Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

(2022) Sarah A. Dick et al.   Science Immunology

Macrophages inhibit and enhance endometriosis depending on their origin

(2021) Chloe Hogg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primordial GATA6 macrophages function as extravascular platelets in sterile injury

(2021) J. Zindel et al.   SCIENCE

Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells

(2021) P. A. Louwe et al.   Nature Communications

Cell barrier function of resident peritoneal macrophages in post-operative adhesions

(2021) Tomoya Ito et al.   Nature Communications

The expanding world of tissue‐resident macrophages

(2021) Stephen J. Jenkins et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cellular basis of omentum activation and expansion revealed by single-cell RNA sequencing using a parabiosis model

(2021) Kazuhiko Ishigaki et al.   Scientific Reports

Resident macrophage-dependent immune cell scaffolds drive anti-bacterial defense in the peritoneal cavity

(2021) Adrián Vega-Pérez et al.   IMMUNITY

LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth

(2021) Nan Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

(2020) Anders Etzerodt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

(2020) Helena Aegerter et al.   NATURE IMMUNOLOGY

Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants

(2020) Lucy Helen Jackson-Jones et al.   IMMUNITY

RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression

(2020) María Casanova-Acebes et al.   Nature Communications

M2-like, dermal macrophages are maintained via IL-4/CCL24–mediated cooperative interaction with eosinophils in cutaneous leishmaniasis

(2020) Sang Hun Lee et al.   Science Immunology

Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

(2020) Sophie Tran et al.   IMMUNITY

Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

(2020) C. C. Bain et al.   Science Immunology

Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1

(2020) Venkatesh Krishnan et al.   Communications Biology

Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity

(2019) Nan Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mesothelial cell CSF1 sustains peritoneal macrophage proliferation

(2019) Stoyan Ivanov et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

(2019) Matthew B. Buechler et al.   IMMUNITY

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

(2019) Rocío Rojo et al.   Nature Communications

The biology of serous cavity macrophages

(2018) Calum C. Bain et al.   CELLULAR IMMUNOLOGY

Csf1r-mApple Transgene Expression and Ligand Binding In Vivo Reveal Dynamics of CSF1R Expression within the Mononuclear Phagocyte System

(2018) Catherine A. Hawley et al.   JOURNAL OF IMMUNOLOGY

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia

(2018) Joseph D. Turner et al.   PLoS Pathogens

Immunological Functions of the Omentum

(2017) Selene Meza-Perez et al.   TRENDS IN IMMUNOLOGY

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

MHC II + resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes

(2016) Ki-Wook Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

(2016) Calum C. Bain et al.   Nature Communications

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis

(2014) Albert Dahdah et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterisation of a Novel Fc Conjugate of Macrophage Colony-stimulating Factor

(2014) Deborah J Gow et al.   MOLECULAR THERAPY

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

Homeostasis in the mononuclear phagocyte system

(2014) Stephen J. Jenkins et al.   TRENDS IN IMMUNOLOGY

Local apoptosis mediates clearance of macrophages from resolving inflammation in mice

(2013) E. L. Gautier et al.   BLOOD

The Parity-Associated Microenvironmental Niche in the Omental Fat Band Is Refractory to Ovarian Cancer Metastasis

(2013) C. A. Cohen et al.   Cancer Prevention Research

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

(2013) Stephen J. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation

(2011) Luke C. Davies et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Two physically, functionally, and developmentally distinct peritoneal macrophage subsets

(2010) E. E. B. Ghosn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymphocytes in the Peritoneum Home to the Omentum and Are Activated by Resident Dendritic Cells

(2009) D. A. Carlow et al.   JOURNAL OF IMMUNOLOGY