Tear and ocular surface disease biomarkers: A diagnostic and clinical perspective for ocular allergies and dry eye disease

Pathophysiologic role of Interleukin-33/ST2 in Sjögren's syndrome

(2021) Muhammad S. Soyfoo et al.   AUTOIMMUNITY REVIEWS

Tear N‐ glycomics in vernal and atopic keratoconjunctivitis

(2021) Angela Messina et al.   ALLERGY

Age‐related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity

(2021) Jeremias G. Galletti et al.   IMMUNOLOGY

The ocular surface immune system through the eyes of aging

(2021) Jeremias G. Galletti et al.   Ocular Surface

Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles

(2021) Jiuk Jang et al.   Science Advances

Alterations in Mucin-Associated Gene Expression on the Ocular Surface in Active and Stable Stages of Atopic and Vernal Keratoconjunctivitis

(2021) Mariko Horinaka et al.   Journal of Ophthalmology

Potential Biomarkers for Allergic Conjunctival Diseases

(2020) Neeta Roy et al.   Eye & Contact Lens-Science and Clinical Practice

Combination of Two Rapid Ophthalmic Test Kits for Improved Diagnosis in Cases of Severe Binocular Conjunctivitis

(2020) Asako Kodama et al.   Diagnostics

Evaluation of Tear Protein Markers in Dry Eye Disease with Different LT-alpha Expression Levels

(2020) Haiyan Chen et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Clinical and tear cytokine profiles after advanced surface ablation refractive surgery: A six-month follow-up

(2020) María J. González-García et al.   EXPERIMENTAL EYE RESEARCH

Simplified Classification of Tear Film Break-Up Patterns and Their Clinicopathological Correlations in Patients With Dry Eye Disease

(2020) Hee Dong Eom et al.   Eye & Contact Lens-Science and Clinical Practice

Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis

(2020) Matilde Roda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Japanese guidelines for allergic conjunctival diseases 2020

(2020) Dai Miyazaki et al.   ALLERGOLOGY INTERNATIONAL

Detection of Tear Components Using Matrix-Assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry for Rapid Dry Eye Diagnosis

(2020) Ting Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Importance of tear volume for positivity of tear matrix metalloproteinase-9 immunoassay

(2020) Jong Hwa Jun et al.   PLoS One

Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases

(2020) Jun Shoji   ALLERGOLOGY INTERNATIONAL

Matrix metalloproteinase 9 positivity predicts long term decreased tear production

(2020) Matias Soifer et al.   Ocular Surface

Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives

(2020) Sherif A. Gaballa et al.   Drug Delivery and Translational Research

Defining Dry Eye from a Clinical Perspective

(2020) Kazuo Tsubota et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis

(2020) Georgi A. Georgiev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic analysis of tear fluid reveals disease-specific patterns in patients with Parkinson's disease – A pilot study

(2019) Matthias Boerger et al.   PARKINSONISM & RELATED DISORDERS

Age-associated changes in human tear proteome

(2019) Janika Nättinen et al.   Clinical Proteomics

Tear Proteases and Protease Inhibitors

(2019) Runzhong Fu et al.   Eye & Contact Lens-Science and Clinical Practice

Investigation of Oligoclonal IgG Bands in Tear Fluid of Multiple Sclerosis Patients

(2019) Martin W. Hümmert et al.   Frontiers in Immunology

Relationship between tear eotaxin-2 and MMP-9 with ocular allergy and corneal topography in keratoconus patients

(2019) Melek Mutlu et al.   INTERNATIONAL OPHTHALMOLOGY

Ocular mucins in dry eye disease

(2019) Céline Portal et al.   EXPERIMENTAL EYE RESEARCH

A New Perspective on Dry Eye Classification

(2019) Kazuo Tsubota et al.   Eye & Contact Lens-Science and Clinical Practice

IgE Ratio in Tears: A Predictive Tool of Ocular Allergic Inflammation

(2019) J. Neil et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Galectin-3: role in ocular allergy and potential as a predictive biomarker

(2018) Frans Eberth Costa Andrade et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

NGF and iNOS Changes in Tears from Video Display Terminal Workers

(2018) Magdalena Cortes et al.   CURRENT EYE RESEARCH

The analysis of human conjunctival epithelium proteome in ocular surface diseases using impression cytology and 2D-DIGE

(2018) Javier Soria et al.   EXPERIMENTAL EYE RESEARCH

Correlation of interleukin-33 with Th cytokines and clinical severity of dry eye disease

(2018) Guoping Luo et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

Tear inflammatory mediators and protein in eyes of post allogenic hematopoeitic stem cell transplant patients

(2018) Sridevi Nair et al.   Ocular Surface

Severity, therapeutic, and activity tear biomarkers in dry eye disease: An analysis from a phase III clinical trial

(2018) José Pinto-Fraga et al.   Ocular Surface

Conjunctival MUC5AC+ goblet cell index: relationship with corneal nerves and dry eye

(2018) Cecilia Chao et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

A novel and innovative paper-based analytical device for assessing tear lactoferrin of dry eye patients

(2018) Hideki Sonobe et al.   Ocular Surface

Tear Luminex Analysis in Dry Eye Patients

(2018) Hailan Zhao et al.   MEDICAL SCIENCE MONITOR

Conjunctival Inflammatory Gene Expression Profiling in Dry Eye Disease: Correlations With HLA-DRA and HLA-DRB1

(2018) Karima Kessal et al.   Frontiers in Immunology

Proteomic analysis of tears following acupuncture treatment for menopausal dry eye disease by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry

(2017) Qingyu Liu et al.   International Journal of Nanomedicine

TFOS DEWS II Tear Film Report

(2017) Mark D.P. Willcox et al.   Ocular Surface

TFOS DEWS II pathophysiology report

(2017) Anthony J. Bron et al.   Ocular Surface

New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society

(2017) Kazuo Tsubota et al.   Ocular Surface

TFOS DEWS II pain and sensation report

(2017) Carlos Belmonte et al.   Ocular Surface

TFOS DEWS II Diagnostic Methodology report

(2017) James S. Wolffsohn et al.   Ocular Surface

TFOS DEWS II Definition and Classification Report

(2017) Jennifer P. Craig et al.   Ocular Surface

Cystatin S—a candidate biomarker for severity of submandibular gland involvement in Sjögren’s syndrome

(2017) Daniela Martini et al.   RHEUMATOLOGY

Histamine H 1 and H 4 receptor expression on the ocular surface of patients with chronic allergic conjunctival diseases

(2017) Noriko Inada et al.   ALLERGOLOGY INTERNATIONAL

Evaluation of commonly used tear sampling methods and their relevance in subsequent biochemical analysis

(2017) Aniko Rentka et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Analysis of Th17-associated cytokines and clinical correlations in patients with dry eye disease

(2017) Rongjun Liu et al.   PLoS One

Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexed-microarray biomarker validation

(2017) Javier Soria et al.   Scientific Reports

Conjunctival allergen provocation test : guidelines for daily practice

(2016) J.-L. Fauquert et al.   ALLERGY

Clinical Usefulness of Simultaneous Measurement of the Tear Levels of CCL17, CCL24, and IL-16 for the Biomarkers of Allergic Conjunctival Disorders

(2016) Jun Shoji et al.   CURRENT EYE RESEARCH

The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases

(2016) Hiroshi Fujishima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Versus Negative Patients

(2016) Nicole L. Lanza et al.   Ocular Surface

Matrix Metalloproteinase 9 Testing in Dry Eye Disease Using a Commercially Available Point-of-Care Immunoassay

(2016) Elisabeth M. Messmer et al.   OPHTHALMOLOGY

Contact Lens-Induced Discomfort and Protein Changes in Tears

(2016) Simin Masoudi et al.   OPTOMETRY AND VISION SCIENCE

Clinical Severity and Tear Biomarkers, Eosinophil Cationic Protein and CCL23, in Chronic Allergic Conjunctival Diseases

(2016) Maki Shoji et al.   Seminars in Ophthalmology

Clinical Usefulness of Monitoring Expression Levels ofCCL24(Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis

(2016) Yukiko Shiraki et al.   Journal of Ophthalmology

High Levels of 17β-Estradiol Are Associated with Increased Matrix Metalloproteinase-2 and Metalloproteinase-9 Activity in Tears of Postmenopausal Women with Dry Eye

