Gamma delta (γδ) T cells in cancer immunotherapy; where it comes from, where it will go?

Clinicopathological Correlates of γδ T Cell Infiltration in Triple-Negative Breast Cancer

(2021) Florence Boissière-Michot et al.   Cancers

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

(2020) S. Depil et al.   NATURE REVIEWS DRUG DISCOVERY

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

(2020) Marc Rigau et al.   SCIENCE

ImmuCellAI: A Unique Method for Comprehensive T‐Cell Subsets Abundance Prediction and its Application in Cancer Immunotherapy

(2020) Ya‐Ru Miao et al.   Advanced Science

γδ T Cells: The Ideal Tool for Cancer Immunotherapy

(2020) Mahboubeh Yazdanifar et al.   Cells

The landscape of immune cell infiltration and its clinical implications of pancreatic ductal adenocarcinoma

(2020) Caiming Xu et al.   Journal of Advanced Research

High Abundance of Intratumoral γδ T Cells Favors a Better Prognosis in Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis

(2020) Huanzi Lu et al.   Frontiers in Immunology

Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells

(2019) Biagio Di Lorenzo et al.   Cancer Immunology Research

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

(2019) Chengcheng Jin et al.   CELL

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell

(2019) Jieming Zeng et al.   PLoS One

NKT cells co-expressing a GD2-specific chimeric antigen receptor and IL-15 show enhanced in vivo persistence and antitumor activity against neuroblastoma

(2019) Xin Xu et al.   CLINICAL CANCER RESEARCH

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

(2019) Zsolt Sebestyen et al.   NATURE REVIEWS DRUG DISCOVERY

Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells

(2019) Vinicia A. Polito et al.   Frontiers in Immunology

Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation

(2018) Anna Capsomidis et al.   MOLECULAR THERAPY

Human αβ and γδ T Cells in Skin Immunity and Disease

(2018) Michelle S. Cruz et al.   Frontiers in Immunology

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

(2018) André E. Simões et al.   Frontiers in Immunology

Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer

(2018) Rohtesh S. Mehta et al.   Frontiers in Immunology

Tribody [(HER2)2xCD16] Is More Effective Than Trastuzumab in Enhancing γδ T Cell and Natural Killer Cell Cytotoxicity Against HER2-Expressing Cancer Cells

(2018) Hans H. Oberg et al.   Frontiers in Immunology

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

(2018) Marco Ruella et al.   NATURE MEDICINE

Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia

(2018) Elena J. Orlando et al.   NATURE MEDICINE

Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting

(2018) Antonia Rotolo et al.   CANCER CELL

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

(2018) Matthew M. Gubin et al.   CELL

Universal CARs, universal T cells, and universal CAR T cells

(2018) Juanjuan Zhao et al.   Journal of Hematology & Oncology

PD-1 signaling modulates interferon-γ production by Gamma Delta (γδ) T-Cells in response to leukemia

(2018) Timm Hoeres et al.   OncoImmunology

Allogeneic CAR-T Cells: More than Ease of Access?

(2018) Charlotte Graham et al.   Cells

Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation

(2017) Dorien Van hede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Squamous Cell Tumors Recruit γδ T Cells Producing either IL17 or IFNγ Depending on the Tumor Stage

(2017) Elena Lo Presti et al.   Cancer Immunology Research

Tumor-infiltrating γδT cells predict prognosis and adjuvant chemotherapeutic benefit in patients with gastric cancer

(2017) Jieti Wang et al.   OncoImmunology

Tumor-infiltrating CD39+ γδTregs are novel immunosuppressive T cells in human colorectal cancer

(2017) Guoming Hu et al.   OncoImmunology

Assessment of tumor-infiltrating TCRVγ9Vδ2 γδ lymphocyte abundance by deconvolution of human cancers microarrays

(2017) Marie Tosolini et al.   OncoImmunology

Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer

(2017) S. Meraviglia et al.   OncoImmunology

A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells

(2017) Renée C. G. de Bruin et al.   OncoImmunology

Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy

(2016) Hamid Reza Mirzaei et al.   CANCER LETTERS

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

(2016) A. R. Almeida et al.   CLINICAL CANCER RESEARCH

Proportions of blood-borne Vδ1+ and Vδ2+ T-cells are associated with overall survival of melanoma patients treated with ipilimumab

