CCN2 (Cellular Communication Network Factor 2) Deletion Alters Vascular Integrity and Function Predisposing to Aneurysm Formation

Interleukin 12p40 Deficiency Promotes Abdominal Aortic Aneurysm by Activating CCN2/MMP2 Pathways

(2021) Neekun Sharma et al.   Journal of the American Heart Association

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

(2021) Sandra Rayego-Mateos et al.   CLINICAL SCIENCE

Aneurysm severity is suppressed by deletion of CCN4

(2021) Helen Williams et al.   Journal of Cell Communication and Signaling

Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)–Induced Abdominal Aortic Aneurysm

(2019) Neekun Sharma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Elastic fibers and biomechanics of the aorta: Insights from mouse studies

(2019) Hiromi Yanagisawa et al.   MATRIX BIOLOGY

Update on Clinical Trials of Losartan With and Without β-Blockers to Block Aneurysm Growth in Patients With Marfan Syndrome

(2019) Marion A. Hofmann Bowman et al.   JAMA Cardiology

Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm

(2019) Huimin Yan et al.   Scientific Reports

Caught between a “Rho” and a hard place: are CCN1/CYR61 and CCN2/CTGF the arbiters of microvascular stiffness?

(2019) Brahim Chaqour   Journal of Cell Communication and Signaling

Serum amyloid a protein as a potential biomarker in predicting acute onset and association with in-hospital death in acute aortic dissection

(2019) Yuchen He et al.   BMC Cardiovascular Disorders

Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial

(2019) Michael Mullen et al.   LANCET

Multifaced Roles of the αvβ3 Integrin in Ehlers–Danlos and Arterial Tortuosity Syndromes’ Dermal Fibroblasts

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation

(2018) Sandra Rayego-Mateos et al.   JOURNAL OF PATHOLOGY

Deletion of ACTA2 in mice promotes angiotensin II induced pathogenesis of thoracic aortic aneurysms and dissections

(2018) Jiancheng Cheng et al.   Journal of Thoracic Disease

Fenestrated endovascular aneurysm repair-induced acute kidney injury does not result in chronic renal dysfunction

(2018) S. Keisin Wang et al.   JOURNAL OF VASCULAR SURGERY

The official unified nomenclature adopted by the HGNC calls for the use of the acronyms, CCN1–6, and discontinuation in the use of CYR61, CTGF, NOV and WISP 1–3 respectively

(2018) Bernard Perbal et al.   Journal of Cell Communication and Signaling

Matricellular protein CCN3 mitigates abdominal aortic aneurysm

(2016) Chao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury

(2016) Ole Jørgen Kaasbøll et al.   PLoS One

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions

(2016) Xiaofeng Chen et al.   PLoS One

The C-Terminal Module IV of Connective Tissue Growth Factor, Through EGFR/Nox1 Signaling, Activates the NF-κB Pathway and Proinflammatory Factors in Vascular Smooth Muscle Cells

(2015) Raúl R. Rodrigues-Diez et al.   ANTIOXIDANTS & REDOX SIGNALING

Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation

(2015) N. R. Webb et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Experimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq

(2015) Anto P. Rajkumar et al.   BMC GENOMICS

Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis

(2015) Bram Trachet et al.   CARDIOVASCULAR RESEARCH

CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload

(2015) Magda S.C. Fontes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A deletion in chromosome 6q is associated with human abdominal aortic aneurysm

(2014) Erik Biros et al.   CLINICAL SCIENCE

Connective Tissue Growth Factor Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in Pressure Overload–Induced Heart Failure

(2014) Zoltán Szabó et al.   HYPERTENSION

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

(2014) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

A perspective on anti-CCN2 therapy for chronic kidney disease

(2014) L. L. Falke et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Elevated expression of connective tissue growth factor, osteopontin and increased collagen content in human ascending thoracic aortic aneurysms

(2014) YH Meng et al.   Vascular

Mineralocorticoid Receptor Agonists Induce Mouse Aortic Aneurysm Formation and Rupture in the Presence of High Salt

(2013) Shu Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative stress modulates vascular smooth muscle cell phenotype via CTGF in thoracic aortic aneurysm

(2013) E. Branchetti et al.   CARDIOVASCULAR RESEARCH

Inhibition of connective tissue growth factor suppresses hepatic stellate cell activation in vitro and prevents liver fibrosis in vivo

(2013) Chunqiu Hao et al.   CLINICAL AND EXPERIMENTAL MEDICINE

CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload

(2013) Jørgen Gravning et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Protective effects of selective mineralocorticoid receptor antagonist against aortic aneurysm progression in a novel murine model

(2013) Hirotsugu Kurobe et al.   JOURNAL OF SURGICAL RESEARCH

Connective tissue growth factor (CCN2) in blood vessels

(2013) Markella Ponticos   VASCULAR PHARMACOLOGY

Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes

(2012) Mitsuhiro Hoshijima et al.   FEBS Journal

Knockdown of connective tissue growth factor by plasmid-based short hairpin RNA prevented pulmonary vascular remodeling in cigarette smoke-exposed rats

(2011) Ran Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

S100A8 and S100A9 in Cardiovascular Biology and Disease

(2011) Michelle M. Averill et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury

(2010) M. Shakil Ahmed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice

(2010) Yu Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

CCN3 (NOV) Is a Negative Regulator of CCN2 (CTGF) and a Novel Endogenous Inhibitor of the Fibrotic Pathway in an in Vitro Model of Renal Disease

(2009) Bruce L. Riser et al.   AMERICAN JOURNAL OF PATHOLOGY

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen

(2009) Markella Ponticos et al.   ARTHRITIS AND RHEUMATISM

Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

(2009) Catherine Rush et al.   BMC GENOMICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload

(2009) Anna N. Panek et al.   PLoS One

Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure

(2008) Norimichi Koitabashi et al.   EUROPEAN JOURNAL OF HEART FAILURE