Regulators of G-Protein Signaling in the Heart and Their Potential as Therapeutic Targets

Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses

(2011) Peng Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gαi2-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart

(2011) Rachael E. Waterson et al.   CARDIOVASCULAR RESEARCH

RGS2 is a primary terminator of β2-adrenergic receptor-mediated Gi signaling

(2011) Khalid Chakir et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Taking the heart failure battle inside the cell: Small molecule targeting of Gβγ subunits

(2011) Fadia A. Kamal et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulator of G protein-signaling proteins and addictive drugs

(2010) John Traynor   Annals of the New York Academy of Sciences

Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2

(2010) Michael Klaiber et al.   BASIC RESEARCH IN CARDIOLOGY

Non-canonical functions of RGS proteins

(2010) Nan Sethakorn et al.   CELLULAR SIGNALLING

RGS2 inhibits β-adrenergic receptor-induced cardiomyocyte hypertrophy

(2010) Caroline Nunn et al.   CELLULAR SIGNALLING

RGS6/Gβ5 Complex Accelerates I KACh Gating Kinetics in Atrial Myocytes and Modulates Parasympathetic Regulation of Heart Rate

(2010) Ekaterina Posokhova et al.   CIRCULATION RESEARCH

RGS6, a Modulator of Parasympathetic Activation in Heart

(2010) Jianqi Yang et al.   CIRCULATION RESEARCH

DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation

(2010) Jincheng Wang et al.   FEBS LETTERS

Thinking Outside of the "RGS Box": New Approaches to Therapeutic Targeting of Regulators of G Protein Signaling

(2010) B. Sjogren et al.   MOLECULAR PHARMACOLOGY

Allosteric Inhibition of the Regulator of G Protein Signaling-G  Protein-Protein Interaction by CCG-4986

(2010) D. L. Roman et al.   MOLECULAR PHARMACOLOGY

Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins

(2010) L. L. Blazer et al.   MOLECULAR PHARMACOLOGY

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of RGS13 by the Cyclic AMP-dependent Protein Kinase Inhibits RGS13 Degradation

(2010) Z. Xie et al.   Journal of Molecular Cell Biology

Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse

(2009) Jari M. Tuomi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulator of G-protein signaling (RGS) proteins in cancer biology

(2009) Jillian H. Hurst et al.   BIOCHEMICAL PHARMACOLOGY

Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4

(2009) Y. Xie et al.   CANCER RESEARCH

Cardiac regulation by phosphoinositide 3-kinases and PTEN

(2009) G. Y. Oudit et al.   CARDIOVASCULAR RESEARCH

The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling

(2009) Garret R. Anderson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways

(2009) Feng-jue Shu et al.   CELLULAR SIGNALLING

RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function

(2009) Steven Gu et al.   CLINICAL SCIENCE

RGS16 Inhibits Breast Cancer Cell Growth by Mitigating Phosphatidylinositol 3-Kinase Signaling

(2009) Genqing Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

(2009) Adam J. Kimple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational control by RGS2

(2009) Chau H. Nguyen et al.   JOURNAL OF CELL BIOLOGY

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

(2009) Norifumi Takeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation and Physiological Functions of G12/13-Mediated Signaling Pathways

(2009) Nobuchika Suzuki et al.   NEUROSIGNALS

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector

(2009) Francis S. Willard et al.   PLoS One

Regulator of G Protein Signaling 5: A New Player in Vascular Remodeling

(2009) Mitali Manzur et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Regulator of G-Protein Signaling Subtype 4 Mediates Antihypertrophic Effect of Locally Secreted Natriuretic Peptides in the Heart

(2008) Takeshi Tokudome et al.   CIRCULATION

Nuclear α1-Adrenergic Receptors Signal Activated ERK Localization to Caveolae in Adult Cardiac Myocytes

(2008) Casey D. Wright et al.   CIRCULATION RESEARCH

RGS4 Regulates Parasympathetic Signaling and Heart Rate Control in the Sinoatrial Node

(2008) Carlo Cifelli et al.   CIRCULATION RESEARCH

The intracellular renin???angiotensin system: implications in cardiovascular remodeling

(2008) Rajesh Kumar et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Regulation of G protein-coupled receptor signalling: Focus on the cardiovascular system and regulator of G protein signalling proteins

(2008) Mariëlle C. Hendriks-Balk et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of G-protein-coupled signaling pathways in allergic inflammation

(2008) Kirk M. Druey   IMMUNOLOGIC RESEARCH

Generation and Characterization of rgs5 Mutant Mice

(2008) M. H. Nisancioglu et al.   MOLECULAR AND CELLULAR BIOLOGY

Rgs5 Targeting Leads to Chronic Low Blood Pressure and a Lean Body Habitus

(2008) H. Cho et al.   MOLECULAR AND CELLULAR BIOLOGY

RGS13 Acts as a Nuclear Repressor of CREB

(2008) Zhihui Xie et al.   MOLECULAR CELL

Regulation of Smad-Mediated Gene Transcription by RGS3

(2008) D. M. Yau et al.   MOLECULAR PHARMACOLOGY

Crystal structure of the multifunctional Gβ5–RGS9 complex

(2008) Matthew L Cheever et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of Peptides That Inhibit Regulator of G Protein Signaling 4 Function

(2008) Yuren Wang et al.   PHARMACOLOGY

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein  -subunits

(2008) M. Soundararajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling

(2008) Muralidharan Jayaraman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES