Synthesis of Novel Glycolipid Mimetics of Heparan Sulfate and Their Application in Colorectal Cancer Treatment in a Mouse Model

Heparin – an old drug with multiple potential targets in Covid‐19 therapy

(2020) Ulf Lindahl et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Heparanase and the hallmarks of cancer

(2020) Krishnath M. Jayatilleke et al.   Journal of Translational Medicine

Improved recovery from limb ischaemia by delivery of an affinity-isolated heparan sulphate

(2018) Selina Poon et al.   ANGIOGENESIS

Novel Benzazole Derivatives Endowed with Potent anti-Heparanase Activity

(2018) Valentina Noemi Madia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression

(2018) Israel Vlodavsky et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy

(2018) Olga V. Zubkova et al.   ACS Chemical Biology

Low sulfated heparins target multiple proteins for central nervous system repair

(2018) George A. McCanney et al.   GLIA

The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard

(2018) Mohit Chhabra et al.   MOLECULES

Heparanase: From basic research to therapeutic applications in cancer and inflammation

(2016) Israel Vlodavsky et al.   DRUG RESISTANCE UPDATES

Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases

(2016) Silvia Rivara et al.   Future Medicinal Chemistry

Heparin centenary – an ever-young life-saving drug

(2016) Giangiacomo Torri et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Heparanase is required for activation and function of macrophages

(2016) Lilach Gutter-Kapon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications

(2015) Peter C. Tyler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Function from within: Autophagy induction by HPSE/heparanase—new possibilities for intervention

(2015) Neta Ilan et al.   Autophagy

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis

(2015) Xinyang Hu et al.   STEM CELLS

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease

(2013) Ralf Schwörer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis

(2012) Vito Ferro et al.   JOURNAL OF MEDICINAL CHEMISTRY

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

A Systems Biology Approach for the Investigation of the Heparin/Heparan Sulfate Interactome

(2011) Alessandro Ori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

(2011) He Zhou et al.   PLoS One

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening

(2009) Edward Hammond et al.   ANALYTICAL BIOCHEMISTRY

The molecular basis and functional implications of chemokine interactions with heparan sulphate

(2009) Hugues Lortat-Jacob   CURRENT OPINION IN STRUCTURAL BIOLOGY

Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage

(2009) Chun-Jen Liu et al.   JOURNAL OF HEPATOLOGY