Inhibition of myostatin prevents microgravity-induced loss of skeletal muscle mass and strength

Behavior of mice aboard the International Space Station

(2019) April E. Ronca et al.   Scientific Reports

The Effects of Muscle Strength Responsiveness to Periodized Resistance Training on Resistin, Leptin, and Cytokine in Elderly Postmenopausal Women

(2018) Jonato Prestes et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Effects of spaceflight on the muscles of the murine shoulder

(2017) Hua Shen et al.   FASEB JOURNAL

Cortical and Trabecular Bone Microstructure Did Not Recover at Weight-Bearing Skeletal Sites and Progressively Deteriorated at Non-Weight-Bearing Sites During the Year Following International Space Station Missions

(2017) Laurence Vico et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study

(2017) Daniel Rooks et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Gene Expression Profiling in Slow-Type Calf Soleus Muscle of 30 Days Space-Flown Mice

(2017) Guido Gambara et al.   PLoS One

Effect of bimagrumab on thigh muscle volume and composition in men with casting-induced atrophy

(2017) Daniel S. Rooks et al.   Journal of Cachexia Sarcopenia and Muscle

One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons

(2017) Maude Gerbaix et al.   Scientific Reports

Development of new experimental platform ‘MARS’—Multiple Artificial-gravity Research System—to elucidate the impacts of micro/partial gravity on mice

(2017) Dai Shiba et al.   Scientific Reports

Elevated levels of Interleukin (IL)-33 induce bone pathology but absence of IL-33 does not negatively impact normal bone homeostasis

(2016) Angela J. Okragly et al.   CYTOKINE

Lumbar Spine Paraspinal Muscle and Intervertebral Disc Height Changes in Astronauts After Long-Duration Spaceflight on the International Space Station

(2016) Douglas G. Chang et al.   SPINE

Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days)

(2016) Eric L Moyer et al.   NPJ Microgravity

Osteoprotegerin is an effective countermeasure for spaceflight-induced bone loss in mice

(2015) Shane A. Lloyd et al.   BONE

Masticatory muscles of mouse do not undergo atrophy in space

(2015) Anastassios Philippou et al.   FASEB JOURNAL

Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments

(2015) Britta Berg-Johansen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting

(2015) R. C. Smith et al.   MOLECULAR CANCER THERAPEUTICS

Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial

(2015) Clemens Becker et al.   Lancet Diabetes & Endocrinology

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

(2015) Esther Latres et al.   Skeletal Muscle

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

(2014) Sue C. Bodine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Muscle Strength and Physical Performance as Predictors of Mortality, Hospitalization, and Disability in the Oldest Old

(2014) Delphine Legrand et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases

(2014) Rita Rastogi Kalyani et al.   Lancet Diabetes & Endocrinology

A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength

(2013) Phonepasong Arounleut et al.   EXPERIMENTAL GERONTOLOGY

The past, present, and future of National Aeronautics and Space Administration spaceflight diet in support of microgravity rodent experiments

(2013) Gwo-Shing Sun et al.   NUTRITION

Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders

(2013) Rosamund C. Smith et al.   Current Opinion in Supportive and Palliative Care

Measuring the Strength of Mice

(2013) Robert M.J. Deacon   Jove-Journal of Visualized Experiments

Circulating αKlotho influences phosphate handling by controlling FGF23 production

(2012) Rosamund C. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Longitudinal characterization of functional, morphologic, and biochemical adaptations in mouse skeletal muscle with hindlimb suspension

(2012) Andrea M. Hanson et al.   MUSCLE & NERVE

Bone Turnover in Wild Type and Pleiotrophin-Transgenic Mice Housed for Three Months in the International Space Station (ISS)

(2012) Sara Tavella et al.   PLoS One

Adaptation of Mouse Skeletal Muscle to Long-Term Microgravity in the MDS Mission

(2012) Dorianna Sandonà et al.   PLoS One

Age-Related Changes in Bone Structure and Strength in Female and Male BALB/c Mice

(2010) Mark D. Willinghamm et al.   CALCIFIED TISSUE INTERNATIONAL

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres

(2010) R. H. Fitts et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise in space: human skeletal muscle after 6 months aboard the International Space Station

(2009) Scott Trappe et al.   JOURNAL OF APPLIED PHYSIOLOGY

Bone microstructure and its associated genetic variability in 12 inbred mouse strains: μCT study and in silico genome scan

(2007) Ilya Sabsovich et al.   BONE