Maternal immune protection against infectious diseases

Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection

(2022) Lydia L. Shook et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications

(2022) Torri D. Metz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial

(2022) Carolyn M. Boudreau et al.   Cell Reports

Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19–Associated Hospitalization in Infants Aged

(2022) Natasha B. Halasa et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Infant immunity against viral infections is advanced by the placenta-dependent vertical transfer of maternal antibodies

(2021) Marie Albrecht et al.   VACCINE

In utero human cytomegalovirus infection is associated with increased levels of putatively protective maternal antibodies in nonprimary infection: evidence for boosting but not protection

(2021) Jeffrey R Dorfman et al.   CLINICAL INFECTIOUS DISEASES

Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study

(2021) Kathryn J. Gray et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Mutations that confer resistance to broadly-neutralizing antibodies define HIV-1 variants of transmitting mothers from that of non-transmitting mothers

(2021) Amit Kumar et al.   PLoS Pathogens

Congenital human cytomegalovirus infection is associated with decreased transplacental IgG transfer efficiency due to maternal hypergammaglobulinemia

(2021) Eleanor C Semmes et al.   CLINICAL INFECTIOUS DISEASES

Association Between BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women

(2021) Inbal Goldshtein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy

(2021) Noa Dagan et al.   NATURE MEDICINE

Infections at the maternal–fetal interface: an overview of pathogenesis and defence

(2021) Christina J. Megli et al.   NATURE REVIEWS MICROBIOLOGY

A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection

(2021) Brenna L. Hughes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vertically transferred maternal immune cells promote neonatal immunity against early life infections

(2021) Ina Annelies Stelzer et al.   Nature Communications

Innate immune defenses at the maternal-fetal interface

(2021) Eleanor C Semmes et al.   CURRENT OPINION IN IMMUNOLOGY

Monoclonal Antibodies Casirivimab and Imdevimab in Pregnancy for Coronavirus Disease 2019 (COVID-19)

(2021) Christopher Mayer et al.   OBSTETRICS AND GYNECOLOGY

Highly active engineered IgG3 antibodies against SARS-CoV-2

(2021) Somanath Kallolimath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The half-life of maternal transplacental antibodies against diphtheria, tetanus, and pertussis in infants: an individual participant data meta-analysis

(2021) Blanché Oguti et al.   VACCINE

Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review

(2020) Sabine Vygen-Bonnet et al.   BMC INFECTIOUS DISEASES

Efficacy, immunogenicity, and safety of an oral influenza vaccine: a placebo-controlled and active-controlled phase 2 human challenge study

(2020) David Liebowitz et al.   LANCET INFECTIOUS DISEASES

The effectiveness of influenza vaccination in pregnancy in relation to child health outcomes: Systematic review and meta-analysis

(2020) J.R. Jarvis et al.   VACCINE

Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a nonhuman primate model

(2020) Matteo Stoppato et al.   VACCINE

An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

(2020) Deepshika Ramanan et al.   CELL

A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques

(2020) Koen K. A. Van Rompay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies

(2020) Sara Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

(2020) David R. Martinez et al.   mBio

Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies

(2020) Angelene F. Richards et al.   PLoS Neglected Tropical Diseases

Induction of Neutralizing Responses against Autologous Virus in Maternal HIV Vaccine Trials

(2020) Eliza D. Hompe et al.   mSphere

Short- and long-term impact of vaccination against cytomegalovirus: a modeling study

(2020) Ganna Rozhnova et al.   BMC Medicine

Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants

(2020) Shabir A. Madhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants

(2020) M. Pamela Griffin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection

(2020) Lisa Perruzza et al.   Frontiers in Immunology

Changes in Human Milk Immunoglobulin Profile During Prolonged Lactation

(2020) Matylda Czosnykowska-Łukacka et al.   Frontiers in Pediatrics

Update on Transplacental Transfer of IgG Subclasses: Impact of Maternal and Fetal Factors

(2020) Toby Clements et al.   Frontiers in Immunology

Maternal antibody interference contributes to reduced rotavirus vaccine efficacy in developing countries

(2020) Claire E. Otero et al.   PLoS Pathogens

The repertoire of maternal anti-viral antibodies in human newborns

(2019) Christian Pou et al.   NATURE MEDICINE

Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk

(2019) Gustavo Caballero-Flores et al.   Cell Host & Microbe

Epidemiology and burden of influenza in healthy children aged 6 to 35 months: analysis of data from the placebo arm of a phase III efficacy trial

(2019) Clotilde El Guerche-Séblain et al.   BMC INFECTIOUS DISEASES

Survey of cellular immune responses to human cytomegalovirus infection in the microenvironment of the uterine–placental interface

(2019) Takako Tabata et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

(2019) Matthew G. Darby et al.   Science Advances

Fc Glycan-Mediated Regulation of Placental Antibody Transfer

(2019) Madeleine F. Jennewein et al.   CELL

Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women

(2019) David R. Martinez et al.   CELL

Optimal timing of influenza vaccine during pregnancy: A systematic review and meta‐analysis

(2019) Will Cuningham et al.   Influenza and Other Respiratory Viruses

Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants

(2019) Kathyayini P. Gopalakrishna et al.   NATURE MEDICINE

Risk of Zika microcephaly correlates with features of maternal antibodies

(2019) Davide F. Robbiani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers

(2019) Maria Vono et al.   Cell Reports

DNA vaccination before conception protects Zika virus–exposed pregnant macaques against prolonged viremia and improves fetal outcomes

(2019) Koen K. A. Van Rompay et al.   Science Translational Medicine

Maternal vaccination and protective immunity against Zika virus vertical transmission

(2019) Chao Shan et al.   Nature Communications

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody

(2019) Simone I. Richardson et al.   PLoS Pathogens

Expression of FcRn receptor in placental tissue and its relationship with IgG levels in term and preterm newborns

(2018) Natalia A. Lozano et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials

(2018) Kayvon Modjarrad et al.   LANCET

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials

(2018) Martin R Gaudinski et al.   LANCET

Prevention of maternal-fetal transmission of CMV by hyperimmunoglobulin (HIG) administered after a primary maternal CMV infectionin early gestation

(2018) Karl Oliver Kagan et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity

(2018) Shinu John et al.   VACCINE

Declining responsiveness to influenza vaccination with progression of human pregnancy

(2018) Elizabeth P. Schlaudecker et al.   VACCINE

Maternally derived antibodies to Schizont Egress Antigen-1 and protection of infants from severe malaria

(2018) Jonathan D Kurtis et al.   CLINICAL INFECTIOUS DISEASES

Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?

(2018) David R. Martinez et al.   PLoS Pathogens

The impact of timing of maternal influenza immunization on infant antibody levels at birth

(2018) Z. Zhong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

(2018) Matthias G. Pauthner et al.   IMMUNITY

HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth

(2018) Jelle van Schooten et al.   Retrovirology

Animal Models of Zika Virus Infection during Pregnancy

(2018) Elizabeth Caine et al.   Viruses-Basel

Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection

(2018) Sasirekha Ramani et al.   Nature Communications

Breast Milk Human Cytomegalovirus (CMV) Viral Load and the Establishment of Breast Milk CMV-pp65-Specific CD8 T Cells in Human CMV Infected Mothers

(2017) David C Moylan et al.   JOURNAL OF INFECTIOUS DISEASES

Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood

(2017) Whitney E Harrington et al.   JOURNAL OF INFECTIOUS DISEASES

Breast Milk Transforming Growth Factor β Is Associated With Neonatal Gut Microbial Composition

(2017) Alexandra R. Sitarik et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

(2017) Ting Shi et al.   LANCET

Maternal Immunization

(2017) Saad B. Omer   NEW ENGLAND JOURNAL OF MEDICINE

Maternal but Not Infant Anti-HIV-1 Neutralizing Antibody Response Associates with Enhanced Transmission and Infant Morbidity

(2017) Melissa Ghulam-Smith et al.   mBio

Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin

(2017) Celia Dechavanne et al.   PLOS MEDICINE

SIgA, TGF-β1, IL-10, and TNFα in Colostrum Are Associated with Infant Group B Streptococcus Colonization

(2017) Kirsty Le Doare et al.   Frontiers in Immunology

Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis

(2017) Mohan Pammi et al.   Microbiome

Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplant

(2017) Sami B. Kanaan et al.   OncoImmunology

HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies

(2016) Kwinten Sliepen et al.   Expert Review of Vaccines

Human Norovirus Interactions with Histo-Blood Group Antigens and Human Milk Oligosaccharides

(2016) Horst Schroten et al.   JOURNAL OF VIROLOGY

Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides

(2016) Stefan Weichert et al.   JOURNAL OF VIROLOGY

Maternal immunisation with trivalent inactivated influenza vaccine for prevention of influenza in infants in Mali: a prospective, active-controlled, observer-blind, randomised phase 4 trial

(2016) Milagritos D Tapia et al.   LANCET INFECTIOUS DISEASES

A longitudinal study of human milk composition in the second year postpartum: implications for human milk banking

(2016) Maryanne T. Perrin et al.   Maternal and Child Nutrition

Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization

(2016) G G Fouda et al.   Mucosal Immunology

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

(2016) Rajeev Gautam et al.   NATURE

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

(2016) Gopal Sapparapu et al.   NATURE

Zika Virus and Birth Defects — Reviewing the Evidence for Causality

(2016) Sonja A. Rasmussen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Breastfeeding linked to the reduction of both rotavirus shedding and IgA levels after Rotarix® immunization in Mexican infants

(2016) Aurora Bautista-Marquez et al.   VACCINE

Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities

(2016) Anna J. Battersby et al.   Frontiers in Immunology

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

(2015) Steven W. de Taeye et al.   CELL

Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells

(2015) Jeremy M. Kinder et al.   CELL

Passively Acquired Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity in HIV-Infected Infants Is Associated with Reduced Mortality

(2015) Caitlin Milligan et al.   Cell Host & Microbe

Maternal HIV-1 envelope–specific antibody responses and reduced risk of perinatal transmission

(2015) Sallie R. Permar et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of feeding whole compared with cell-free colostrum on calf immune status: The neonatal period

(2015) S.N. Langel et al.   JOURNAL OF DAIRY SCIENCE

Impact of Placental Malaria and Hypergammaglobulinemia on Transplacental Transfer of Respiratory Syncytial Virus Antibody in Papua New Guinea

(2015) Jessica E. Atwell et al.   JOURNAL OF INFECTIOUS DISEASES

Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity

(2015) Susan Zolla-Pazner et al.   JOURNAL OF VIROLOGY

Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: a phase 3 randomised double-blind placebo-controlled trial

(2015) Katherine L O'Brien et al.   LANCET INFECTIOUS DISEASES

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

(2015) Cornelia Lindner et al.   NATURE IMMUNOLOGY

Safety of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis and Influenza Vaccinations in Pregnancy

(2015) Lakshmi Sukumaran et al.   OBSTETRICS AND GYNECOLOGY

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Effectiveness of seasonal influenza vaccination during pregnancy in preventing influenza infection in infants, England, 2013/14

(2014) G Dabrera et al.   Eurosurveillance

An Indispensable Role for the Chemokine Receptor CCR10 in IgA Antibody-Secreting Cell Accumulation

(2014) O. Morteau et al.   JOURNAL OF IMMUNOLOGY

Restricted isotype, distinct variable gene usage and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women

(2014) C R Sacha et al.   Mucosal Immunology

A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus

(2014) Maria Grazia Revello et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influenza Vaccination of Pregnant Women and Protection of Their Infants

(2014) Shabir A. Madhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hearing Loss and Congenital CMV Infection: A Systematic Review

(2014) J. Goderis et al.   PEDIATRICS

Maternal Antibodies: Clinical Significance, Mechanism of Interference with Immune Responses, and Possible Vaccination Strategies

(2014) Stefan Niewiesk   Frontiers in Immunology

Human milk oligosaccharides inhibit rotavirus infectivity in vitro and in acutely infected piglets

(2013) Shelly N. Hester et al.   BRITISH JOURNAL OF NUTRITION

Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection

(2013) Daisuke Tokuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Cells in Human Milk

(2013) Foteini Hassiotou et al.   JOURNAL OF HUMAN LACTATION

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

(2013) Masashi Shingai et al.   NATURE

IgA and Neutralizing Antibodies to Influenza A Virus in Human Milk: A Randomized Trial of Antenatal Influenza Immunization

(2013) Elizabeth P. Schlaudecker et al.   PLoS One

Maternal and Neonatal Outcomes among Pregnant Women with 2009 Pandemic Influenza A(H1N1) Illness in Florida, 2009-2010: A Population-Based Cohort Study

(2013) Timothy J. Doyle et al.   PLoS One

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

(2013) R. P. Ringe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk

(2013) G. G. Fouda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants

(2013) Genevieve G Fouda et al.   Retrovirology

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Short Communication: HIV Type 1 Subtype C Variants Transmitted Through the Bottleneck of Breastfeeding Are Sensitive to New Generation Broadly Neutralizing Antibodies Directed Against Quaternary and CD4-Binding Site Epitopes

(2012) Elizabeth S. Russell et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Effects of influenza on pregnant women and infants

(2012) Sonja A. Rasmussen et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Massive expansion of maternal T cells in response to EBV infection in a patient with SCID-Xl

(2012) F. Touzot et al.   BLOOD

Breast Milk Parasite-Specific Antibodies and Protection From Amebiasis and Cryptosporidiosis in Bangladeshi Infants: A Prospective Cohort Study

(2012) Poonum S. Korpe et al.   CLINICAL INFECTIOUS DISEASES

HIV-Specific Antibodies Capable of ADCC Are Common in Breastmilk and Are Associated with Reduced Risk of Transmission in Women with High Viral Loads

(2012) Jennifer Mabuka et al.   PLoS Pathogens

Influenza Hemagglutination-Inhibition Antibody Titer as a Correlate of Vaccine-Induced Protection

(2011) Suzanne E. Ohmit et al.   JOURNAL OF INFECTIOUS DISEASES

The Genetic Bottleneck in Vertical Transmission of Subtype C HIV-1 Is Not Driven by Selection of Especially Neutralization-Resistant Virus from the Maternal Viral Population

(2011) E. S. Russell et al.   JOURNAL OF VIROLOGY

Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity

(2011) F-E Johansen et al.   Mucosal Immunology

Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers

(2011) K. A. Swanson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytomegalovirus Neutralization by Hyperimmune and Standard Intravenous Immunoglobulin Preparations

(2011) Christina B. Planitzer et al.   TRANSPLANTATION

Balancing acts: the role of TGF-β in the mucosal immune system

(2011) Joanne E. Konkel et al.   TRENDS IN MOLECULAR MEDICINE

Perspectives on Immunoglobulins in Colostrum and Milk

(2011) Walter L. Hurley et al.   Nutrients

Cytokines in Human Milk

(2010) Roberto Garofalo   JOURNAL OF PEDIATRICS

Mother-to-child transmission of HIV-1 in sub-Saharan Africa: Past, present and future challenges

(2010) Taha E. Taha   LIFE SCIENCES

Restricted Genetic Diversity of HIV-1 Subtype C Envelope Glycoprotein from Perinatally Infected Zambian Infants

(2010) Hong Zhang et al.   PLoS One

Human Milk-Derived B Cells: A Highly Activated Switched Memory Cell Population Primed to Secrete Antibodies

(2009) E. Tuaillon et al.   JOURNAL OF IMMUNOLOGY

Vaccine Prevention of Maternal Cytomegalovirus Infection

(2009) Robert F. Pass et al.   NEW ENGLAND JOURNAL OF MEDICINE

Maternal microchimerism in human fetal tissues

(2008) Anna Maria Jonsson et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheeze

(2008) Lone Graff Stensballe et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

(2008) J. E. Mold et al.   SCIENCE