(2016) Guanglin Shen et al.   Journal of Ophthalmology

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine

(2016) Suzanne Hagan et al.   EPMA Journal

Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients

(2016) Natarajan Perumal et al.   Scientific Reports

Distance-Based Tear Lactoferrin Assay on Microfluidic Paper Device Using Interfacial Interactions on Surface-Modified Cellulose

(2015) Kentaro Yamada et al.   ACS Applied Materials & Interfaces

Evaluation of point-of-care test for elevated tear matrix metalloproteinase 9 in post-LASIK dry eyes

(2015) Tommy C Y Chan et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Correlation of Tear Film Osmolarity and 2 Different MMP-9 Tests With Common Dry Eye Tests in a Cohort of Non–Dry Eye Patients

(2015) Marc Schargus et al.   CORNEA

Oxidative stress parameters and serum magnesium levels in patients with seasonal allergic conjunctivitis

(2015) Zeynep Dadaci et al.   Cutaneous and Ocular Toxicology

Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification

(2015) Mikel Azkargorta et al.   JOURNAL OF PROTEOME RESEARCH

Microarray-based IgE detection in tears of patients with vernal keratoconjunctivitis

(2015) Andrea Leonardi et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

An antibody-free microfluidic paper-based analytical device for the determination of tear fluid lactoferrin by fluorescence sensitization of Tb3+

(2014) Kentaro Yamada et al.   ANALYST

Cytoprotective Effect of Lacritin on Human Corneal Epithelial Cells Exposed to Benzalkonium ChlorideIn Vitro

(2014) Mary M. Feng et al.   CURRENT EYE RESEARCH

T helper subsets in allergic eye disease

(2014) Nancy J. Reyes et al.   Current Opinion in Allergy and Clinical Immunology

Glycomic characterization of basal tears and changes with diabetes and diabetic retinopathy

(2014) Terry Nguyen-Khuong et al.   GLYCOBIOLOGY

Total IgE and eotaxin (CCL11) contents in tears of patients suffering from seasonal allergic conjunctivitis

(2014) Simone Eperon et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Mass spectrometry based biomarker discovery, verification, and validation - Quality assurance and control of protein biomarker assays

(2014) Carol E. Parker et al.   Molecular Oncology

Tear proteomic analysis of Sjögren syndrome patients with dry eye syndrome by two-dimensional-nano-liquid chromatography coupled with tandem mass spectrometry

(2014) Bing Li et al.   Scientific Reports

Alteration of Tear Mucin 5AC in Office Workers Using Visual Display Terminals

(2014) Yuichi Uchino et al.   JAMA Ophthalmology

Identification of human tear fluid biomarkers in vernal keratoconjunctivitis using iTRAQ quantitative proteomics

(2013) A. Leonardi et al.   ALLERGY

Analysis of Tear Cytokines and Clinical Correlations in Sjögren Syndrome Dry Eye Patients and Non–Sjögren Syndrome Dry Eye Patients

(2013) Sang Yeop Lee et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Analysis of the Correlations of Mucins, Inflammatory Markers, and Clinical Tests in Dry Eye

(2013) Jianan Zhang et al.   CORNEA

Adaptation of Impression Cytology to Enable Conjunctival Surface Cell Transcriptome Analysis

(2013) John L. Bradley et al.   CURRENT EYE RESEARCH

Zinc Finger Protein in Severe Dry Eye Syndrome

(2013) Seung Hoon Lee et al.   CURRENT EYE RESEARCH

Allergy and allergic mediators in tears

(2013) Andrea Leonardi   EXPERIMENTAL EYE RESEARCH

Lacritin Rescues Stressed Epithelia via Rapid Forkhead Box O3 (FOXO3)-associated Autophagy That Restores Metabolism

(2013) Ningning Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S100A Proteins as Molecular Targets in the Ocular Surface Inflammatory Diseases

(2013) Louis Tong et al.   Ocular Surface

Sensitivity and Specificity of a Point-of-Care Matrix Metalloproteinase 9 Immunoassay for Diagnosing Inflammation Related to Dry Eye