(2016) Kilian Wistuba-Hamprecht et al.   EUROPEAN JOURNAL OF CANCER

IL17 producing γδT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients

(2016) Rushikesh Sudam Patil et al.   INTERNATIONAL JOURNAL OF CANCER

Regulatory and effector functions of gamma-delta (γδ) T cells and their therapeutic potential in adoptive cellular therapy for cancer

(2016) Sourav Paul et al.   INTERNATIONAL JOURNAL OF CANCER

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Human Vδ2 T cells are a major source of interleukin-9

(2016) Christian Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFN -Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2-Mediated Inhibition of Antitumor CTL Responses

(2016) F. S. Basingab et al.   Cancer Immunology Research

Human gamma delta T cells: Evolution and ligand recognition

(2015) Erin J. Adams et al.   CELLULAR IMMUNOLOGY

Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy

(2015) L. Zhai et al.   CLINICAL CANCER RESEARCH

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma

(2015) Benjamin H. Beck et al.   PLoS One

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

(2015) A. J. Gunderson et al.   Cancer Discovery

Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity

(2015) Daniel Gonnermann et al.   OncoImmunology

Anergic bone marrow Vγ9Vδ2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma

(2015) Barbara Castella et al.   OncoImmunology

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia

(2014) Florencia McAllister et al.   CANCER CELL

IL-17A Produced by    T Cells Promotes Tumor Growth in Hepatocellular Carcinoma

(2014) S. Ma et al.   CANCER RESEARCH

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

(2014) Deepak Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

(2014) Pin Wu et al.   IMMUNITY

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

Protective Immunosurveillance and Therapeutic Antitumor Activity of γδ T Cells Demonstrated in a Mouse Model of Prostate Cancer

(2014) Zhiyong Liu et al.   JOURNAL OF IMMUNOLOGY

Definition of APC Presentation of Phosphoantigen (E)-4-Hydroxy-3-methyl-but-2-enyl Pyrophosphate to V 2V 2 TCR

(2014) H. Wei et al.   JOURNAL OF IMMUNOLOGY

Murine CD27(-) V 6(+)    T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

(2014) M. Rei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraperitoneal injection of in vitro expanded Vγ9Vδ2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer

(2014) Ikuo Wada et al.   Cancer Medicine

Specific Recruitment of    Regulatory T Cells in Human Breast Cancer

(2013) J. Ye et al.   CANCER RESEARCH

High density of IL-17-producing cells is associated with improved prognosis for advanced epithelial ovarian cancer

(2013) Chunyan Lan et al.   CELL AND TISSUE RESEARCH

Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells

(2013) Christian Peters et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V 3 T Cells

(2013) B. A. Mangan et al.   JOURNAL OF IMMUNOLOGY

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic    T Lymphocytes to Tumor Beds

(2013) T. Lanca et al.   JOURNAL OF IMMUNOLOGY

Butyrophilin 3A1 Plays an Essential Role in Prenyl Pyrophosphate Stimulation of Human V 2V 2 T Cells

(2013) H. Wang et al.   JOURNAL OF IMMUNOLOGY

A Dose-Escalation Study of Recombinant Human Interleukin-18 in Combination With Rituximab in Patients With Non-Hodgkin Lymphoma

(2013) Michael J. Robertson et al.   JOURNAL OF IMMUNOTHERAPY

Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor

(2013) Drew C Deniger et al.   MOLECULAR THERAPY

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy

(2013) Maria Themeli et al.   NATURE BIOTECHNOLOGY

Engineered Drug Resistant γδ T Cells Kill Glioblastoma Cell Lines during a Chemotherapy Challenge: A Strategy for Combining Chemo- and Immunotherapy

(2013) Lawrence S. Lamb et al.   PLoS One

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

(2013) Kelly Hudspeth et al.   Frontiers in Immunology

Tumor cell recognition by γδ T lymphocytes

(2013) Daniel V. Correia et al.   OncoImmunology

Long-Term Effects of Amino-Bisphosphonates on Circulating γδ T Cells

(2012) Maurizio Rossini et al.   CALCIFIED TISSUE INTERNATIONAL

What lessons can be learned from γδ T cell-based cancer immunotherapy trials?

