The Mammary Gland: Basic Structure and Molecular Signaling during Development

Estrogen receptor-α signaling in post-natal mammary development and breast cancers

(2021) Mariam Rusidzé et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mammary gland development from a single cell ‘omics view

(2021) Alecia-Jane Twigger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism

(2020) Chew Leng Lim et al.   eLife

Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships

(2019) Chi-Yeh Chung et al.   Cell Reports

Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia

(2018) Heng Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A 100-Year Review: Mammary development and lactation

(2017) R. Michael Akers   JOURNAL OF DAIRY SCIENCE

Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing

(2017) Karsten Bach et al.   Nature Communications

FGF10: A multifunctional mesenchymal–epithelial signaling growth factor in development, health, and disease

(2016) Nobuyuki Itoh   CYTOKINE & GROWTH FACTOR REVIEWS

Caught in a Wnt storm: Complexities of Wnt signaling in hematopoiesis

(2016) Frank J.T. Staal et al.   EXPERIMENTAL HEMATOLOGY

A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud

(2016) Ingrid Paine et al.   PLoS Computational Biology

Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium

(2015) Kevin Roarty et al.   JOURNAL OF CELL BIOLOGY

Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP-14

(2015) Angélica Maciel Gomes et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC

(2015) Mimmi S. Ballard et al.   Cell Reports

FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis

(2014) X. Zhang et al.   DEVELOPMENT

Epidermal Growth Factor Receptor (EGFR) Signaling Is a Key Mediator of Hormone-Induced Leukocyte Infiltration in the Pubertal Female Mammary Gland

(2014) Mark D. Aupperlee et al.   ENDOCRINOLOGY

Stromal Fibroblasts and the Immune Microenvironment: Partners in Mammary Gland Biology and Pathology?

(2014) Ashleigh Unsworth et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

In situ identification of bipotent stem cells in the mammary gland

(2014) Anne C. Rios et al.   NATURE

Correction: MMTV-Wnt1 and -ΔN89β-Catenin Induce Canonical Signaling in Distinct Progenitors and Differentially Activate Hedgehog Signaling within Mammary Tumors

(2014) Brigitte Teissedre et al.   PLoS One

How integrins control breast biology

(2013) Marina A Glukhova et al.   CURRENT OPINION IN CELL BIOLOGY

Expression and Functions of Fibroblast Growth Factor 10 in the Mouse Mammary Gland

(2013) Yingjun Cui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparative Aspects of Mammary Gland Development and Homeostasis

(2013) Anthony V. Capuco et al.   Annual Review of Animal Biosciences

Development of the Human Breast

(2013) Aida Lteif et al.   Seminars in Plastic Surgery

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin  1

(2012) H. Mori et al.   DEVELOPMENT

Fibroblast Growth Factor Receptor Signaling Is Essential for Normal Mammary Gland Development and Stem Cell Function

(2012) Adam C. Pond et al.   STEM CELLS

Mammary gland development

(2012) Hector Macias et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Molecular regulators of pubertal mammary gland development

(2011) Sara McNally et al.   ANNALS OF MEDICINE

TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model

(2011) Jing Liu et al.   BMC DEVELOPMENTAL BIOLOGY

Integrated morphodynamic signalling of the mammary gland

(2011) Nikolce Gjorevski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alternatively Activated Macrophages and Collagen Remodeling Characterize the Postpartum Involuting Mammary Gland across Species

(2010) Jenean O'Brien et al.   AMERICAN JOURNAL OF PATHOLOGY

Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis

(2010) Ricardo D Coletta et al.   BMC DEVELOPMENTAL BIOLOGY

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

(2010) Muh-Hwa Yang et al.   CELL CYCLE

Mechanics of head fold formation: investigating tissue-level forces during early development

(2010) V. D. Varner et al.   DEVELOPMENT

Morphogenesis of the developing mammary gland: Stage-dependent impact of adipocytes

(2010) Shira Landskroner-Eiger et al.   DEVELOPMENTAL BIOLOGY

Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland

(2010) Richard Jäger et al.   DEVELOPMENTAL DYNAMICS

s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue

(2010) L. Bai et al.   GENES & DEVELOPMENT

Constitutive overexpression of Id-1 in mammary glands of transgenic mice results in precocious and increased formation of terminal end buds, enhanced alveologenesis, delayed involution

(2010) Dong-Hui Shin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activin-related proteins in bovine mammary gland: Localization and differential expression during gestational development and differentiation

(2010) E. Bloise et al.   JOURNAL OF DAIRY SCIENCE

ErbB/EGF Signaling and EMT in Mammary Development and Breast Cancer

(2010) Katharine M. Hardy et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Extracellular Matrix Composition Reveals Complex and Dynamic Stromal-Epithelial Interactions in the Mammary Gland

(2010) Ori Maller et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

(2010) Daniel Schramek et al.   NATURE

miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development

(2010) Ahmet Ucar et al.   NATURE GENETICS

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

When pathways collide: collaboration and connivance among signalling proteins in development

(2010) Helen McNeill et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcription factor regulatory networks in mammary epithelial development and tumorigenesis

(2010) P M Siegel et al.   ONCOGENE

Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis

(2010) S. M. Knox et al.   SCIENCE

C/EBPβ Regulates Stem Cell Activity and Specifies Luminal Cell Fate in the Mammary Gland

(2010) Heather L. LaMarca et al.   STEM CELLS

Molecular Mechanisms Guiding Embryonic Mammary Gland Development

(2010) P. Cowin et al.   Cold Spring Harbor Perspectives in Biology

Mammary Gland Growth Factors: Roles in Normal Development and in Cancer

(2010) N. E. Hynes et al.   Cold Spring Harbor Perspectives in Biology

Hormone Action in the Mammary Gland

(2010) C. Brisken et al.   Cold Spring Harbor Perspectives in Biology

Mammary Gland Reprogramming: Metalloproteinases Couple Form with Function

(2010) R. Khokha et al.   Cold Spring Harbor Perspectives in Biology

Cell-Matrix Interactions in Mammary Gland Development and Breast Cancer

(2010) J. Muschler et al.   Cold Spring Harbor Perspectives in Biology

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Loss of protein kinase C delta alters mammary gland development and apoptosis

(2010) B L Allen-Petersen et al.   Cell Death & Disease

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Signal co-operation between integrins and other receptor systems

(2009) Charles H. Streuli et al.   BIOCHEMICAL JOURNAL

Wnt4 is not sufficient to induce lobuloalveolar mammary development

(2009) Young Kim et al.   BMC DEVELOPMENTAL BIOLOGY

The cytoskeleton and cancer

(2009) Alan Hall   CANCER AND METASTASIS REVIEWS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

Differential Effects of Mechanical and Biological Stimuli on Matrix Metalloproteinase Promoter Activation in the Thoracic Aorta

(2009) J. M. Ruddy et al.   CIRCULATION

EMT 2.0: shaping epithelia through collective migration

(2009) Céline Revenu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Developmental and Pathogenic Mechanisms of Basement Membrane Assembly

(2009) Peter Yurchenco et al.   CURRENT PHARMACEUTICAL DESIGN

Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis

(2009) Y. Liu et al.   DEVELOPMENT

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation

(2009) N. Akhtar et al.   DEVELOPMENT

The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse

(2009) Rodrigo Fernandez-Valdivia et al.   DEVELOPMENTAL BIOLOGY

The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis

(2009) Sara E. Meyer et al.   DEVELOPMENTAL BIOLOGY

Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: Failure of Stat5 activation and functional differentiation in the absence of Elf5

(2009) Yeon Sook Choi et al.   DEVELOPMENTAL BIOLOGY

Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis

(2009) Jennifer N. Lilla et al.   DEVELOPMENTAL BIOLOGY

Inhibition of Endothelial Cell Apoptosis by Netrin-1 during Angiogenesis

(2009) Marie Castets et al.   DEVELOPMENTAL CELL

Integrin Acts Upstream of Netrin Signaling to Regulate Formation of the Anchor Cell's Invasive Membrane in C. elegans

(2009) Elliott J. Hagedorn et al.   DEVELOPMENTAL CELL

MT2-MMP-Dependent Release of Collagen IV NC1 Domains Regulates Submandibular Gland Branching Morphogenesis

(2009) Ivan T. Rebustini et al.   DEVELOPMENTAL CELL

Diet-induced obesity disrupts ductal development in the mammary glands of nonpregnant mice

(2009) Akihiro Kamikawa et al.   DEVELOPMENTAL DYNAMICS

Analysis of gene expression in PTHrP−/−mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis

(2009) Julie Hens et al.   DEVELOPMENTAL DYNAMICS

Growth Hormone and Insulin-Like Growth Factor-I in the Transition from Normal Mammary Development to Preneoplastic Mammary Lesions

(2009) David L. Kleinberg et al.   ENDOCRINE REVIEWS

Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility

(2009) Martine H. A. M. van Miltenburg et al.   FASEB JOURNAL

A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression

(2009) M. Yu et al.   GENES & DEVELOPMENT

Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis

(2009) Jane E. Visvader   GENES & DEVELOPMENT

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

(2009) Ljiljana Milenkovic et al.   JOURNAL OF CELL BIOLOGY

Defining a role for the homeoprotein Six1 in EMT and mammary tumorigenesis

(2009) Derek C. Radisky   JOURNAL OF CLINICAL INVESTIGATION

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Filamin A–β1 Integrin Complex Tunes Epithelial Cell Response to Matrix Tension

(2009) Scott Gehler et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Mammary Gland Branching Morphogenesis by EphA2 Receptor Tyrosine Kinase

(2009) David Vaught et al.   MOLECULAR BIOLOGY OF THE CELL

FGF signalling during embryo development regulates cilia length in diverse epithelia

(2009) Judith M. Neugebauer et al.   NATURE

Integrins: masters and slaves of endocytic transport

(2009) Patrick T. Caswell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Wnt Co-Receptor Lrp6 Is Required for Normal Mouse Mammary Gland Development

(2009) Charlotta Lindvall et al.   PLoS One

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Up-Regulation of MSX2 Enhances the Malignant Phenotype and Is Associated with Twist 1 Expression in Human Pancreatic Cancer Cells

(2008) Kennichi Satoh et al.   AMERICAN JOURNAL OF PATHOLOGY

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

(2008) Stefania Cannito et al.   CARCINOGENESIS

Polarized fluid movement and not cell death, creates luminal spaces in adult prostate epithelium

(2008) J F Pearson et al.   CELL DEATH AND DIFFERENTIATION

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

(2008) Toula Bouras et al.   Cell Stem Cell

Mammary development in the embryo and adult: a journey of morphogenesis and commitment

(2008) C. J. Watson et al.   DEVELOPMENT

Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling

(2008) Sara Parsa et al.   DEVELOPMENTAL BIOLOGY

Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis

(2008) Pengfei Lu et al.   DEVELOPMENTAL BIOLOGY

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

(2008) Andrew J. Ewald et al.   DEVELOPMENTAL CELL

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

(2008) Jordi Alcaraz et al.   EMBO JOURNAL

Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction

(2008) Liliana Schaefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells

(2008) Maria Lombardi et al.   JOURNAL OF CELL BIOLOGY

Amphiregulin: Role in Mammary Gland Development and Breast Cancer

(2008) Jean McBryan et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Mechanistic Aspects of Crosstalk Between GH and PRL and ErbB Receptor Family Signaling

(2008) Stuart J. Frank   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Prolactin Regulation of Mammary Gland Development

(2008) Samantha R. Oakes et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development

(2008) David L. Kleinberg et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The ADAM17–amphiregulin–EGFR Axis in Mammary Development and Cancer

(2008) Mark D. Sternlicht et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Prolactin and ErbB4/HER4 Signaling Interact via Janus Kinase 2 to Induce Mammary Epithelial Cell Gene Expression Differentiation

(2008) Rebecca S. Muraoka-Cook et al.   MOLECULAR ENDOCRINOLOGY

β1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells

(2008) Ilaria Taddei et al.   NATURE CELL BIOLOGY

Decorin promotes robust axon growth on inhibitory CSPGs and myelin via a direct effect on neurons

(2008) Kenneth Minor et al.   NEUROBIOLOGY OF DISEASE

Patterning Mechanisms of Branched Organs

(2008) P. Lu et al.   SCIENCE

Epithelial Cells Remove Apoptotic Epithelial Cells During Post-Lactation Involution of the Mouse Mammary Gland1

(2007) Jenifer Monks et al.   BIOLOGY OF REPRODUCTION

Bridging structure with function: Structural, regulatory, and developmental role of laminins

(2007) Julia Tzu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Fragments of extracellular matrix as mediators of inflammation

(2007) T ADAIRKIRK et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dynamic Expression of Erbb Pathway Members during Early Mammary Gland Morphogenesis

(2007) Olivia Wansbury et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY