Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair

Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy

(2020) Jordon M. Inkol et al.   Veterinary and Comparative Oncology

Identification and validation of a prognostic 8-gene signature for acute myeloid leukemia

(2020) Yanli Zhang et al.   LEUKEMIA & LYMPHOMA

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

(2020) Tiffany Tsang et al.   NATURE CELL BIOLOGY

Inhibition of Copper Transport Induces Apoptosis in Triple Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis

(2019) Olga Karginova et al.   MOLECULAR CANCER THERAPEUTICS

Blockage of SLC31A1-dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death

(2019) Ze Yu et al.   CELL PROLIFERATION

Copper Chaperone for Superoxide Dismutase Promotes Breast Cancer Cell Proliferation and Migration via ROS-Mediated MAPK/ERK Signaling

(2019) Yanping Li et al.   Frontiers in Pharmacology

Novel Interaction of Antioxidant-1 with TRAF4: Role in Inflammatory Responses in Endothelial Cells

(2019) Archita Das et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

LRH1 enhances cell resistance to chemotherapy by transcriptionally activating MDC1 expression and attenuating DNA damage in human breast cancer

(2018) S. Wang et al.   ONCOGENE

Defining the human copper proteome and analysis of its expression variation in cancers

(2017) S. Blockhuys et al.   Metallomics

ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks

(2017) Kyung Yong Lee et al.   MOLECULAR CELL

Tat-ATOX1 inhibits streptozotocin-induced cell death in pancreatic RINm5F cells and attenuates diabetes in a mouse model

(2016) EUN HEE AHN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells

(2016) Quan Zeng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy

(2015) Michael Goldstein et al.   Annual Review of Medicine

Targeting copper in cancer therapy: ‘Copper That Cancer’

(2015) Delphine Denoyer et al.   Metallomics

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

(2015) Jing Wang et al.   Nature Chemistry

Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition

(2015) Z Wang et al.   Cell Death & Disease

Copper Signaling Axis as a Target for Prostate Cancer Therapeutics

(2014) R. Safi et al.   CANCER RESEARCH

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

(2014) G. MacDonald et al.   Science Signaling

Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells

(2013) HUAWEI CAI et al.   ONCOLOGY REPORTS

Homocysteine Restricts Copper Availability Leading to Suppression of Cytochrome C Oxidase Activity in Phenylephrine-Treated Cardiomyocytes

(2013) Xiao Zuo et al.   PLoS One

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

(2013) S. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C

(2012) Kyu Kwang Kim et al.   BMC CANCER

Pre-operative chemoradiation followed by post-operative adjuvant therapy with tetrathiomolybdate, a novel copper chelator, for patients with resectable esophageal cancer

(2012) Bryan J. Schneider et al.   INVESTIGATIONAL NEW DRUGS

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

(2012) M. L. Turski et al.   MOLECULAR AND CELLULAR BIOLOGY

The relationship of copper to DNA damage and damage prevention in humans

(2012) Maria C. Linder   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Overcoming multidrug resistance (MDR) in cancer in vitro and in vivo by a quinoline derivative

(2011) Avishek Ganguly et al.   BIOMEDICINE & PHARMACOTHERAPY

Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila

(2011) Haiqing Hua et al.   BIOMETALS

Redox active copper chelate overcomes multidrug resistance in T-lymphoblastic leukemia cell by triggering apoptosis

(2011) Avishek Ganguly et al.   Molecular BioSystems

Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator

(2010) Seiko Ishida et al.   CANCER CELL

TISSUE COPPER CONTENT IN PRIMARY AND METASTATIC LIVER CANCERS

(2010) Joji Haratake et al.   PATHOLOGY INTERNATIONAL

The role of copper in drug-resistant murine and human tumors

(2008) S. Majumder et al.   BIOMETALS

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell Proliferation

(2008) Shinichi Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of the loss of Atox1 on the cellular pharmacology of cisplatin

(2008) Roohangiz Safaei et al.   JOURNAL OF INORGANIC BIOCHEMISTRY