(2013) Robert Sambursky et al.   JAMA Ophthalmology

Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface

(2012) A. Leonardi et al.   ALLERGY

IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis

(2012) Tais H Wakamatsu et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Expression of CCR5 and Its Ligands CCL3, -4, and -5 in the Tear Film and Ocular Surface of Patients with Dry Eye Disease

(2012) Won Choi et al.   CURRENT EYE RESEARCH

Relation Between Total Tear IgE and Severity of Acute Seasonal Allergic Conjunctivitis

(2012) Tatsuya Mimura et al.   CURRENT EYE RESEARCH

In-depth analysis of the human tear proteome

(2012) Lei Zhou et al.   Journal of Proteomics

Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction

(2012) J. Soria et al.   Journal of Proteomics

Alterations of Tear Neuromediators in Dry Eye Disease

(2011) Alessandro Lambiase   ARCHIVES OF OPHTHALMOLOGY

Comparison of tear proteins between healthy and early diabetic retinopathy patients

(2011) Hyun-Jung Kim et al.   CLINICAL BIOCHEMISTRY

Anatomy and physiology of the cornea

(2011) Derek W. DelMonte et al.   JOURNAL OF CATARACT AND REFRACTIVE SURGERY

Characterization of The Human Tear Metabolome by LC–MS/MS

(2011) Liyan Chen et al.   JOURNAL OF PROTEOME RESEARCH

A review of non-pharmacological and pharmacological management of seasonal and perennial allergic conjunctivitis

(2011) Paramdeep S. Bilkhu et al.   Contact Lens & Anterior Eye

Association of tear proteins with Meibomian gland disease and dry eye symptoms

(2010) L. Tong et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Atopic keratoconjunctivitis and atopic dermatitis

(2010) Stefano Guglielmetti et al.   Current Opinion in Allergy and Clinical Immunology

Tear proteomics in evaporative dry eye disease

(2010) P Versura et al.   EYE

Atopic Dermatitis and Keratoconjunctivitis

(2010) Brett Bielory et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients

(2009) A. Leonardi et al.   ALLERGY

Analysis of Inflammatory Cytokines in the Tears of Dry Eye Patients

(2009) Morgan L Massingale et al.   CORNEA

Mass Spectrometry-Based Proteomic Analyses in Contact Lens-Related Dry Eye

(2009) Jason J Nichols et al.   CORNEA

Elevated Nerve Growth Factor in Dry Eye Associated With Established Contact Lens Wear

(2009) Qiong Liu et al.   Eye & Contact Lens-Science and Clinical Practice

Evaluation of eotaxin-1, -2, and -3 protein production and messenger RNA expression in patients with vernal keratoconjunctivitis

(2009) Jun Shoji et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Eosinophil Cationic Protein (ECP) Is Processed during Secretion

(2009) C. Woschnagg et al.   JOURNAL OF IMMUNOLOGY

Quantitative Analysis of N-Linked Glycoproteins in Tear Fluid of Climatic Droplet Keratopathy by Glycopeptide Capture and iTRAQ†

(2009) Lei Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Identification of Tear Fluid Biomarkers in Dry Eye Syndrome Using iTRAQ Quantitative Proteomics

(2009) Lei Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Role of Th17 cells in the immunopathogenesis of dry eye disease

(2009) S K Chauhan et al.   Mucosal Immunology

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Evaluation of Total IgE in Tears of Patients with Allergic Conjunctivitis Disease Using a Novel Application of the Immunochromatography Method

(2009) Noriko Inada et al.   ALLERGOLOGY INTERNATIONAL

Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis

(2008) M. Dogru et al.   ALLERGY

Tear Cytokine Profiles in Dysfunctional Tear Syndrome

(2008) Helene Lam et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Lacritin and other new proteins of the lacrimal functional unit

(2008) Robert L. McKown et al.   EXPERIMENTAL EYE RESEARCH

German register for glaucoma patients with dry eye. I. Basic outcome with respect to dry eye

(2008) Carl Erb et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Inflammatory Markers in the Tears of Patients with Ocular Surface Disease

(2008) Arantxa Acera et al.   OPHTHALMIC RESEARCH

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles for IL-13 and IL-4 via IL-13 receptor  1 and the type II IL-4 receptor in asthma pathogenesis

(2008) A. Munitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA