Combinatorial Inhibition of Myostatin and Activin A Improves Femoral Bone Properties in the G610C Mouse Model of Osteogenesis Imperfecta

Inhibition of myostatin prevents microgravity-induced loss of skeletal muscle mass and strength

(2020) Rosamund C. Smith et al.   PLoS One

The Evolution of the Nosology of Osteogenesis Imperfecta

(2020) Chetty Manogari et al.   CLINICAL GENETICS

Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight

(2020) Se-Jin Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Genetic and Pharmacologic Inhibition of Myostatin in a Murine Model of Osteogenesis Imperfecta

(2020) Catherine L Omosule et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle

(2020) Emma Rybalka et al.   Cells

Novel ActRIIB ligand trap increases muscle mass and improves bone geometry in a mouse model of severe osteogenesis imperfecta

(2019) Josephine T. Tauer et al.   BONE

Skeletal Response to Soluble Activin Receptor Type IIB in Mouse Models of Osteogenesis Imperfecta

(2018) Youngjae Jeong et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of a telescopic intramedullary rod for treating patients with osteogenesis imperfecta of the femur

(2018) D. L. Rosemberg et al.   Journal of Childrens Orthopaedics

Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication

(2017) Yiwen Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic phenotype in the mouse model of osteogenesis imperfecta

(2017) Iris Boraschi-Diaz et al.   JOURNAL OF ENDOCRINOLOGY

Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease

(2017) Toshifumi Sugatani et al.   KIDNEY INTERNATIONAL

Soluble activin receptor type IIB decoy receptor differentially impacts murine osteogenesis imperfecta muscle function

(2017) Youngjae Jeong et al.   MUSCLE & NERVE

Activin A more prominently regulates muscle mass in primates than does GDF8

(2017) Esther Latres et al.   Nature Communications

Osteogenesis imperfecta

(2017) Joan C. Marini et al.   Nature Reviews Disease Primers

Body Composition in Children and Adolescents with Osteogenesis Imperfecta

(2016) Telma Palomo et al.   JOURNAL OF PEDIATRICS

Osteogenesis imperfecta

(2016) Antonella Forlino et al.   LANCET

Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial

(2016) Craig Campbell et al.   MUSCLE & NERVE

The functional muscle–bone unit in patients with osteogenesis imperfecta type I

(2015) Louis-Nicolas Veilleux et al.   BONE

Proximal Migration of Femoral Telescopic Rod in Children With Osteogenesis Imperfecta

(2015) Kang Lee et al.   JOURNAL OF PEDIATRIC ORTHOPAEDICS

Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice

(2015) Berno Dankbar et al.   NATURE MEDICINE

Myostatin Regulates Energy Homeostasis in the Heart and Prevents Heart Failure

(2014) Nadine Biesemann et al.   CIRCULATION RESEARCH

Blockade of ActRIIB Signaling Triggers Muscle Fatigability and Metabolic Myopathy

(2014) Karima Relizani et al.   MOLECULAR THERAPY

TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease

(2014) Roberta Sartori et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A myostatin and activin decoy receptor enhances bone formation in mice

(2013) P. Bialek et al.   BONE

Increased Muscle Force Production and Bone Mineral Density in ActRIIB-Fc-Treated Mature Rodents

(2013) C.-S. Chiu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Activin A Suppresses Osteoblast Mineralization Capacity by Altering Extracellular Matrix (ECM) Composition and Impairing Matrix Vesicle (MV) Production

(2013) Rodrigo D. A. M. Alves et al.   MOLECULAR & CELLULAR PROTEOMICS

Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice

(2011) Sun Ju Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

New perspectives on osteogenesis imperfecta

(2011) Antonella Forlino et al.   Nature Reviews Endocrinology

A Soluble Activin Receptor Type IIB Prevents the Effects of Androgen Deprivation on Body Composition and Bone Health

(2010) Alan Koncarevic et al.   ENDOCRINOLOGY

Hindlimb skeletal muscle function in myostatin-deficient mice

(2010) Bettina A. Gentry et al.   MUSCLE & NERVE

Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Normal and Dystrophic Mice

(2010) Kevin J. Morine et al.   PLoS One

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Estrogen receptor-α and -β and aromatase knockout effects on lower limb muscle mass and contractile function in female mice

(2009) Marybeth Brown et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model

(2009) Ethan Daley et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

Osteogenesis imperfecta

(2008) Francis H. Glorieux   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators

(2008) Tatyana A. Souza et al.   MOLECULAR ENDOCRINOLOGY

A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

(2008) R. S. Pearsall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA