Increased Muscle Force Production and Bone Mineral Density in ActRIIB-Fc-Treated Mature Rodents

Automated rodent in situ muscle contraction assay and myofiber organization analysis in sarcopenia animal models

(2012) H. Weber et al.   JOURNAL OF APPLIED PHYSIOLOGY

Testosterone Improves the Regeneration of Old and Young Mouse Skeletal Muscle

(2012) C. Serra et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

(2010) Sutada Lotinun et al.   BONE

A Soluble Activin Receptor Type IIB Prevents the Effects of Androgen Deprivation on Body Composition and Bone Health

(2010) Alan Koncarevic et al.   ENDOCRINOLOGY

Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function

(2010) Kate T. Murphy et al.   FASEB JOURNAL

Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type

(2010) Samuel M. Cadena et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, and Quality of Life in Intermediate-Frail and Frail Elderly Men: A Randomized, Double-Blind, Placebo-Controlled Study

(2010) Upendram Srinivas-Shankar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis

(2010) M. Mercè Fernández-Balsells et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis

(2010) Sebastio Perrini et al.   JOURNAL OF ENDOCRINOLOGY

IgG2m4, an engineered antibody isotype with reduced Fc function

(2010) Zhiqiang An et al.   mAbs

Adverse Events Associated with Testosterone Administration

(2010) Shehzad Basaria et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of myostatin deletion in aging mice

(2009) Michael R. Morissette et al.   AGING CELL

Myostatin regulates fiber-type composition of skeletal muscle by regulating MEF2 and MyoD gene expression

(2009) Alex Hennebry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Testosterone Supplementation Reverses Sarcopenia in Aging through Regulation of Myostatin, c-Jun NH2-Terminal Kinase, Notch, and Akt Signaling Pathways

(2009) Ekaterina L. Kovacheva et al.   ENDOCRINOLOGY

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

(2009) I Akpan et al.   INTERNATIONAL JOURNAL OF OBESITY

Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men

(2009) Fred R. Sattler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Myostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume

(2008) Ethan Kellum et al.   BONE

Myostatin as a therapeutic target for musculoskeletal disease

(2008) L. Bradley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signal Transduction Pathway through Activin Receptors as a Therapeutic Target of Musculoskeletal Diseases and Cancer

(2008) Kunihiro TSUCHIDA et al.   ENDOCRINE JOURNAL

Double-sigmoid model for fitting fatigue profiles in mouse fast- and slow-twitch muscle

(2008) S. P. Cairns et al.   EXPERIMENTAL PHYSIOLOGY

Update on emerging drugs for sarcopenia – age-related muscle wasting

(2008) Gordon S Lynch   EXPERT OPINION ON EMERGING DRUGS

Myostatin preferentially down-regulates the expression of fast 2x myosin heavy chain in cattle

(2008) Shinichiro HAYASHI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

(2008) R. S. Pearsall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH