Impaired reciprocal regulation between SIRT6 and TGF‐β signaling in fatty liver

TGF-β signaling in Liver, Pancreas, and Gastrointestinal Diseases and Cancer

(2021) Nancy R. Gough et al.   GASTROENTEROLOGY

Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

(2021) Oriol Juanola et al.   International Journal of Environmental Research and Public Health

β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development

(2021) Shuyun Rao et al.   Science Translational Medicine

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice

(2020) Franziska Wandrer et al.   Cell Death & Disease

Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cells

(2020) Jinhang Zhang et al.   HEPATOLOGY

A single cell atlas of the human liver tumor microenvironment

(2020) Hassan Massalha et al.   Molecular Systems Biology

Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis

(2020) Jonghwa Kim et al.   Scientific Reports

The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking β-catenin target gene expression

(2019) Juan Cai et al.   KIDNEY INTERNATIONAL

SIRT6, a Mammalian deacylase with multitasking abilities

(2019) Andrew R Chang et al.   PHYSIOLOGICAL REVIEWS

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice

(2019) Sangeeta Maity et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

(2019) Shoshana Naiman et al.   Cell Reports

Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway

(2018) Jian Chen et al.   GASTROENTEROLOGY

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

(2018) Thomas G. Bird et al.   Science Translational Medicine

Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor

(2017) Sun-O Ka et al.   FASEB JOURNAL

IL6-mediated inflammatory loop reprograms normal to epithelial-mesenchymal transition+ metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta-deficient β2-spectrin+/− mice

(2017) Abhisek Mitra et al.   HEPATOLOGY

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Loss of KLF4 and consequential downregulation of Smad7 exacerbate oncogenic TGF-β signaling in and promote progression of hepatocellular carcinoma

(2017) H Sun et al.   ONCOGENE

Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability

(2016) Jian Chen et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage

(2016) Hye Jung Baek et al.   International Journal of Biological Sciences

TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome

(2016) Jian Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

(2016) Fengyun Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

(2015) Jason G. Anderson et al.   Molecular Metabolism

Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice

(2013) Ling Yang et al.   HEPATOLOGY

Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients

(2013) Jens U. Marquardt et al.   HEPATOLOGY

Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells

(2013) Chia-Lin Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

Multiple Regulatory Layers of SREBP1/2 by SIRT6

(2013) Sivan Elhanati et al.   Cell Reports

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization

(2012) Jesse D. Ziebarth et al.   NUCLEIC ACIDS RESEARCH

Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

(2012) Alicia Lundby et al.   Cell Reports

Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet

(2011) C. K. Tan et al.   DIABETES

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/−Mice: A Role of Lipid Mobilization and Inflammation

(2010) Fen Xu et al.   ENDOCRINOLOGY

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

(2010) Bhaskar Ponugoti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE