Selective PPARδ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway

Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ

(2021) Lorena Mazuecos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis

(2021) Andreas E. Kremer et al.   LIVER INTERNATIONAL

JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma

(2020) Elisa Manieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice

(2020) Huikuan Chu et al.   Translational Research

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

(2019) Meredith A Sommars et al.   eLife

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

(2019) Hsiao-Yen Ma et al.   JOURNAL OF HEPATOLOGY

FGF21 acts as a negative regulator of bile acid synthesis

(2018) Michelle M Chen et al.   JOURNAL OF ENDOCRINOLOGY

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis

(2018) Katharina Brandl et al.   JOURNAL OF HEPATOLOGY

Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action

(2017) Jun Zhang et al.   EBioMedicine

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency

(2016) Mohammad Zarei et al.   DIABETES

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

(2015) Brian C. Ferslew et al.   DIGESTIVE DISEASES AND SCIENCES

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

(2012) Ana Luísa De Sousa-Coelho et al.   BIOCHEMICAL JOURNAL

Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands

(2012) R. Goetz et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: A pilot study

(2011) Jocelyn Trottier et al.   DIGESTIVE AND LIVER DISEASE

Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man

(2009) Constantinos Christodoulides et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

C-terminal Tail of FGF19 Determines Its Specificity toward Klotho Co-receptors

(2008) Xinle Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY