Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

Cross-species considerations in models of neurodevelopmental disorders

(2022) Sally M. Till et al.   TRENDS IN NEUROSCIENCES

Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders

(2021) Jessica A. Jiménez et al.   Journal of Neurodevelopmental Disorders

Defining and Intervening on Cumulative Environmental Neurodevelopmental Risks: Introducing a Complex Systems Approach

(2021) Devon C. Payne-Sturges et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells

(2021) Anna Adhikari et al.   HUMAN MOLECULAR GENETICS

Toward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research

(2021) Alan S. Lewis et al.   eNeuro

Use of mouse models to investigate the contributions of CNVs associated with schizophrenia and autism to disease mechanisms

(2021) Steven E Hyman   CURRENT OPINION IN GENETICS & DEVELOPMENT

Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions

(2021) James T. McCracken et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Excessive laughter-like vocalizations, microcephaly, and translational outcomes in the Ube3a deletion rat model of Angelman Syndrome

(2021) Elizabeth L. Berg et al.   JOURNAL OF NEUROSCIENCE

Recent ultra-rare inherited variants implicate new autism candidate risk genes

(2021) Amy B. Wilfert et al.   NATURE GENETICS

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome

(2021) Elizabeth L. Berg et al.   Molecular Autism

The Lancet Commission on the future of care and clinical research in autism

(2021) Catherine Lord et al.   LANCET

Prevalence and phenotypic impact of rare potentially damaging variants in autism spectrum disorder

(2021) Behrang Mahjani et al.   Molecular Autism

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

(2020) F. Kyle Satterstrom et al.   CELL

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

(2020) Jonathan A. Hollander et al.   NEUROPSYCHOPHARMACOLOGY

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

(2020) E. L. Berg et al.   Translational Psychiatry

Insufficient Evidence for “Autism-Specific” Genes

(2020) Scott M. Myers et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

(2020) Nathalie Percie du Sert et al.   JOURNAL OF PHYSIOLOGY-LONDON

ARRIVE GUIDELINES 2.0

(2020) Wendy Sprague   VETERINARY CLINICAL PATHOLOGY

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

(2020) Nathalie Percie du Sert et al.   PLOS BIOLOGY

Arriving again: 10 years on, ARRIVE 2.0 offers a simplified set of reporting guidelines

(2020) Alla Katsnelson   LAB ANIMAL

Lost in translation: At the crossroads of face validity and translational utility of behavioral assays in animal models for the development of therapeutics

(2020) J.L. Silverman et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants

(2019) F. Kyle Satterstrom et al.   NATURE NEUROSCIENCE

Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration

(2019) Nycole Ashley Copping et al.   EPILEPSY & BEHAVIOR

Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder

(2018) Elizabeth L. Berg et al.   Autism Research

Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders

(2018) Jill L. Silverman et al.   CURRENT OPINION IN NEUROLOGY

Rigor and reproducibility in rodent behavioral research

(2018) Maria Gulinello et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Diagnosis of Autism Spectrum Disorder after Age 5 in Children Evaluated Longitudinally Since Infancy

(2018) Sally Ozonoff et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Animal models for autism in 2017 and the consequential implications to drug discovery

(2017) Kathryn K. Chadman   Expert Opinion on Drug Discovery

A novel SYN1 missense mutation in non-syndromic X-linked intellectual disability affects synaptic vesicle life cycle, clustering and mobility

(2017) Fabrizia C Guarnieri et al.   HUMAN MOLECULAR GENETICS

Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome

(2017) Nycole A Copping et al.   HUMAN MOLECULAR GENETICS

Early brain development in infants at high risk for autism spectrum disorder

(2017) Heather Cody Hazlett et al.   NATURE

Germline Chd8 haploinsufficiency alters brain development in mouse

(2017) Andrea L Gompers et al.   NATURE NEUROSCIENCE

Autism genetics: opportunities and challenges for clinical translation

(2017) Jacob A. S. Vorstman et al.   NATURE REVIEWS GENETICS

Touchscreen learning deficits and normal social approach behavior in the Shank3B model of Phelan–McDermid Syndrome and autism

(2017) Nycole A. Copping et al.   NEUROSCIENCE

Analyzing test batteries in animal models of psychopathology with multivariate analysis of variance (MANOVA): One possible approach to increase external validity

(2017) Yelena Stukalin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

(2017) Randall J. Platt et al.   Cell Reports

Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism

(2017) Jason J. Wolff et al.   Molecular Autism

Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism

(2017) Sameer C. Dhamne et al.   Molecular Autism

Cortical thickness change in autism during early childhood

(2016) Elizabeth Smith et al.   HUMAN BRAIN MAPPING

Prevalence and Characteristics of Autism Spectrum Disorder Among 4-Year-Old Children in the Autism and Developmental Disabilities Monitoring Network

(2016) Deborah L. Christensen et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Does age matter? The impact of rodent age on study outcomes

(2016) Samuel J Jackson et al.   LABORATORY ANIMALS

Men and mice: Relating their ages

(2016) Sulagna Dutta et al.   LIFE SCIENCES

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

(2016) Yuta Katayama et al.   NATURE

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships

(2016) Laura J. Sittig et al.   NEURON

Autism genetics - an overview

(2016) Jiani Yin et al.   PRENATAL DIAGNOSIS

Early communication deficits in theShank1knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context

(2015) A. Özge Sungur et al.   Autism Research

Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder

(2015) Haruhisa Ohta et al.   Autism Research

The side-by-side exploratory test

(2015) Isabel C. Schaefer et al.   BEHAVIOURAL PHARMACOLOGY

Affective communication in rodents

(2015) Markus Wöhr et al.   BEHAVIOURAL PHARMACOLOGY

A Genome-wide Association Study of Autism Using the Simons Simplex Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase Genetic Homogeneity?

(2015) Pauline Chaste et al.   BIOLOGICAL PSYCHIATRY

Engrailed-2(En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior

(2015) Matthieu Genestine et al.   HUMAN MOLECULAR GENETICS

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

(2015) Sara Silva-Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse Social Interaction Test (MoST): a quantitative computer automated analysis of behavior

(2015) Panayotis K. Thanos et al.   JOURNAL OF NEURAL TRANSMISSION

Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits

(2015) H. E. Speed et al.   JOURNAL OF NEUROSCIENCE

GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism

(2015) J L Silverman et al.   NEUROPSYCHOPHARMACOLOGY

Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism

(2015) Jacob Ellegood et al.   Neurotherapeutics

In tribute to Bob Blanchard: Divergent behavioral phenotypes of 16p11.2 deletion mice reared in same-genotype versus mixed-genotype cages

(2015) Mu Yang et al.   PHYSIOLOGY & BEHAVIOR

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

(2015) Malcolm R. Macleod et al.   PLOS BIOLOGY

Experimenter effects on behavioral test scores of eight inbred mouse strains under the influence of ethanol

(2014) Martin Bohlen et al.   BEHAVIOURAL BRAIN RESEARCH

Improving and Accelerating Drug Development for Nervous System Disorders

(2014) Diana E. Pankevich et al.   NEURON

Improving basic and translational science by accounting for litter-to-litter variation in animal models

(2013) Stanley E Lazic et al.   BMC NEUROSCIENCE

Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder

(2013) Mark D. Shen et al.   BRAIN

Affective communication in rodents: ultrasonic vocalizations as a tool for research on emotion and motivation

(2013) Markus Wöhr et al.   CELL AND TISSUE RESEARCH

Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission

(2013) M. Kouser et al.   JOURNAL OF NEUROSCIENCE

PTEN signaling in autism spectrum disorders

(2012) Jing Zhou et al.   CURRENT OPINION IN NEUROBIOLOGY

Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice

(2012) M. Yang et al.   JOURNAL OF NEUROSCIENCE

Sex Differences in the Brain: The Not So Inconvenient Truth

(2012) M. M. McCarthy et al.   JOURNAL OF NEUROSCIENCE

A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism

(2012) P. B. S. Celestino-Soper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

(2012) J. L. Silverman et al.   Science Translational Medicine

Autism genetics: searching for specificity and convergence

(2012) Jamee M Berg et al.   GENOME BIOLOGY

A novel X-linked disorder with developmental delay and autistic features

(2011) Namik Kaya et al.   ANNALS OF NEUROLOGY

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses

(2011) Sarah R. Gilman et al.   NEURON

Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function

(2011) M. Etherton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

“Positive” Results Increase Down the Hierarchy of the Sciences

(2010) Daniele Fanelli   PLoS One

Do Pressures to Publish Increase Scientists' Bias? An Empirical Support from US States Data

(2010) Daniele Fanelli   PLoS One

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Mouse neurexin-1  deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

(2009) M. R. Etherton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel de novo SHANK3 mutation in autistic patients

(2008) Julie Gauthier et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2

(2008) J. Blundell et al.   GENES BRAIN AND BEHAVIOR

Standards for the publication of mouse mutant studies

(2008) W. E. Crusio et al.   GENES BRAIN AND BEHAVIOR

Behavioral Differences among C57BL/6 Substrains: Implications for Transgenic and Knockout Studies

(2008) Camron D. Bryant et al.   JOURNAL OF NEUROGENETICS

Behavioral Phenotyping Strategies for Mutant Mice

(2008) Jacqueline N. Crawley   NEURON

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

(2008) S. Jamain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroanatomy of autism

(2008) David G. Amaral et al.   TRENDS IN NEUROSCIENCES