Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation

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Discovery of a periosteal stem cell mediating intramembranous bone formation

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Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy

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Osteogenic Sarcoma: A 21st Century Review

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WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma

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mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo

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Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice

(2016) Qinggang Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOTCH signaling in skeletal progenitors is critical for fracture repair

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LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

(2016) Filippos Kottakis et al.   NATURE

Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies

(2016) Ander Abarrategi et al.   Stem Cells International

Targeting LKB1 in cancer – exposing and exploiting vulnerabilities

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Identification and Specification of the Mouse Skeletal Stem Cell

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Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial

(2015) Giovanni Grignani et al.   LANCET ONCOLOGY

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

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Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?

(2014) Anthony J. Mutsaers et al.   BONE

Notch Activation as a Driver of Osteogenic Sarcoma

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Novel mutations and role of the LKB1 gene as a tumor suppressor in renal cell carcinoma

(2014) Zübeyde Yalniz et al.   TUMOR BIOLOGY

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA

(2013) Anthony J. Mutsaers et al.   BONE

The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 Upregulation in Osteosarcoma Preclinical Models

(2013) Y. Pignochino et al.   CLINICAL CANCER RESEARCH

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation

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Nouvelle classification de l’OMS des tumeurs des tissus mous et des os

(2012) Jean-Michel Coindre   ANNALES DE PATHOLOGIE

LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma

(2012) Wenjin Liu et al.   CANCER CELL

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

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(2011) Florent Elefteriou et al.   BONE

Phase II Study of the Mammalian Target of Rapamycin Inhibitor Ridaforolimus in Patients With Advanced Bone and Soft Tissue Sarcomas

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Rb regulates fate choice and lineage commitment in vivo

(2010) Eliezer Calo et al.   NATURE

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice

(2009) P. P. Lin et al.   CARCINOGENESIS

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

(2009) Maya Kansara et al.   JOURNAL OF CLINICAL INVESTIGATION

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Osteogenic tumours in Lkb1-deficient mice

(2008) James Robinson et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

(2008) C. R. Walkley et al.   GENES & DEVELOPMENT

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

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