Roles of vimentin in health and disease

Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex

(2022) Huayin Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Vimentin Intermediate Filaments on the Structure and Dynamics of In Vitro Multicomponent Interpenetrating Cytoskeletal Networks

(2021) Yinan Shen et al.   PHYSICAL REVIEW LETTERS

Reactive astrocytes prevent maladaptive plasticity after ischemic stroke

(2021) Markus Aswendt et al.   PROGRESS IN NEUROBIOLOGY

A dominant vimentin variant causes a rare syndrome with premature aging

(2020) Benjamin Cogné et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Age-dependent Differences in T Cell Responses to Influenza A Virus

(2020) Andrew D Prigge et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Harmful vimentin manifests itself as multiorgan failure

(2020) John E. Eriksson   EUROPEAN JOURNAL OF HUMAN GENETICS

Mechanical and Non‐Mechanical Functions of Filamentous and Non‐Filamentous Vimentin

(2020) Alison E. Patteson et al.   BIOESSAYS

Artemisinins target the intermediate filament protein vimentin for human cytomegalovirus inhibition

(2020) Sujayita Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vimentin Deficiency Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice

(2020) SeoYeon Kim et al.   Diabetes & Metabolism Journal

Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

(2019) A. Vahabikashi et al.   BIOPHYSICAL JOURNAL

The role of GFAP and vimentin in learning and memory

(2019) Ulrika Wilhelmsson et al.   BIOLOGICAL CHEMISTRY

Vimentin is required for normal accumulation of body fat

(2019) Ulrika Wilhelmsson et al.   BIOLOGICAL CHEMISTRY

Intermediate Filaments as Effectors of Cancer Development and Metastasis: A Focus on Keratins, Vimentin, and Nestin

(2019) Pooja Sharma et al.   Cells

IPF and Lung Cancer: Finding Similarities within Differences

(2019) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments

(2019) Jiliang Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes

(2019) Pablo et al.   Cells

Nestin affects fusion pore dynamics in mouse astrocytes

(2019) Eva Lasič et al.   Acta Physiologica

Vimentin protects cells against nuclear rupture and DNA damage during migration

(2019) Alison E. Patteson et al.   JOURNAL OF CELL BIOLOGY

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

(2019) Nicole C. A. van Engeland et al.   Scientific Reports

Astrocyte activation and reactive gliosis—A new target in stroke?

(2018) Milos Pekny et al.   NEUROSCIENCE LETTERS

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation

(2018) Tali Lang et al.   Nature Communications

Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells

(2018) Imran Mohammad et al.   PLOS BIOLOGY

Cytoplasmic Intermediate Filaments in Cell Biology

(2018) Sandrine Etienne-Manneville   Annual Review of Cell and Developmental Biology

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease

(2018) Cameron McDonald-Hyman et al.   JOURNAL OF CLINICAL INVESTIGATION

Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells

(2018) Ulrika Wilhelmsson et al.   CEREBRAL CORTEX

Extracellular vimentin modulates human dendritic cell activation

(2018) Mary Beth Yu et al.   MOLECULAR IMMUNOLOGY

Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice

(2018) Liliana Håversen et al.   Scientific Reports

Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA

(2017) Yaming Jiu et al.   JOURNAL OF CELL SCIENCE

The third wave: Intermediate filaments in the maturing nervous system

(2017) Matthew T.K. Kirkcaldie et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Increased Neuronal Differentiation of Neural Progenitor Cells Derived from Phosphovimentin-Deficient Mice

(2017) Meng Chen et al.   MOLECULAR NEUROBIOLOGY

Selective regulation of Notch ligands during angiogenesis is mediated by vimentin

(2017) Daniel Antfolk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vimentin fibers orient traction stress

(2017) Nancy Costigliola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermediate Filaments and the Regulation of Cell Motility during Regeneration and Wound Healing

(2017) Fang Cheng et al.   Cold Spring Harbor Perspectives in Biology

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

Vimentin knockout results in increased expression of sub-endothelial basement membrane components and carotid stiffness in mice

(2017) Benoit Langlois et al.   Scientific Reports

Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling

(2016) Fang Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermediate Filaments: Structure and Assembly

(2016) Harald Herrmann et al.   Cold Spring Harbor Perspectives in Biology

Lack of vimentin impairs endothelial differentiation of embryonic stem cells

(2016) Liana C. Boraas et al.   Scientific Reports

Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration

(2016) Zhuo Gan et al.   Cell Systems

Vimentin, a Novel NF-κB Regulator, Is Required for Meningitic Escherichia coli K1-Induced Pathogen Invasion and PMN Transmigration across the Blood-Brain Barrier

(2016) Sheng-He Huang et al.   PLoS One

High Vimentin Expression Associated with Lymph Node Metastasis and Predicated a Poor Prognosis in Oral Squamous Cell Carcinoma

(2016) Shuli Liu et al.   Scientific Reports

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function

(2015) Reetta Virtakoivu et al.   CANCER RESEARCH

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks

(2015) Sarah Köster et al.   CURRENT OPINION IN CELL BIOLOGY

Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin

(2015) Kirsten A. Wunderlich et al.   FASEB JOURNAL

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

(2015) Willem Kamphuis et al.   GLIA

Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice

(2015) Hiroki Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency

(2015) Isabell Lebkuechner et al.   JOURNAL OF NEUROCHEMISTRY

Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis

(2015) Paola Bargagna-Mohan et al.   PLoS One

Vimentin regulates activation of the NLRP3 inflammasome

(2015) Gimena dos Santos et al.   Nature Communications

Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation

(2015) Ching-Yi Liu et al.   Oncotarget

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

(2015) Yaming Jiu et al.   Cell Reports

Probing the Stochastic, Motor-Driven Properties of the Cytoplasm Using Force Spectrum Microscopy

