Lacritin Rescues Stressed Epithelia via Rapid Forkhead Box O3 (FOXO3)-associated Autophagy That Restores Metabolism

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

(2016) J. Julie Wu et al.   Aging-US

Targeting of Heparanase-modified Syndecan-1 by Prosecretory Mitogen Lacritin Requires Conserved Core GAGAL plus Heparan and Chondroitin Sulfate as a Novel Hybrid Binding Site That Enhances Selectivity

(2013) Yinghui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

(2012) Rohit Anthony Sinha et al.   JOURNAL OF CLINICAL INVESTIGATION

Ocular surface immunity: Homeostatic mechanisms and their disruption in dry eye disease

(2012) Stefano Barabino et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Neuroendocrine regulation of autophagy by leptin

(2011) Shoaib Ahmad Malik et al.   CELL CYCLE

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

(2011) Susanna Campesan et al.   CURRENT BIOLOGY

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Characterization of The Human Tear Metabolome by LC–MS/MS

(2011) Liyan Chen et al.   JOURNAL OF PROTEOME RESEARCH

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Evaluation of the Transforming Growth Factor-β Activity in Normal and Dry Eye Human Tears by CCL-185 Cell Bioassay

(2010) Xiaofen Zheng et al.   CORNEA

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

(2010) Marta M. Lipinski et al.   DEVELOPMENTAL CELL

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

(2009) Carol A. Mercer et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

Mass Spectrometry-Based Proteomic Analyses in Contact Lens-Related Dry Eye

(2009) Jason J Nichols et al.   CORNEA

The Effect of Meibomian Lipids and Tear Proteins on Evaporation Rate under ControlledIn VitroConditions

(2009) George Henryk Herok et al.   CURRENT EYE RESEARCH

Autophagy: links with the proteasome

(2009) Trond Lamark et al.   CURRENT OPINION IN CELL BIOLOGY

Identification of Tear Fluid Biomarkers in Dry Eye Syndrome Using iTRAQ Quantitative Proteomics

(2009) Lei Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Tear Cytokine Profiles in Dysfunctional Tear Syndrome

(2008) Helene Lam et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

A high confidence, manually validated human blood plasma protein reference set

(2008) Susann Schenk et al.   BMC Medical Genomics

TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3β

(2008) K Yoon et al.   CELL DEATH AND DIFFERENTIATION

Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs

(2008) Hong Qi et al.   EXPERIMENTAL EYE RESEARCH

Lacritin and other new proteins of the lacrimal functional unit

(2008) Robert L. McKown et al.   EXPERIMENTAL EYE RESEARCH

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

The Survival-promoting Peptide Y-P30 Enhances Binding of Pleiotrophin to Syndecan-2 and -3 and Supports Its Neuritogenic Activity

(2008) Peter Landgraf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

(2008) Steffen Runge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription factor FOXO3a controls the persistence of memory CD4+ T cells during HIV infection

(2008) Julien van Grevenynghe et al.   NATURE MEDICINE

Dry Eye and Designer Ophthalmics

(2008) Gordon W. Laurie et al.   OPTOMETRY AND VISION SCIENCE

Focus on Molecules: Lacritin

(2007) Peisong Ma et al.   EXPERIMENTAL EYE RESEARCH