Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking

Rab GTPase regulation of membrane identity

(2013) Suzanne R Pfeffer   CURRENT OPINION IN CELL BIOLOGY

Synthesis of Indole Analogues of the Natural Schweinfurthins

(2013) John G. Kodet et al.   JOURNAL OF ORGANIC CHEMISTRY

PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma

(2013) M. Pfeifer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing

(2012) Carl J. Mousley et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking

(2011) Ximing Du et al.   JOURNAL OF CELL BIOLOGY

Pleiotropic Effects of a Schweinfurthin on Isoprenoid Homeostasis

(2011) Sarah A. Holstein et al.   LIPIDS

Natural products reveal cancer cell dependence on oxysterol-binding proteins

(2011) Anthony W G Burgett et al.   Nature Chemical Biology

Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

(2011) Hong Wa Yung et al.   PLoS One

Membrane trafficking and signaling: Two sides of the same coin

(2011) Pauline Gonnord et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Physiology and Pathology of Endosome-to-Golgi Retrograde Sorting

(2011) Christopher G. Burd   TRAFFIC

Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network

(2011) Felipe H. Santiago-Tirado et al.   TRENDS IN CELL BIOLOGY

High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

(2011) Lydia W.T. Cheung et al.   Cancer Discovery

The Diverse Functions of Oxysterol-Binding Proteins

(2010) Sumana Raychaudhuri et al.   Annual Review of Cell and Developmental Biology

Fluorescent schweinfurthin B and F analogs with anti-proliferative activity

(2010) Joseph J. Topczewski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD-Dependent Manner

(2010) T. J. Turbyville et al.   MOLECULAR CANCER THERAPEUTICS

Critical role of PI3K signaling for NF- B-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells

(2010) B. Kloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivesicular Body Formation Requires OSBP–Related Proteins and Cholesterol

(2010) Hiroyuki Kobuna et al.   PLoS Genetics

PtdIns4Precognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking

(2009) Christopher S. Wood et al.   JOURNAL OF CELL BIOLOGY

NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth

(2009) M. F. James et al.   MOLECULAR AND CELLULAR BIOLOGY

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

(2009) Kenneth L. Scott et al.   NATURE

Tumor suppressor function of laminin-binding  -dystroglycan requires a distinct  3-N-acetylglucosaminyltransferase

(2009) X. Bao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE