Modular design of synthetic receptors for programmed gene regulation in cell therapies

Genetic engineering of T cells for immunotherapy

(2021) Gavin I. Ellis et al.   NATURE REVIEWS GENETICS

T cell circuits that sense antigen density with an ultrasensitive threshold

(2021) Rogelio A. Hernandez-Lopez et al.   SCIENCE

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

(2021) Evan W. Weber et al.   SCIENCE

SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models

(2021) Axel Hyrenius-Wittsten et al.   Science Translational Medicine

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

(2021) Joseph H. Choe et al.   Science Translational Medicine

Precise T cell recognition programs designed by transcriptionally linking multiple receptors

(2020) Jasper Z. Williams et al.   SCIENCE

Engineering and Design of Chimeric Antigen Receptors

(2019) Sonia Guedan et al.   Molecular Therapy-Methods & Clinical Development

Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting

(2019) Shivani Srivastava et al.   CANCER CELL

A toolkit for studying cell surface shedding of diverse transmembrane receptors

(2019) Amanda N Hayward et al.   eLife

Programming self-organizing multicellular structures with synthetic cell-cell signaling

(2018) Satoshi Toda et al.   SCIENCE

Determination of Lentiviral Infectious Titer by a Novel Droplet Digital PCR Method

(2018) Yu Wang et al.   Human Gene Therapy Methods

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Tumor Antigen Escape from CAR T-cell Therapy

(2018) Robbie G. Majzner et al.   Cancer Discovery

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Customizing Functionality and Payload Delivery for Receptor-Engineered T Cells

(2016) Christopher A. Klebanoff et al.   CELL

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

(2016) Kole T. Roybal et al.   CELL

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interleukin 12: still a promising candidate for tumor immunotherapy?

(2014) Witold Lasek et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A robust pipeline for rapid production of versatile nanobody repertoires

(2014) Peter C Fridy et al.   NATURE METHODS

Modular Extracellular Sensor Architecture for Engineering Mammalian Cell-based Devices

(2014) Nichole M. Daringer et al.   ACS Synthetic Biology

Ubiquitinations in the Notch Signaling Pathway

(2013) Julien Moretti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endocytosis and control of Notch signaling

(2012) Vasundhara Kandachar et al.   CURRENT OPINION IN CELL BIOLOGY

Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma

(2012) Richard A. Morgan et al.   HUMAN GENE THERAPY

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline

(2010) H. A. Coleman et al.   DEVELOPMENT

Human ROBO1 is cleaved by metalloproteinases and γ-secretase and migrates to the nucleus in cancer cells

(2010) Motoaki Seki et al.   FEBS LETTERS

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES