Investigating Causal Relations Between Circulating Metabolites and Alzheimer’s Disease: A Mendelian Randomization Study

Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer’s disease

(2021) Jodie Lord et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

(2020) Fiona A. Hagenbeek et al.   Nature Communications

Low-Density Lipoprotein Cholesterol and Alzheimer's Disease: A Systematic Review and Meta-Analysis

(2020) Zhike Zhou et al.   Frontiers in Aging Neuroscience

Circulating Glutamine and Alzheimer’s Disease: A Mendelian Randomization Study

(2020) Charleen D Adams   Clinical Interventions in Aging

Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study

(2020) Mei Cui et al.   Alzheimers & Dementia

Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

(2020) Olalla Sáiz-Vazquez et al.   Brain Sciences

High Density Lipoprotein‐related cholesterol metabolism in Alzheimer’s Disease

(2020) S. Pedrini et al.   JOURNAL OF NEUROCHEMISTRY

Prediction of Alzheimer’s disease with serum lipid levels in Asian individuals: A meta-analysis

(2019) Yufei Wu et al.   BIOMARKERS

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Low-Density Lipoprotein Particle Size Subfractions and Cerebral Amyloidosis

(2019) Sung Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

Apolipoprotein B as a New Link Between Cholesterol and Alzheimer Disease

(2019) Makoto Ishii   JAMA Neurology

Association of Early-Onset Alzheimer Disease With Elevated Low-density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB

(2019) Thomas S. Wingo et al.   JAMA Neurology

Variability in Total Cholesterol Concentration Is Associated With the Risk of Dementia: A Nationwide Population-Based Cohort Study

(2019) Hye Soo Chung et al.   Frontiers in Neurology

GlycA, a novel pro‐inflammatory glycoprotein biomarker is associated with mortality: results from the PREVEND study and meta‐analysis

(2019) E. G. Gruppen et al.   JOURNAL OF INTERNAL MEDICINE

Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS

(2019) Yuhei Takado et al.   Nutrients

GlycA, a composite low‐grade inflammatory marker, predicts mortality: prime time for utilization?

(2019) D. A. Duprez et al.   JOURNAL OF INTERNAL MEDICINE

Elevated serum TC and LDL-C levels in Alzheimer’s disease and mild cognitive impairment: A meta-analysis study

(2019) Yang Liu et al.   BRAIN RESEARCH

Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis

(2019) Zhiguang Huo et al.   NEUROBIOLOGY OF AGING

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

(2018) Sven J. van der Lee et al.   Alzheimers & Dementia

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

(2018) Vijay R. Varma et al.   PLOS MEDICINE

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

GWAS on family history of Alzheimer’s disease

(2018) Riccardo E. Marioni et al.   Translational Psychiatry

Application of Metabolomics in Alzheimer’s Disease

(2018) Jordan Maximillian Wilkins et al.   Frontiers in Neurology

Lifetime cognition and late midlife blood metabolites: findings from a British birth cohort

(2018) Petroula Proitsi et al.   Translational Psychiatry

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian Randomization

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation

(2017) Myungjin Jo et al.   JOURNAL OF NEUROSCIENCE

Case–control association mapping by proxy using family history of disease

(2017) Jimmy Z Liu et al.   NATURE GENETICS

Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS

(2017) Niels Westergaard et al.   NEUROCHEMICAL RESEARCH

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases

(2017) Ekaterina A. Ivanova et al.   Oxidative Medicine and Cellular Longevity

A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization

(2017) Jack Bowden et al.   STATISTICS IN MEDICINE

Low LDL cholesterol,PCSK9andHMGCRgenetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study

(2017) Marianne Benn et al.   BMJ-British Medical Journal

Low LDL cholesterol,PCSK9andHMGCRgenetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study

(2017) Marianne Benn et al.   BMJ-British Medical Journal

Apolipoproteins and HDL cholesterol do not associate with the risk of future dementia and Alzheimer’s disease: the National Finnish population study (FINRISK)

(2016) Juho Tynkkynen et al.   AGE

Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment

(2016) Dandan Huang et al.   EUROPEAN RADIOLOGY

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Commentary: Two-sample Mendelian randomization: opportunities and challenges

(2016) Debbie A Lawlor   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Alterations in Cerebral Cortical Glucose and Glutamine Metabolism Precedes Amyloid Plaques in the APPswe/PSEN1dE9 Mouse Model of Alzheimer’s Disease

(2016) Jens V. Andersen et al.   NEUROCHEMICAL RESEARCH

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

(2016) Johannes Kettunen et al.   Nature Communications

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Orosomucoid, an acute response protein with multiple modulating activities

(2015) Zhumin Luo et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

(2015) Søren D. Østergaard et al.   PLOS MEDICINE

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome

(2014) S. Burgess   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice

(2013) Tina Löffler et al.   NEUROBIOLOGY OF AGING

Plasma Apolipoprotein Levels Are Associated with Cognitive Status and Decline in a Community Cohort of Older Individuals

(2012) Fei Song et al.   PLoS One

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

(2010) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-β

(2009) Ryusuke Takechi et al.   BRITISH JOURNAL OF NUTRITION

Three-dimensional colocalization analysis of plasma-derived apolipoprotein B with amyloid plaques in APP/PS1 transgenic mice

(2009) Ryusuke Takechi et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Functional connectivity of default mode network components: Correlation, anticorrelation, and causality

(2008) Lucina Q. Uddin et al.   HUMAN BRAIN MAPPING