Article
Engineering, Chemical
Suyang Pan, Jiliang Ma, Daoyin Liu, Xiaoping Chen, Cai Liang
Summary: This paper studies the liquid transport behaviors in a top-sprayed fluidized bed using bed conductance analysis, pressure fluctuation analysis, and bubble image processing. The results show that liquid initially gets trapped in agglomerates before converting to free liquid and spreading from the upper-middle bed to the bottom bed. The disintegrating pattern of agglomerates affects the increase and saturation of free liquid in the bed. The liquid transport process is accelerated by increasing superficial air velocity and particle diameter, while it slows down with increased liquid viscosity and surface tension.
Article
Engineering, Multidisciplinary
Fria Hossein, Massimiliano Materazzi, Matteo Errigo, Panagiota Angeli, Paola Lettieri
Summary: This paper describes the application of ultrasound techniques in solid-liquid fluidized beds, including the measurement of velocity profiles, particle size distribution, and solids volume fraction. The results indicate that ultrasound techniques are important for real-time characterization of highly concentrated solid-liquid systems.
Article
Engineering, Chemical
Jian Peng, Wei Sun, Guangming Zhou, Le Xie, Haisheng Han, Yao Xiao
Summary: In this study, machine learning models were developed to predict bed expansion ratio, with XGBoost model showing the strongest regression and prediction ability. The relative importance of operating conditions on bed expansion ratios was found to be particle size > particle density > superficial velocity.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Engineering, Chemical
Gongpeng Wu, Mingjian Zhang, Yan He
Summary: Research on solid mixing in multistage circulating fluidized beds reveals characteristics such as increased solid mean residence time and dispersion with higher solid flux. Diffusion coefficient in enlarged sections decreases with height, contrary to traditional risers. These findings indicate enhanced overall solid mixing in the multistage riser compared to traditional systems.
Article
Engineering, Environmental
M. J. A. de Munck, M. Dullemond, E. A. J. F. Peters, J. A. M. Kuipers
Summary: Fluidized bed drying is a dynamic process that involves changes in bed hydrodynamics, mass and heat transfer, and segregation and mixing tendencies over time. This study used pseudo-2D fluidized bed experiments with binary and ternary solid mixtures to investigate these dynamics. The results, obtained through particle image velocimetry infrared thermography technique and machine learning algorithm, revealed significant hydrodynamic changes and various segregation and mixing tendencies due to water evaporation from the porous gamma-Al2O3 material. The competition between size and density-based segregation and mixing dynamics resulted in changing bed configurations and influenced the local drying behavior. The study also highlighted the potential benefits of drying wider size distributions for more complex and efficient process operation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Chemical
Wenjian Cai, Shuyan Wang, Xiaoxue Jiang, Hassan Muhammad, Huilin Lu
Summary: This study simulated the mixing process of SC and LC binary mixture in a supercritical carbon dioxide fluidized bed using unequal granular temperature-based kinetic theory, and identified the mixing/segregation tendency between the two components based on synergy angle.
Article
Engineering, Chemical
Wenjian Cai, Shuyan Wang, Mustafa Ahmed Khogley Ahmed, Weiqi Chen, Huilin Lu
Summary: Numerical simulations were conducted to investigate the mixing and segregation of flotsam and jetsam components in a binary mixture in a supercritical water fluidized bed. The results indicated that increasing the temperature and fluidizing velocity of the supercritical water contributes to the mixing of the components along the bed height.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Engineering, Chemical
Tolu Emiola-Sadiq, Jiachen Wang, Lifeng Zhang, Ajay Dalai
Summary: This study experimentally investigated the mixing and segregation of binary mixtures involving biomass materials in a fluidized bed, focusing on the axial and radial distribution of biomass particles. Results showed that increasing fluidizing velocity improved mixing extent, while the mixing index decreased beyond a certain biomass loading threshold.
Article
Engineering, Chemical
Zhouzun Xie, Shuai Wang, Yansong Shen
Summary: In this study, a recent smoothed CFD-DEM model is used to investigate segregation and mixing behaviors in a bi-disperse solid-liquid fluidized bed with different superficial liquid velocities and wide size ratios. Results show that the mixing index effectively quantifies segregation degree, with circulation motion of particles and liquid confirmed in the transition zone, and hydrodynamics and collision being the main underlying mechanism of segregation behavior in the bi-disperse SLFB.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Thermodynamics
Jun Young Kim, Dongjae Kim, Zezhong John Li, Claudio Dariva, Yankai Cao, Naoko Ellis
Summary: Machine learning was used to predict the yield of biomass gasification, and the results showed that Random Forest and Artificial Neural Network had high prediction accuracy. The Monte Carlo filtering method was used to forecast the desired products and identify significant variables for optimization.
Article
Engineering, Chemical
Tian Nan, Jesse Zhu
Summary: The hydrodynamics of inverse liquid-solid circulating fluidized bed were studied comprehensively, revealing specific flow patterns and solid distribution laws, influenced by factors such as particle size and flow velocity.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Engineering, Environmental
Aiming Deng, Tianqi Tang, Shanshan Sun, Yurong He
Summary: Wet granulation processes are widely used in various industries, and the impact of injection gas velocity, droplet diameter, and injection liquid viscosity on particle growth ratio and coating thickness distribution was investigated in this study. By decreasing droplet diameter and increasing gas velocity, the particle growth area was significantly expanded, leading to increased collision frequency and decreased liquid content, ultimately improving particle quality and uniformity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Chemical
Le Xie, Jundong Zhu, Chongwen Jiang
Summary: A new three-fluid Eulerian model coupled with kinetic theory was developed to investigate mixing behaviors of binary-mixture particles in a pilot-scale fluidized bed reactor. The numerical results show that size segregation of particles can be easily achieved under high air velocity and large particle size ratio conditions.
Article
Engineering, Chemical
Yunxiang Zhao, Lihui Zhang, Feng Duan
Summary: The study found that superficial gas velocity plays a significant role in the mixing transition characteristics of binary particles, dividing the mixing behavior into three patterns: complete segregation, transitional mixing, and complete mixing. In the stage of complete mixing, the energy in the medium-frequency band of the IMF is the largest, and its value remains unchanged.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Zhenjiang Zhao, Ling Zhou, Ling Bai, Wanning Lv, Ramesh K. Agarwal
Summary: The reliability of numerical simulations was verified by conducting high-speed photographic experiments to investigate the evolution process of bubbles and the variation of bed height. The gas-solid flow characteristics of bubbling fluidized beds with different particle diameters and inlet flow rates were systematically studied. The results provide theoretical guidance for particle flow characteristics in biomass fluidized beds.
Article
Business, Finance
Wenjing Huang, Xinyu Gu, Linting Lin, Majed Alharthi, Muhammad Usman
Summary: SSA countries in Sub-Saharan Africa are facing challenges due to lower levels of human capital compared to developed countries. They are also striving to develop their financial sectors by offering improved products and services. This study examines the impact of financial inclusion and income inequality on human capital in SSA countries and finds that higher financial inclusion and reduced income inequality have a positive effect. The study uses panel data from 36 SSA countries from 2004 to 2019, controlling for other economic indicators, and confirms the robustness of the results when SSA economies have a high level of education.
BORSA ISTANBUL REVIEW
(2023)
Article
Engineering, Chemical
Zhouzun Xie, Shuai Wang, Yansong Shen
Summary: This study numerically investigates the formation and connection of clusters in a porous medium and reveals the clogging mechanism of fine particles at the pore scale. By developing a probabilistic model, an exponential correlation between cluster size and clogging ability is obtained, providing an effective method to quantify clogging ability.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Thermodynamics
Xinyu Gu, K. W. See, Penghua Li, Kangheng Shan, Yunpeng Wang, Liang Zhao, Kai Chin Lim, Neng Zhang
Summary: This study proposes a novel approach for estimating the state-of-health (SOH) of lithium-ion batteries using data pre-processing methods and a convolutional neural network (CNN)-Transformer framework. The proposed model demonstrates high accuracy and stability in estimating the battery SOH.
Article
Telecommunications
Boyuan Zhang, Haozhen Li, Xin Liang, Xinyu Gu, Lin Zhang
Summary: This research proposes a multi-task training approach to improve the feasibility of the feedback network. An encoder-shared feedback architecture and training procedure are designed to facilitate the implementation of this approach. The experimental results show that the multi-task training approach can achieve comprehensive feedback performance with reduced training cost and storage usage of the feedback model.
IEEE COMMUNICATIONS LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Mingliang Chen, Zhihao Shi, Yuqiu Sun, Haoran Ning, Xinyu Gu, Lei Zhang
Summary: Ferroptosis is a novel form of iron-dependent cell death that is distinct from apoptosis, necrosis, and autophagy. Glutathione peroxidase 4 (GPX4) plays a critical role in protecting cells from ferroptosis. Research on ferroptosis in cancer therapy, especially in acquired drug resistance, has led to the development of therapeutic drugs targeting GPX4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qingmiao Shi, Xin Yuan, Chen Xue, Xinyu Gu, Lanjuan Li
Summary: This study identified two molecular subtypes based on bile acid and bile salt metabolism-related genes, and established a risk model that can effectively predict the prognosis of patients with liver cancer and their immunotherapeutic response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Cagla Sahin, Aikaterini Motso, Xinyu Gu, Hannes Feyrer, Dilraj Lama, Tina Arndt, Anna Rising, Genis Valentin Gese, B. Martin Haellberg, Erik. G. Marklund, Nicholas P. Schafer, Katja Petzold, Kaare Teilum, Peter G. Wolynes, Michael Landreh
Summary: Liquid-liquid phase separation (LLPS) of heterogeneous ribonucleoproteins (hnRNPs) was studied using protein engineering, native ion mobility mass spectrometry, and molecular dynamics simulations. The experiments focused on hnRNPs FUS, TDP-43, and hCPEB3 involved in neurodegeneration, cancer, and memory storage. Conformational changes associated with LLPS were monitored by releasing the proteins inside the mass spectrometer from their native assemblies. The results revealed different assembly mechanisms and potentially different impacts on RNA processing and translation depending on the protein species.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Letter
Clinical Neurology
Xinyu Gu, Dongyue Yue, Kai Qiao, Guoqian Huang, Wenhua Zhu, Jianying Xi, Hui Zhu
Article
Chemistry, Organic
Zi-Xuan Ma, Shi-Chao Wang, Xin-Yu Gu, Shu-Liang Wang, Wen-Juan Hao, Bo Jiang
Summary: A concise and operationally simple photocatalysis strategy for the annulative cyanoalkyletherification of 1,6-enynes with cyclic oxime esters and alcohols is reported, producing a set of functionalized 1-indanones bearing an all-carbon quaternary center with generally good yields. In this process, single electron reduction of cyclic oxime esters drives deconstructive carbon-carbon s-bond cleavage to yield a key cyanopropyl radical poised for addition-cyclization. This reaction is redox-neutral and demonstrates good functional group compatibility and a wide substrate scope, in which diversified alcohols can be engaged in the annulation reaction to prepare exocyclic vinyl ethers.
Article
Immunology
Xiaoyue Li, Yongxiang Yi, Tongxin Wu, Nan Chen, Xinyu Gu, Liangliang Xiang, Zhaodi Jiang, Junwei Li, Heiying Jin
Summary: This study examined the composition of the gut microbiota and serum metabolic profiles in patients with HCC, LC, and healthy individuals. It found significant differences in the gut microbiota and serum metabolites between HCC patients and non-HCC patients. The study identified two key species and five key metabolites associated with HCC, which may serve as potential markers for HCC diagnosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Liangliang Xiang, Yun Li, Xinyu Gu, Shujie Li, Junwei Li, Jinlong Li, Yongxiang Yi
Summary: A novel nucleolin-responsive nanoparticle platform was developed for simultaneous detection and treatment of liver cancer. The platform incorporated AS1411 aptamer, icaritin (ICT) and FITC into mesoporous silica nanoparticles, allowing specific release of FITC and ICT in response to target nucleolin. The platform could detect nucleolin through fluorescence intensity monitoring and induce apoptosis in vitro and in vivo. The results demonstrated low toxicity and CD3(+) T-cell infiltration, suggesting the potential of the platform for liver cancer identification and treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chen Xue, Xinyu Gu, Qiuxian Zheng, Qingmiao Shi, Xin Yuan, Qingfei Chu, Junjun Jia, Yuanshuai Su, Zhengyi Bao, Juan Lu, Lanjuan Li
Summary: It is discovered that 3-hydroxyanthranilic acid (3-HAA) can exhibit anti-inflammatory activity and regulate the immune system by inhibiting T-cell cytokine secretion and influencing macrophage activity. However, its role in the immunomodulation of hepatocellular carcinoma (HCC) has not been well explored. This study develops an HCC model treated with 3-HAA and utilizes CyTOF and scRNA-seq analyses to define the immune landscape of HCC. The findings show that 3-HAA treatment can suppress tumor growth in the HCC model and alter the cytokine levels in plasma, indicating its potential as a therapeutic target for HCC.
Review
Immunology
Xinyu Gu, Xiao Ma, Chao Chen, Jun Guan, Jing Wang, Shanshan Wu, Haihong Zhu
Summary: RNA modification plays a crucial role in epigenetics at the posttranscriptional level. The m(5)C modification of various types of RNA, such as mRNA, tRNA, rRNA, and lncRNA, affects gene expression, metabolism, and is associated with diseases including cancer. Additionally, m(5)C modifications impact the tumor microenvironment by influencing different immune cell populations and their function.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chen Xue, Qinfan Yao, Xinyu Gu, Qingmiao Shi, Xin Yuan, Qingfei Chu, Zhengyi Bao, Juan Lu, Lanjuan Li
Summary: The JAK-STAT pathway plays a crucial role in cell communication and is associated with various physiological and pathological processes. Drugs targeting this pathway have been developed and approved for clinical treatment of diseases.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Letter
Biochemistry & Molecular Biology
Chen Xue, Xinyu Gu, Qiuxian Zheng, Qingmiao Shi, Xin Yuan, Yuanshuai Su, Junjun Jia, Jianwen Jiang, Juan Lu, Lanjuan Li
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)