(2014) Ming Guo et al.   CELL

Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis

(2014) Mihoko Sutoh Yoneyama et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Beneficial effects of gfap/vimentin reactive astrocytes for axonal remodeling and motor behavioral recovery in mice after stroke

(2014) Zhongwu Liu et al.   GLIA

Vimentin as an Integral Regulator of Cell Adhesion and Endothelial Sprouting

(2014) Jui M. Dave et al.   MICROCIRCULATION

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

On the Formation of Lipid Droplets in Human Adipocytes: The Organization of the Perilipin–Vimentin Cortex

(2014) Hans Heid et al.   PLoS One

Oncogenes induce a vimentin filament collapse mediated by HDAC6 that is linked to cell stiffness

(2014) L.-S. Z. Rathje et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Vimentin Intermediate Filaments in the Progression of Lung Cancer

(2013) Martha E Kidd et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanosensing through focal adhesion-anchored intermediate filaments

(2013) Martin Gregor et al.   FASEB JOURNAL

Intermediate filaments are important for astrocyte response to oxidative stress induced by oxygen–glucose deprivation and reperfusion

(2013) Yolanda de Pablo et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Defect of Mitotic Vimentin Phosphorylation Causes Microophthalmia and Cataract via Aneuploidy and Senescence in Lens Epithelial Cells

(2013) Makoto Matsuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas

(2013) Maryline Dauphin et al.   LUNG CANCER

Variable Metastatic Potentials Correlate with Differential Plectin and Vimentin Expression in Syngeneic Androgen Independent Prostate Cancer Cells

(2013) Tanya C. Burch et al.   PLoS One

Axonal Regeneration after Sciatic Nerve Lesion Is Delayed but Complete in GFAP- and Vimentin-Deficient Mice

(2013) Alexander Berg et al.   PLoS One

Murine Colitis is Mediated by Vimentin

(2013) Nirit Mor-Vaknin et al.   Scientific Reports

The inflammasome in lung diseases

(2012) Gimena dos Santos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Vimentin regulates peripheral nerve myelination

(2012) D. Triolo et al.   DEVELOPMENT

Ablation of Vimentin Results in Defective Steroidogenesis

(2012) Wen-Jun Shen et al.   ENDOCRINOLOGY

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

(2012) Andrew W. Kraft et al.   FASEB JOURNAL

IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments

(2012) Nina Vardjan et al.   Journal of Neuroinflammation

Withaferin A Alters Intermediate Filament Organization, Cell Shape and Behavior

(2012) Boris Grin et al.   PLoS One

Astrocytes Negatively Regulate Neurogenesis Through the Jagged1-Mediated Notch Pathway

(2012) Ulrika Wilhelmsson et al.   STEM CELLS

Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis

(2011) Cecilia Marmai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells

(2011) Micah R. Rogel et al.   FASEB JOURNAL

Corneal Antifibrotic Switch Identified in Genetic and Pharmacological Deficiency of Vimentin

(2011) Paola Bargagna-Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into intermediate filament regulation from development to ageing

(2011) C. L. Hyder et al.   JOURNAL OF CELL SCIENCE

The Role of Attenuated Astrocyte Activation in Infantile Neuronal Ceroid Lipofuscinosis

(2011) S. L. Macauley et al.   JOURNAL OF NEUROSCIENCE

A Novel Role of Vimentin Filaments: Binding and Stabilization of Collagen mRNAs

(2011) A. A. Challa et al.   MOLECULAR AND CELLULAR BIOLOGY

Vimentin expression influences flow dependent VASP phosphorylation and regulates cell migration and proliferation

(2010) Natalie Lund et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

Reactive glial cells: increased stiffness correlates with increased intermediate filament expression

(2010) Yun-Bi Lu et al.   FASEB JOURNAL

Intermediate filaments attenuate stimulation-dependent mobility of endosomes/lysosomes in astrocytes

(2010) Maja Potokar et al.   GLIA

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

(2010) Marie Schoumacher et al.   JOURNAL OF CELL BIOLOGY

Vimentin Is a Functional Partner of Hormone Sensitive Lipase And Facilitates Lipolysis

(2010) Wen-Jun Shen et al.   JOURNAL OF PROTEOME RESEARCH

Vimentin is a novel AKT1 target mediating motility and invasion

(2010) Q-S Zhu et al.   ONCOGENE

Attenuation of Reactive Gliosis Does Not Affect Infarct Volume in Neonatal Hypoxic-Ischemic Brain Injury in Mice

(2010) Katarina Järlestedt et al.   PLoS One

Leukocyte transmigration is modulated by chemokine-mediated PI3Kγ-dependent phosphorylation of vimentin

(2009) Laura Barberis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dominant cataract formation in association with a vimentin assembly disrupting mutation

(2009) M. Muller et al.   HUMAN MOLECULAR GENETICS

Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments

(2009) Zhao Qin et al.   PLoS One

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species

(2008) Hideki Sumimoto   FEBS Journal

Providing cellular signposts - Post-translational modifications of intermediate filaments

(2008) Claire L. Hyder et al.   FEBS LETTERS

Intermediate filaments regulate astrocyte motility

(2003) Eugene A. Lepekhin et al.   JOURNAL OF NEUROCHEMISTRY