The Emerging Role of Cell Transdifferentiation in Skeletal Development and Diseases

SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

(2021) Abdul Haseeb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of vasculature and chondrocyte to osteoblast transdifferentiation in craniofacial synovial joints: Implications for osteoarthritis diagnosis and therapy

(2020) Angela Ruscitto et al.   FASEB JOURNAL

Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis

(2020) Anke J Roelofs et al.   ANNALS OF THE RHEUMATIC DISEASES

ScxLin cells directly form a subset of chondrocytes in temporomandibular joint that are sharply increased in Dmp1-null mice

(2020) Chi Ma et al.   BONE

Chondrocyte‐to‐osteoblast transformation in mandibular fracture repair

(2020) Sarah A. Wong et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts

(2020) Xin Qin et al.   PLoS Genetics

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture

(2019) Tingjun Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Persistent Sox9 expression in hypertrophic chondrocytes suppresses transdifferentiation into osteoblasts

(2019) Julian C. Lui et al.   BONE

Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate

(2019) Haraguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypophosphatemic rickets accelerate chondrogenesis and cell trans-differentiation from TMJ chondrocytes into bone cells via a sharp increase in β-catenin

(2019) Hui Li et al.   BONE

Osteoarthritis

(2019) Benjamin Abramoff et al.   MEDICAL CLINICS OF NORTH AMERICA

Single-cell RNA-seq analysis reveals the progression of human osteoarthritis

(2018) Quanbo Ji et al.   ANNALS OF THE RHEUMATIC DISEASES

Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells

(2018) Yan Jing et al.   International Journal of Biological Sciences

Diverse contribution of Col2a1 -expressing cells to the craniofacial skeletal cell lineages

(2017) N. Sakagami et al.   Orthodontics & Craniofacial Research

Rickets

(2017) Thomas O. Carpenter et al.   Nature Reviews Disease Primers

Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing

(2017) Kristen Howell et al.   Scientific Reports

Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system

(2017) Yuki Yoshimoto et al.   Scientific Reports

Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process

(2017) Yan Jing et al.   Scientific Reports

Epiphyseal bone formation occurs via thyroid hormone regulation of chondrocyte to osteoblast transdifferentiation

(2017) Patrick Aghajanian et al.   Scientific Reports

Thyroid hormone receptor-β1 signaling is critically involved in regulating secondary ossification via promoting transcription of the Ihh gene in the epiphysis

(2016) Weirong Xing et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration

(2016) Sandeep Paul et al.   DEVELOPMENT

β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis

(2016) Astrid Houben et al.   DEVELOPMENT

Dmp1 Null Mice Develop a Unique Osteoarthritis-like Phenotype

(2016) Qi Zhang et al.   International Journal of Biological Sciences

Roles of Chondrocytes in Endochondral Bone Formation and Fracture Repair

(2016) R.J. Hinton et al.   JOURNAL OF DENTAL RESEARCH

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon

(2016) Shailesh Agarwal et al.   STEM CELLS

Co-localization of Cell Lineage Markers and the Tomato Signal

(2016) Yan Jing et al.   Jove-Journal of Visualized Experiments

On the development of the patella

(2015) S. Eyal et al.   DEVELOPMENT

Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse

(2015) Joohyun Lim et al.   DEVELOPMENT

Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone

(2015) A. Takimoto et al.   DEVELOPMENT

Chondrocytes Directly Transform into Bone Cells in Mandibular Condyle Growth

(2015) Y. Jing et al.   JOURNAL OF DENTAL RESEARCH

Molecular regulation of tendon cell fate during development

(2015) Alice H. Huang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The role of hedgehog signalling in skeletal health and disease

(2015) Benjamin A. Alman   Nature Reviews Rheumatology

Tendon injury: from biology to tendon repair

(2015) Geoffroy Nourissat et al.   Nature Reviews Rheumatology

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

(2015) Xiaolin Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage

(2015) J. Park et al.   Biology Open

Osteogenic fate of hypertrophic chondrocytes

(2014) Guan Yang et al.   CELL RESEARCH

Epiphyseal Chondrocyte Secondary Ossification Centers Require Thyroid Hormone Activation of Indian Hedgehog and Osterix Signaling

(2014) Weirong Xing et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation

(2013) Svitlana Golovchenko et al.   BONE

Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia

(2013) Jian Q. Feng et al.   BONE

Tendon-bone attachment unit is formed modularly by a distinct pool of Scx - and Sox9 -positive progenitors

(2013) Einat Blitz et al.   DEVELOPMENT

Transdifferentiation of mesenchymal stem cells-derived adipogenic-differentiated cells into osteogenic- or chondrogenic-differentiated cells proceeds via dedifferentiation and have a correlation with cell cycle arresting and driving genes

(2013) Mujib Ullah et al.   DIFFERENTIATION

BMP Receptor 1A Determines the Cell Fate of the Postnatal Growth Plate

(2013) Junjun Jing et al.   International Journal of Biological Sciences

Stem Cell-Derived Endochondral Cartilage Stimulates Bone Healing by Tissue Transformation

(2013) Chelsea S Bahney et al.   JOURNAL OF BONE AND MINERAL RESEARCH

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis

(2013) Maricela Maldonado et al.   Biomed Research International

Physiopathology of intratendinous calcific deposition

(2012) Francesco Oliva et al.   BMC Medicine

Lineage Tracing

(2012) Kai Kretzschmar et al.   CELL

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

(2012) Lige Song et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

(2012) Debbie Y Dao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Human Dedifferentiated Adipocytes Show Similar Properties to Bone Marrow-Derived Mesenchymal Stem Cells

(2012) Antonella Poloni et al.   STEM CELLS

Roles of DMP1 Processing in Osteogenesis, Dentinogenesis and Chondrogenesis

(2011) Yao Sun et al.   CELLS TISSUES ORGANS

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

(2011) D. Ikegami et al.   DEVELOPMENT

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

(2011) B. Shu et al.   JOURNAL OF CELL SCIENCE

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

FGF23 in Skeletal Modeling and Remodeling

(2011) Yongbo Lu et al.   Current Osteoporosis Reports

Signaling networks in RUNX2-dependent bone development

(2010) Toshihisa Komori   JOURNAL OF CELLULAR BIOCHEMISTRY

Transient Activation of Wnt/β-Catenin Signaling Induces Abnormal Growth Plate Closure and Articular Cartilage Thickening in Postnatal Mice

(2009) Takahito Yuasa et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Mature Adipocyte-Derived Dedifferentiated Fat Cells Can Trans-Differentiate into Osteoblasts In Vitro and In Vivo only by All-Trans Retinoic Acid

(2009) Yoshinao Oki et al.   CELL STRUCTURE AND FUNCTION

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Bone Ridge Patterning during Musculoskeletal Assembly Is Mediated through SCX Regulation of Bmp4 at the Tendon-Skeleton Junction

(2009) Einat Blitz et al.   DEVELOPMENTAL CELL

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

(2008) N. Kamiya et al.   DEVELOPMENT

Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass*

(2008) Nobuhiro Kamiya et al.   JOURNAL OF BONE AND MINERAL RESEARCH