(2012) Jean-Jacques Fournié et al.   Cellular & Molecular Immunology

Interleukin-21 Has Activity in Patients With Metastatic Melanoma: A Phase II Study

(2012) Teresa M. Petrella et al.   JOURNAL OF CLINICAL ONCOLOGY

The functional impairment of HCC-infiltrating γδ T cells, partially mediated by regulatory T cells in a TGFβ- and IL-10-dependent manner

(2012) Yong Yi et al.   JOURNAL OF HEPATOLOGY

Tumor-Infiltrating    T Lymphocytes Predict Clinical Outcome in Human Breast Cancer

(2012) C. Ma et al.   JOURNAL OF IMMUNOLOGY

Tumor-promoting Versus Tumor-antagonizing Roles of γδ T Cells in Cancer Immunotherapy

(2012) Volker Kunzmann et al.   JOURNAL OF IMMUNOTHERAPY

The natural and the inducible: interleukin (IL)-17-producing γδ T cells

(2012) Yueh-hsiu Chien et al.   TRENDS IN IMMUNOLOGY

Analysis of Vδ1 T cells in clinical grade melanoma-infiltrating lymphocytes

(2012) Marco Donia et al.   OncoImmunology

Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours

(2011) A J Nicol et al.   BRITISH JOURNAL OF CANCER

Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma

(2011) Hirohito Kobayashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma

(2011) Joshua M. Lang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

(2011) S. R. Mattarollo et al.   CANCER RESEARCH

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

(2011) Yuting Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microenvironment-Derived IL-1 and IL-17 Interact in the Control of Lung Metastasis

(2011) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

Regulatory Role of Vγ1 γδ T Cells in Tumor Immunity through IL-4 Production

(2011) Jianlei Hao et al.   JOURNAL OF IMMUNOLOGY

The Accumulation and Prognosis Value of Tumor Infiltrating IL-17 Producing Cells in Esophageal Squamous Cell Carcinoma

(2011) Lin Lv et al.   PLoS One

Cytokines in Cancer Immunotherapy

(2011) Sylvia Lee et al.   Cancers

Phase I study of bromohydrin pyrophosphate (BrHPP, IPH 1101), a Vγ9Vδ2 T lymphocyte agonist in patients with solid tumors

(2010) Jaafar Bennouna et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

In vivo manipulation of Vγ9Vδ2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients

(2010) S. Meraviglia et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells☆☆☆

(2010) Jun Nakajima et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

IL-17 production by γδ T cells is important for the antitumor effect of Mycobacterium bovis bacillus Calmette-Guérin treatment against bladder cancer

(2010) Ario Takeuchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Expression and function of PD-1 in human γδ T cells that recognize phosphoantigens

(2010) Masashi Iwasaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Naturally Activated V 4    T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin

(2010) W. He et al.   JOURNAL OF IMMUNOLOGY

NKG2A inhibits NKG2C effector functions of γδ T cells: implications in health and disease

(2010) Daniela F. Angelini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis

(2010) Mary Eapen et al.   LANCET ONCOLOGY

Adoptively transferred ex vivo expanded γδ-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer

(2009) Benjamin H. Beck et al.   BREAST CANCER RESEARCH AND TREATMENT

A regulatory cross-talk between Vγ9Vδ2 T lymphocytes and mesenchymal stem cells

(2009) Ludovic Martinet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neonates harbour highly active γδ T cells with selective impairments in preterm infants

(2009) Deena L. Gibbons et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Defective γδ T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients

(2009) Ameera Gaafar et al.   EXPERIMENTAL HEMATOLOGY

Clinical and immunological evaluation of zoledronate-activated Vγ9γδ T-cell-based immunotherapy for patients with multiple myeloma

(2009) Yu Abe et al.   EXPERIMENTAL HEMATOLOGY

IL-21-Mediated Potentiation of Antitumor Cytolytic and Proinflammatory Responses of Human V 9V 2 T Cells for Adoptive Immunotherapy

(2009) A. Thedrez et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TGF- 1 and IL-15 Induce FOXP3+    Regulatory T Cells in the Presence of Antigen Stimulation

(2009) R. Casetti et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor Expression and Function in Subsets of Human γδ T Lymphocytes

(2009) K. Pietschmann et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Intravesical administration of γδ T cells successfully prevents the growth of bladder cancer in the murine model

(2008) Takeshi Yuasa et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phase-I study of Innacell γδ™, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma

(2008) Jaafar Bennouna et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY