Regulatory and effector functions of gamma-delta (γδ) T cells and their therapeutic potential in adoptive cellular therapy for cancer

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy

(2015) Heleen H Van Acker et al.   OncoImmunology

IL-17A Produced by    T Cells Promotes Tumor Growth in Hepatocellular Carcinoma

(2014) S. Ma et al.   CANCER RESEARCH

Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies

(2014) D. C. Deniger et al.   CLINICAL CANCER RESEARCH

γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

(2014) Pin Wu et al.   IMMUNITY

γδ T Cells and Their Potential for Immunotherapy

(2014) Yan-Ling Wu et al.   International Journal of Biological Sciences

Activation of    T Cells by Borrelia burgdorferi Is Indirect via a TLR- and Caspase-Dependent Pathway

(2014) C. Collins et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

Involvement of Notch in Activation and Effector Functions of    T cells

(2014) D. Gogoi et al.   JOURNAL OF IMMUNOLOGY

Role of gamma-delta (γδ ) T cells in autoimmunity

(2014) Sourav Paul et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Murine CD27(-) V 6(+)    T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

(2014) M. Rei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells

(2013) Christian Peters et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Inhibitory Receptor BTLA Controls γδ T Cell Homeostasis and Inflammatory Responses

(2013) Vasileios Bekiaris et al.   IMMUNITY

Regulatory functions of γδ T cells

(2013) Dieter Kabelitz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Human Vγ2Vδ2 T cells limit breast cancer growth by modulating cell survival-, apoptosis-related molecules and microenvironment in tumors

(2013) Reeva Aggarwal et al.   INTERNATIONAL JOURNAL OF CANCER

Phenotypic and Functional Plasticity of Gamma–Delta (γδ) T Cells in Inflammation and Tolerance

(2013) Sourav Paul et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

CD39: A new surface marker of mouse regulatory γδ T cells

(2013) Atsushi Otsuka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic    T Lymphocytes to Tumor Beds

(2013) T. Lanca et al.   JOURNAL OF IMMUNOLOGY

Tumor-Derived    Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence

(2013) J. Ye et al.   JOURNAL OF IMMUNOLOGY

Engineered Drug Resistant γδ T Cells Kill Glioblastoma Cell Lines during a Chemotherapy Challenge: A Strategy for Combining Chemo- and Immunotherapy

(2013) Lawrence S. Lamb et al.   PLoS One

 9 and  2CDR3 domains regulate functional avidity of T cells harboring  9 2TCRs

(2012) C. Grunder et al.   BLOOD

Tumor-killing   -TCRs take center stage

(2012) B. Moser   BLOOD

Anti-tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside

(2012) Mounia S. Braza et al.   BRITISH JOURNAL OF HAEMATOLOGY

Diversity of γδ T-cell antigens

(2012) Willi K Born et al.   Cellular & Molecular Immunology

The functional impairment of HCC-infiltrating γδ T cells, partially mediated by regulatory T cells in a TGFβ- and IL-10-dependent manner

(2012) Yong Yi et al.   JOURNAL OF HEPATOLOGY

Tumor-Infiltrating    T Lymphocytes Predict Clinical Outcome in Human Breast Cancer

(2012) C. Ma et al.   JOURNAL OF IMMUNOLOGY

Tumor-promoting Versus Tumor-antagonizing Roles of γδ T Cells in Cancer Immunotherapy

(2012) Volker Kunzmann et al.   JOURNAL OF IMMUNOTHERAPY

Characterization of Human γδ T Lymphocytes Infiltrating Primary Malignant Melanomas

(2012) Adriana Cordova et al.   PLoS One

Downregulation of CD94/NKG2A Inhibitory Receptor on Decreased γδ T Cells in Patients with Systemic Lupus Erythematosus

(2012) L. Wang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Harnessing γδ T cells in anticancer immunotherapy

(2012) Dalil Hannani et al.   TRENDS IN IMMUNOLOGY

Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours

(2011) A J Nicol et al.   BRITISH JOURNAL OF CANCER

Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma

(2011) Hirohito Kobayashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma

(2011) Joshua M. Lang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

(2011) S. R. Mattarollo et al.   CANCER RESEARCH

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

(2011) Yuting Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microenvironment-Derived IL-1 and IL-17 Interact in the Control of Lung Metastasis

(2011) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

Regulatory Role of Vγ1 γδ T Cells in Tumor Immunity through IL-4 Production

(2011) Jianlei Hao et al.   JOURNAL OF IMMUNOLOGY

Generation of Human Regulatory    T Cells by TCR   Stimulation in the Presence of TGF-  and Their Involvement in the Pathogenesis of Systemic Lupus Erythematosus

(2011) X. Li et al.   JOURNAL OF IMMUNOLOGY

Adoptive Immunotherapy for Advanced Non-small CellLung Cancer Using Zoledronate-expanded γδTCells

(2011) Miki Sakamoto et al.   JOURNAL OF IMMUNOTHERAPY

Human    T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement

(2010) A. Maniar et al.   BLOOD

The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to    T-cell cytotoxicity

(2010) T. Lanca et al.   BLOOD

Phase I study of bromohydrin pyrophosphate (BrHPP, IPH 1101), a Vγ9Vδ2 T lymphocyte agonist in patients with solid tumors

(2010) Jaafar Bennouna et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting    T Lymphocytes for Cancer Immunotherapy: From Novel Mechanistic Insight to Clinical Application

(2010) A. Q. Gomes et al.   CANCER RESEARCH

A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells☆☆☆

(2010) Jun Nakajima et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

IL-17 production by γδ T cells is important for the antitumor effect of Mycobacterium bovis bacillus Calmette-Guérin treatment against bladder cancer

(2010) Ario Takeuchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-infiltrating IL-17-producing γδ T cells support the progression of tumor by promoting angiogenesis

(2010) Daiko Wakita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Naturally Activated V 4    T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin

(2010) W. He et al.   JOURNAL OF IMMUNOLOGY

NKG2D Costimulates Human V 9V 2 T Cell Antitumor Cytotoxicity through Protein Kinase C -Dependent Modulation of Early TCR-Induced Calcium and Transduction Signals

(2010) S. Nedellec et al.   JOURNAL OF IMMUNOLOGY

V 2V 2 T Cell Receptor Recognition of Prenyl Pyrophosphates Is Dependent on All CDRs

(2010) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Zoledronate Stimulates γδ T Cells in Prostate Cancer Patients

(2010) Michio Naoe et al.   ONCOLOGY RESEARCH

The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial    T Cell Activation

(2010) D. A. Witherden et al.   SCIENCE

Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies

(2009) J. Gertner-Dardenne et al.   BLOOD

Epigenetic mechanisms of regulation of Foxp3 expression

(2009) G. Lal et al.   BLOOD

The NKG2D ligand ULBP4 binds to TCR 9/ 2 and induces cytotoxicity to tumor cells through both TCR   and NKG2D

(2009) Y. Kong et al.   BLOOD

DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vγ9Vδ2 T cells

(2009) Olivier Toutirais et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Defective γδ T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients

(2009) Ameera Gaafar et al.   EXPERIMENTAL HEMATOLOGY

Clinical and immunological evaluation of zoledronate-activated Vγ9γδ T-cell-based immunotherapy for patients with multiple myeloma

(2009) Yu Abe et al.   EXPERIMENTAL HEMATOLOGY

Rapid αβ TCR-mediated responses in γδ T cells transduced with cancer-specific TCR genes

(2009) A Hiasa et al.   GENE THERAPY

Human peripheral γδ T cells possess regulatory potential

(2009) Anja A. Kühl et al.   IMMUNOLOGY

Identification and characterization of Foxp3+ γδ T cells in mouse and human

(2009) Ning Kang et al.   IMMUNOLOGY LETTERS

Cutting Edge: TGF- 1 and IL-15 Induce FOXP3+    Regulatory T Cells in the Presence of Antigen Stimulation

(2009) R. Casetti et al.   JOURNAL OF IMMUNOLOGY

Protumor vs Antitumor Functions of IL-17

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets

(2009) Julie C Ribot et al.   NATURE IMMUNOLOGY

Natural killer and γδ T cells in haematological malignancies: enhancing the immune effectors

(2009) Jérôme Rey et al.   TRENDS IN MOLECULAR MEDICINE

Isopentenyl Pyrophosphate-Activated CD56+    T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma

(2008) A. A.Z. Alexander et al.   CLINICAL CANCER RESEARCH

Vγ9Vδ2 T cell cytotoxicity against tumor cells is enhanced by monoclonal antibody drugs—Rituximab and trastuzumab

(2008) Hirotake Tokuyama et al.   INTERNATIONAL JOURNAL OF CANCER