Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells

CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway

(2012) Hervé Sartelet et al.   HISTOPATHOLOGY

Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells

(2010) Y. K. Wang et al.   CARCINOGENESIS

Lipid rafts play an important role for maintenance of embryonic stem cell self-renewal

(2010) Min Young Lee et al.   JOURNAL OF LIPID RESEARCH

The Stem Cell Marker CD133 (Prominin-1) is Phosphorylated on Cytoplasmic Tyrosine-828 and Tyrosine-852 by Src and Fyn Tyrosine Kinases

(2009) Dominique Boivin et al.   BIOCHEMISTRY

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

(2009) Bijay S. Jaiswal et al.   CANCER CELL

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

(2009) K. V. Lu et al.   CANCER RESEARCH

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

(2009) H. T. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells

(2008) Scott Bidlingmaier et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CD133 identifies perivascular niches in grade II–IV astrocytomas

(2008) Karina Christensen et al.   JOURNAL OF NEURO-ONCOLOGY

Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas

(2008) Kyeung Min Joo et al.   LABORATORY INVESTIGATION

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

(2008) Jinyan Du et al.   NATURE BIOTECHNOLOGY

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Glioma Formation, Cancer Stem Cells, and Akt Signaling

(2008) Dolores Hambardzumyan et al.   Stem Cell Reviews and Reports

Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition

(2008) Christine E. Eyler et al.   STEM CELLS

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

(2007) Jian Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells

(2007) P. B Dirks   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES