Uncoupling Protein 1 Does Not Produce Heat without Activation

The Molecular Brakes of Adipose Tissue Lipolysis

(2022) Yongguo Li et al.   Frontiers in Physiology

An improved method for the precise unravelment of non-shivering brown fat thermokinetics

(2021) Rebecca Oelkrug et al.   Scientific Reports

Isothermal microcalorimetry measures UCP1-mediated thermogenesis in mature brite adipocytes

(2021) Muhammad Hamza Bokhari et al.   Communications Biology

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1

(2021) Sebastian Dieckmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial H+ Leak and Thermogenesis

(2021) Ambre M. Bertholet et al.   Annual Review of Physiology

Purine Nucleotides in the Regulation of Brown Adipose Tissue Activity

(2020) Andrea Bast-Habersbrunner et al.   Frontiers in Endocrinology

Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

(2020) Denis P. Blondin et al.   Cell Metabolism

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

(2020) Putianqi Wang et al.   NATURE

A discrete neuronal circuit induces a hibernation-like state in rodents

(2020) Tohru M. Takahashi et al.   NATURE

Neurons that regulate mouse torpor

(2020) Sinisa Hrvatin et al.   NATURE

Uncoupling protein 1 expression does not protect mice from diet-induced obesity

(2020) Hui Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Eicosapentaenoic Acid Reduces Adiposity, Glucose Intolerance and Increases Oxygen Consumption Independently of Uncoupling Protein 1

(2019) Mandana Pahlavani et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Bile acid supplementation decreases body mass gain in C57BL/6J but not 129S6/SvEvTac mice without increasing energy expenditure

(2019) Tobias Fromme et al.   Scientific Reports

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue

(2019) Wenxin Song et al.   PLOS BIOLOGY

Fat cells gobbling up norepinephrine?

(2019) Vitaly Ryu et al.   PLOS BIOLOGY

In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain

(2019) Ineke H.N. Luijten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis

(2019) Xing Zeng et al.   NATURE

Repeatability of brown adipose tissue measurements on FDG PET/CT following a simple cooling procedure for BAT activation

(2019) John P. Crandall et al.   PLoS One

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

(2019) Kornelia Johann et al.   Cell Reports

Uncoupling protein 1 and the capacity for non-shivering thermogenesis are components of the glucose homeostatic system

(2019) Stefanie F. Maurer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Beta-1 and not beta-3-adrenergic receptors may be the primary regulator of human brown adipocyte metabolism

(2019) Mette Ji Riis-Vestergaard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nature's fat-burning machine: brown adipose tissue in a hibernating mammal

(2018) Mallory A. Ballinger et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Non-adrenergic control of lipolysis and thermogenesis in adipose tissues

(2018) Katharina Braun et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Whole-tissue 3D imaging reveals intra-adipose sympathetic plasticity regulated by NGF-TrkA signal in cold-induced beiging

(2018) Ying Cao et al.   Protein & Cell

Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

(2018) Tobias Fromme et al.   Molecular Metabolism

Transient Overexpression of VEGF-A in Adipose Tissue Promotes Energy Expenditure via Activation of the Sympathetic Nervous System

(2018) Yueshui Zhao et al.   MOLECULAR AND CELLULAR BIOLOGY

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

(2018) Alexander W. Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

(2018) Yongguo Li et al.   CELL

Brown Adipose Tissue—A Therapeutic Target in Obesity?

(2018) Paul Trayhurn   Frontiers in Physiology

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

(2017) Christina D. Camell et al.   NATURE

Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

(2017) Roksana M Pirzgalska et al.   NATURE MEDICINE

Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches

(2017) Ryan Walker-Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Body Temperature Measurements for Metabolic Phenotyping in Mice

(2017) Carola W. Meyer et al.   Frontiers in Physiology

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes

(2017) Rókus Kriszt et al.   Scientific Reports

Difference in intracellular temperature rise between matured and precursor brown adipocytes in response to uncoupler and β-adrenergic agonist stimuli

(2017) Toshikazu Tsuji et al.   Scientific Reports

Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice

(2016) Marika Zietak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Parathyroid hormone induces adipocyte lipolysis via PKA-mediated phosphorylation of hormone-sensitive lipase

(2016) Sara Larsson et al.   CELLULAR SIGNALLING

Human brown adipose tissue [15O]O2 PET imaging in the presence and absence of cold stimulus

(2016) Mueez u Din et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Sarcolipin and uncoupling protein 1 play distinct roles in diet-induced thermogenesis and do not compensate for one another

(2016) Leslie A. Rowland et al.   Obesity

Brown, Beige, and White: The New Color Code of Fat and Its Pharmacological Implications

(2015) Alexander Pfeifer et al.   Annual Review of Pharmacology and Toxicology

Miniaturized implantable sensors for in vivo localized temperature measurements in mice during cold exposure

(2015) R. Padovani et al.   BIOMEDICAL MICRODEVICES

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by β-Adrenergic Receptors in Brown Adipocytes

(2015) Kana Oue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice

(2015) Stefanie F. Maurer et al.   Scientific Reports

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes

(2014) Y. Li et al.   EMBO REPORTS

The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality

(2014) Margalit Goldgof et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular rarefaction mediates whitening of brown fat in obesity

(2014) Ippei Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

UCP1 mRNA does not produce heat

(2013) Jan Nedergaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

White, brite, and brown adipocytes: the evolution and function of a heater organ in mammals

(2013) Yongguo Li et al.   CANADIAN JOURNAL OF ZOOLOGY

15O PET Measurement of Blood Flow and Oxygen Consumption in Cold-Activated Human Brown Fat

(2013) O. Muzik et al.   JOURNAL OF NUCLEAR MEDICINE

Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak

(2012) Martin Jastroch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice

(2010) Carola W. Meyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Uncoupling protein 1 expression and high-fat diets

(2010) Tobias Fromme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Uncoupling protein-1 is not leaky

(2010) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Sympathetic and sensory innervation of brown adipose tissue

(2010) T J Bartness et al.   INTERNATIONAL JOURNAL OF OBESITY

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

(2010) Yihai Cao   NATURE REVIEWS DRUG DISCOVERY

One for all and all for one: the energetic benefits of huddling in endotherms

(2009) Caroline Gilbert et al.   BIOLOGICAL REVIEWS

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

(2009) Yuan Xue et al.   Cell Metabolism

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria

(2009) Nadeene Parker et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARγ agonist

(2008) Natasa Petrovic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rarefaction of the Peripheral Nerve Network in Diabetic Patients Is Associated With a Pronounced Reduction of Terminal Schwann Cells

(2008) C. M. Reinisch et al.   DIABETES CARE

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling