Reactivation of p53 mutants by p53 reactivation and induction of massive apoptosis in thyroid cancer cells

In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription

(2011) Cinzia Puppin et al.   CELLULAR ONCOLOGY

PRIMA-1MET/APR-246 targets mutant forms of p53 family members p63 and p73

(2010) N Rökaeus et al.   ONCOGENE

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis

(2009) J M R Lambert et al.   ONCOGENE

A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis

(2008) L Weinmann et al.   CELL DEATH AND DIFFERENTIATION

PRIMA-1 synergizes with adriamycin to induce cell death in non-small cell lung cancer cells

(2008) R. Magrini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TAp73  Increases p53 Tumor Suppressor Activity in Thyroid Cancer Cells via the Inhibition of Mdm2-Mediated Degradation

(2008) R. Malaguarnera et al.   MOLECULAR CANCER RESEARCH

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA