Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling

Adrenal G protein-coupled receptors and the failing heart

(2022) Jordana I. Borges et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling

(2022) Selma E. Anton et al.   CELL

Short-Chain Fatty Acid Receptors and Cardiovascular Function

(2022) Anastasios Lymperopoulos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiovascular Inflammaging: Mechanisms and Translational Aspects

(2022) Maria Luisa Barcena et al.   Cells

Signaling and function of cardiac autonomic nervous system receptors: Insights from the GPCR signalling universe

(2021) Anastasios Lymperopoulos et al.   FEBS Journal

Sympatholytic Mechanisms for the Beneficial Cardiovascular Effects of SGLT2 Inhibitors: A Research Hypothesis for Dapagliflozin’s Effects in the Adrenal Gland

(2021) Anastasios Lymperopoulos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum Free Fatty Acids Independently Predict Adverse Outcomes in Acute Heart Failure Patients

(2021) Yi Yu et al.   Frontiers in Cardiovascular Medicine

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition

(2020) Jennifer Maning et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Free Fatty Acid Receptors 2 and 3 as Microbial Metabolite Sensors to Shape Host Health: Pharmacophysiological View

(2020) Sidharth P. Mishra et al.   Biomedicines

A Global Map of G Protein Signaling Regulation by RGS Proteins

(2020) Ikuo Masuho et al.   CELL

Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

(2020) Xinyu Xu et al.   CELL RESEARCH

Deletion of Osteopontin Enhances β2-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes

(2019) Celina Pollard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Free Fatty Acid Receptors in Health and Disease

(2019) Ikuo Kimura et al.   PHYSIOLOGICAL REVIEWS

Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials

(2019) Joseph B. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease

(2018) Katherine E. Squires et al.   PHARMACOLOGICAL REVIEWS

Regulators of G-Protein Signaling in Cardiovascular Function During Pregnancy

(2018) Katherine J. Perschbacher et al.   PHYSIOLOGICAL GENOMICS

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

(2018) Guoliang Lyu et al.   Nature Communications

β-Arrestin2 Improves Post–Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca 2+ -ATPase–Dependent Positive Inotropy in CardiomyocytesNovelty and Significance

(2017) Katie A. McCrink et al.   HYPERTENSION

GRK2 Up-Regulation Creates a Positive Feedback Loop for Catecholamine Production in Chromaffin Cells

(2016) Malika Jafferjee et al.   MOLECULAR ENDOCRINOLOGY

GPCR signaling and cardiac function

(2015) Leany A. Capote et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling

(2015) Aaisha Opel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3

(2013) Chia-Wei Phan et al.   BMC Complementary and Alternative Medicine

GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility

(2013) Norma C Salazar et al.   Cell Communication and Signaling

Adrenergic Nervous System in Heart Failure

(2013) Anastasios Lymperopoulos et al.   CIRCULATION RESEARCH

Plasma Free Fatty Acids and Risk of Heart Failure

(2013) Luc Djoussé et al.   Circulation-Heart Failure

Tools for GPCR drug discovery

(2012) Ru Zhang et al.   ACTA PHARMACOLOGICA SINICA

β-Adrenergic receptor subtype signaling in heart: From bench to bedside

(2012) Anthony Yiu Ho Woo et al.   ACTA PHARMACOLOGICA SINICA

Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation

(2012) Daisuke Inoue et al.   FEBS LETTERS

Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node

(2012) Alexandra S. Mighiu et al.   Frontiers in Physiology

RGS proteins in heart: brakes on the vagus

(2012) Adele Stewart   Frontiers in Physiology

Regulators of G-Protein Signaling in the Heart and Their Potential as Therapeutic Targets

(2011) Peng Zhang et al.   CIRCULATION RESEARCH

Short-Chain Fatty Acid Propionate Alleviates Akt2 Knockout-Induced Myocardial Contractile Dysfunction

(2011) Linlin Li et al.   Experimental Diabetes Research

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction

(2010) Anastasios Lymperopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differentiation of mouse Neuro 2A cells into dopamine neurons

(2009) Roger G. Tremblay et al.   JOURNAL OF NEUROSCIENCE METHODS

RGS4 Regulates Parasympathetic Signaling and Heart Rate Control in the Sinoatrial Node

(2008) Carlo Cifelli et al.   CIRCULATION RESEARCH