayang Liu et al.   NATURE CELL BIOLOGY

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors

(2014) Sadhna R. Vora et al.   CANCER CELL

Molecular Pathways: CDK4 Inhibitors for Cancer Therapy

(2014) M. A. Dickson   CLINICAL CANCER RESEARCH

The E2F Transcription Factors Regulate Tumor Development and Metastasis in a Mouse Model of Metastatic Breast Cancer

(2014) D. P. Hollern et al.   MOLECULAR AND CELLULAR BIOLOGY

REACTIN: Regulatory activity inference of transcription factors underlying human diseases with application to breast cancer

(2013) Mingzhu Zhu et al.   BMC GENOMICS

Cyclin-dependent kinase inhibitor therapy for hematologic malignancies

(2013) Prithviraj Bose et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer

(2013) A K Witkiewicz et al.   ONCOGENE

HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors

(2013) E R Andrechek   ONCOGENE

Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis

(2013) L Wu et al.   ONCOGENE

The retinoblastoma tumor suppressor and stem cell biology

(2012) J. Sage   GENES & DEVELOPMENT

Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer

(2012) Yoshimi Arima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

(2012) Anirudh Prahallad et al.   NATURE

Prediction and Genetic Demonstration of a Role for Activator E2Fs in Myc-Induced Tumors

(2011) K. Fujiwara et al.   CANCER RESEARCH

Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb-Raf-1 Interaction as a Novel Target for Metastatic Disease

(2011) J. L. Johnson et al.   CANCER RESEARCH

An Integrated Bioinformatics Approach Identifies Elevated Cyclin E2 Expression and E2F Activity as Distinct Features of Tamoxifen Resistant Breast Tumors

(2011) Lei Huang et al.   PLoS One

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

Small molecule regulators of Rb–E2F pathway as modulators of transcription

(2010) Sandeep Singh et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Deconstructing the molecular portraits of breast cancer

(2010) Aleix Prat et al.   Molecular Oncology

A pathway-based classification of human breast cancer

(2010) M. L. Gatza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene set-based module discovery in the breast cancer transcriptome

(2009) Atsushi Niida et al.   BMC BIOINFORMATICS

Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen

(2009) M. M. Fluck et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells

(2009) Jean-Leon Chong et al.   NATURE

Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells

(2008) Atsushi Niida et al.   BMC BIOINFORMATICS

Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer

(2008) Mads Thomassen et al.   BMC CANCER

Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen

(2008) Sherene Loi et al.   BMC GENOMICS

A Gene Expression Signature that Can Predict the Recurrence of Tamoxifen-Treated Primary Breast Cancer

(2008) M. Chanrion et al.   CLINICAL CANCER RESEARCH

CDK9 a Potential Target for Drug Development

(2008) Fernanda Canduri et al.   Medicinal Chemistry

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS