Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells

Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation

(2018) Anna Capsomidis et al.   MOLECULAR THERAPY

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma

(2018) Concetta Quintarelli et al.   OncoImmunology

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells

(2018) Camille Khairallah et al.   Frontiers in Immunology

Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines

(2017) Jason Lohmueller et al.   PHARMACOLOGY & THERAPEUTICS

Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies

(2017) Maksim Mamonkin et al.   Cancer Immunology Research

Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model

(2017) Paola Bocca et al.   OncoImmunology

Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor

(2017) A. Bertaina et al.   OncoImmunology

HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma

(2017) Nabil Ahmed et al.   JAMA Oncology

Toxicities of chimeric antigen receptor T cells: recognition and management

(2016) Jennifer N. Brudno et al.   BLOOD

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

(2016) A. R. Almeida et al.   CLINICAL CANCER RESEARCH

An overview of infectious complications after allogeneic hematopoietic stem cell transplantation

(2016) Ugur Sahin et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

In vivo expansion and activation of γδ T cells as immunotherapy for refractory neuroblastoma

(2016) Joseph G. Pressey et al.   MEDICINE

Overcoming Challenges in CAR T-cell Product CGMP Release

(2016) Concetta Quintarelli et al.   MOLECULAR THERAPY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Elucidation of Signaling Pathways from Large-Scale Phosphoproteomic Data Using Protein Interaction Networks

(2016) Jan Daniel Rudolph et al.   Cell Systems

   T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-  +/CD19+ lymphocytes

(2015) I. Airoldi et al.   BLOOD

K562-Derived Whole-Cell Vaccine Enhances Antitumor Responses of CAR-Redirected Virus-Specific Cytotoxic T Lymphocytes In Vivo

(2015) I. Caruana et al.   CLINICAL CANCER RESEARCH

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

(2015) Ignazio Caruana et al.   NATURE MEDICINE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor-Modified T Cells in Solid Tumors

(2014) N. Nishio et al.   CANCER RESEARCH

Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies

(2014) D. C. Deniger et al.   CLINICAL CANCER RESEARCH

Neuroblastoma Killing Properties of V 2 and V 2-Negative   T Cells Following Expansion by Artificial Antigen-Presenting Cells

(2014) J. P. H. Fisher et al.   CLINICAL CANCER RESEARCH

γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

(2014) Pin Wu et al.   IMMUNITY

Cytotoxic and Regulatory Properties of Circulating Vδ1+ γδ T Cells: A New Player on the Cell Therapy Field?

(2014) Gabrielle M Siegers et al.   MOLECULAR THERAPY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

From Monoclonal Antibodies to Chimeric Antigen Receptors for the Treatment of Human Malignancies

(2014) Ignazio Caruana et al.   SEMINARS IN ONCOLOGY

Expanded Human Blood-Derived γδT Cells Display Potent Antigen-Presentation Functions

(2014) Mohd Wajid A. Khan et al.   Frontiers in Immunology

Human Peripheral CD4+ Vδ1+ γδT Cells Can Develop into αβT Cells

(2014) Hendrik Ziegler et al.   Frontiers in Immunology

Generation of Tumor Antigen-Specific T Cell Lines from Pediatric Patients with Acute Lymphoblastic Leukemia--Implications for Immunotherapy

(2013) G. Weber et al.   CLINICAL CANCER RESEARCH

T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo

(2013) C. Geldres et al.   CLINICAL CANCER RESEARCH

Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant

(2013) G Weber et al.   LEUKEMIA

CMV-Independent Lysis of Glioblastoma by Ex Vivo Expanded/Activated Vδ1+ γδ T Cells

(2013) Andrea Knight et al.   PLoS One

What lessons can be learned from γδ T cell-based cancer immunotherapy trials?

(2012) Jean-Jacques Fournié et al.   Cellular & Molecular Immunology

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Characterization of Human γδ T Lymphocytes Infiltrating Primary Malignant Melanomas

(2012) Adriana Cordova et al.   PLoS One

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

(2011) C. U. Louis et al.   BLOOD

Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma

(2011) Joshua M. Lang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells

(2011) Gabrielle M. Siegers et al.   CYTOTHERAPY

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adoptive immunotherapy of lung cancer with immobilized anti-TCRγδ antibody-expanded human γδ T Cells in peripheral blood

(2010) Ning Kang et al.   CANCER BIOLOGY & THERAPY

Aminobisphosphonate-pretreated dendritic cells trigger successful Vγ9Vδ2 T cell amplification for immunotherapy in advanced cancer patients

(2010) Florian Cabillic et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

K562/GM-CSF Immunotherapy Reduces Tumor Burden in Chronic Myeloid Leukemia Patients with Residual Disease on Imatinib Mesylate

(2010) B. D. Smith et al.   CLINICAL CANCER RESEARCH

Rapid αβ TCR-mediated responses in γδ T cells transduced with cancer-specific TCR genes

(2009) A Hiasa et al.   GENE THERAPY

Protumor vs Antitumor Functions of IL-17

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

WT1 peptide-specific T cells generated from peripheral blood of healthy donors: possible implications for adoptive immunotherapy after allogeneic stem cell transplantation

(2009) G Weber et al.   LEUKEMIA

Zoledronate facilitates large-scale ex vivo expansion of functional γδ T cells from cancer patients for use in adoptive immunotherapy*

(2008) M. Kondo et al.   CYTOTHERAPY