Real-time monitoring of antibody quality attributes for cell culture production processes in bioreactors via integration of an automated sampling technology with multi-dimensional liquid chromatography mass spectrometry

Online monitoring and control of upstream cell culture process using 1D and 2D‐LC with SegFlow interface

(2021) Letha Chemmalil et al.   BIOTECHNOLOGY AND BIOENGINEERING

Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification

(2021) Eun Ji Kim et al.   Pharmaceutics

Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MS

(2021) Julien Camperi et al.   TALANTA

Targeted Bottom-up Characterization of Recombinant Monoclonal Antibodies by Multidimensional LC/MS

(2020) Julien Camperi et al.   ANALYTICAL CHEMISTRY

N-glycans of complex glycosylated biopharmaceuticals and their impact on protein clearance

(2019) Fabian Higel et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development

(2019) Nagesh K. Tripathi et al.   Frontiers in Bioengineering and Biotechnology

Impact of cell culture media additives on IgG glycosylation produced in CHO cells

(2018) Janike Ehret et al.   BIOTECHNOLOGY AND BIOENGINEERING

Strategies to enhance productivity and modify product quality in therapeutic proteins

(2018) Devesh Radhakrishnan et al.   Current Opinion in Chemical Engineering

On-line prediction of the glucose concentration of CHO cell cultivations by NIR and Raman spectroscopy: Comparative scalability test with a shake flask model system

(2017) Bence Kozma et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

High-Throughput, Automated Protein A Purification Platform with Multiattribute LC–MS Analysis for Advanced Cell Culture Process Monitoring

(2016) Jia Dong et al.   ANALYTICAL CHEMISTRY

A framework for real-time glycosylation monitoring (RT-GM) in mammalian cell culture

(2015) Tharmala Tharmalingam et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

(2015) Brandon N. Berry et al.   BIOTECHNOLOGY PROGRESS

Development of at-line assay to monitor charge variants of MAbs during production

(2013) M. M. St. Amand et al.   BIOTECHNOLOGY PROGRESS

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

(2012) Jessica Whelan et al.   BIOTECHNOLOGY PROGRESS

Studying the drift of in line pH measurements in cell culture

(2011) V. Saucedo et al.   BIOTECHNOLOGY PROGRESS

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Roadmap for implementation of quality by design (QbD) for biotechnology products

(2009) Anurag S. Rathore   TRENDS IN BIOTECHNOLOGY