Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression

Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression

(2021) Siamak MahmoudianDehkordi et al.   Translational Psychiatry

A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression

(2021) Helena U. Zacharias et al.   MOLECULAR PSYCHIATRY

Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

(2021) Yuri Milaneschi et al.   MOLECULAR PSYCHIATRY

Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study

(2021) Benjamin I. Perry et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduced mitochondrial respiration in T cells of patients with major depressive disorder

(2021) Stefanie Gamradt et al.   iScience

Depression heterogeneity and its biological underpinnings: towards immuno-metabolic depression

(2020) Yuri Milaneschi et al.   BIOLOGICAL PSYCHIATRY

Depression profilers and immuno-metabolic dysregulation: Longitudinal results from the NESDA study

(2020) Femke Lamers et al.   BRAIN BEHAVIOR AND IMMUNITY

High-definition likelihood inference of genetic correlations across human complex traits

(2020) Zheng Ning et al.   NATURE GENETICS

Clinical manifestations and management of fatty acid oxidation disorders

(2020) J. Lawrence Merritt et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

A nationwide retrospective observational study of population newborn screening for medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency in the Netherlands

(2019) Emmalie A. Jager et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Commentary: Causal associations between inflammation, cardiometablic markers and schizophrenia: the known unknowns

(2019) Golam M Khandaker   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

(2019) Ke-qi Fan et al.   CELL

Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes

(2019) Ahmed T. Ahmed et al.   JOURNAL OF AFFECTIVE DISORDERS

Elevated Medium-Chain Acylcarnitines Are Associated With Gestational Diabetes Mellitus and Early Progression to Type 2 Diabetes and Induce Pancreatic β-Cell Dysfunction

(2018) Battsetseg Batchuluun et al.   DIABETES

Robust research needs many lines of evidence

(2018) Marcus R. Munafò et al.   NATURE

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Acetyl-l-carnitine deficiency in patients with major depressive disorder

(2018) Carla Nasca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects

(2018) Ruin Moaddel et al.   PSYCHOPHARMACOLOGY

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

(2017) Tao Long et al.   NATURE GENETICS

A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization

(2017) Jack Bowden et al.   STATISTICS IN MEDICINE

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Bias due to participant overlap in two-sample Mendelian randomization

(2016) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique

(2016) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant

(2016) T Lau et al.   MOLECULAR PSYCHIATRY

Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance

(2016) Benedetta Bigio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants

(2016) D M Rotroff et al.   Translational Psychiatry

Major depressive disorder

(2016) Christian Otte et al.   Nature Reviews Disease Primers

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

(2015) Gerwyn Morris et al.   BMC Medicine

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Mechanisms of stress in the brain

(2015) Bruce S McEwen et al.   NATURE NEUROSCIENCE

Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice

(2015) W. Wang et al.   NEUROSCIENCE

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress

(2015) Martin Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

(2015) Harmen H. M. Draisma et al.   Nature Communications

Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression

(2015) A Karabatsiakis et al.   Translational Psychiatry

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Long-Term Increased Carnitine Palmitoyltransferase 1A Expression in Ventromedial Hypotalamus Causes Hyperphagia and Alters the Hypothalamic Lipidomic Profile

(2014) Paula Mera et al.   PLoS One

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Mitochondrial respiration in blood platelets of depressive patients

(2013) Jana Hroudová et al.   MITOCHONDRION

Upregulation of mGlu2 Receptors via NF-κB p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine

(2013) Bruna Cuccurazzu et al.   NEUROPSYCHOPHARMACOLOGY

Mitochondria impact brain function and cognition

(2013) M. Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors

(2013) C. Nasca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional Association Between Depression and Metabolic Syndrome: A systematic review and meta-analysis of epidemiological studies

(2012) A. Pan et al.   DIABETES CARE

Cerebrospinal Fluid Metabolome in Mood Disorders-Remission State has a Unique Metabolic Profile

(2012) Rima Kaddurah-Daouk et al.   Scientific Reports

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

(2010) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Metabolomic Differences in Heart Failure Patients With and Without Major Depression

(2010) David C. Steffens et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Acylcarnitines: Role in brain

(2009) Lauren L. Jones et al.   PROGRESS IN LIPID RESEARCH